Severe metabolic acidosis causes early lethality in NBC1 W516X knock-in mice as a model of human isolated proximal renal tubular acidosis

Biochemistry, Genetics and Molecular Biology

• Messenger RNA 100%
• Nonsense-Mediated Decay 100%
• Animal Model 50%
• Protein Catabolism 50%
• Transcription 50%
• Cotransporter 50%
• Mouse Mutant 50%
• Survival Time 50%
• Nonsense Mutation 50%
• Absorption 50%
• Azotemia 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Messenger RNA 100%
• Lethality 100%
• Kidney Tubule Acidosis 100%
• Metabolic Acidosis 100%
• Dicarbonate 50%
• Kidney Failure 25%
• Base 25%
• Anemia 25%
• Eye Disease 25%
• Survival Time 25%
• Growth Retardation 25%
• Mouse Mutant 25%

Medicine and Dentistry

• Metabolic Acidosis 100%
• Lethality 100%
• Messenger RNA 50%
• Sodium Bicarbonate 50%
• Nonsense Mediated mRNA Decay 50%
• Survival Time 25%
• Protein Degradation 25%
• Base 25%
• Renal Failure 25%
• Anemia 25%
• Eye Disease 25%
• Growth Retardation 25%
• Cornea Opacity 25%
• Nonsense Mutation 25%