New-onset demyelination induced by infliximab therapy in two rheumatoid arthritis patients

Makoto Tanno; Ichiro Nakamura; Shunsuke Kobayashi; Kumiko Kurihara; Katsumi Ito

doi:10.1007/s10067-005-0097-x

New-onset demyelination induced by infliximab therapy in two rheumatoid arthritis patients

Makoto Tanno, Ichiro Nakamura, Shunsuke Kobayashi, Kumiko Kurihara, Katsumi Ito

研究成果: ジャーナルへの寄稿 › 記事 › 査読

39 被引用数 (Scopus)

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Therapies aimed at inhibiting tumor necrosis factor, a proinflammatory cytokine implicated in autoimmune disease, are effective for rheumatoid arthritis (RA) and Crohn's disease. We report two patients who newly developed multiple demyelinating lesions in the central nervous system in the course of infliximab therapy for active RA. Neurological symptoms and the number of gadolinium-diethylenetriamine pentaacetic acid-enhanced lesions in magnetic resonance imaging gradually diminished with steroid treatment.

本文言語	英語
ページ（範囲）	929-933
ページ数	5
ジャーナル	Clinical Rheumatology
巻	25
号	6
DOI	https://doi.org/10.1007/s10067-005-0097-x
出版ステータス	出版済み - 11月 2006
外部発表	はい

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title = "New-onset demyelination induced by infliximab therapy in two rheumatoid arthritis patients",

abstract = "Therapies aimed at inhibiting tumor necrosis factor, a proinflammatory cytokine implicated in autoimmune disease, are effective for rheumatoid arthritis (RA) and Crohn's disease. We report two patients who newly developed multiple demyelinating lesions in the central nervous system in the course of infliximab therapy for active RA. Neurological symptoms and the number of gadolinium-diethylenetriamine pentaacetic acid-enhanced lesions in magnetic resonance imaging gradually diminished with steroid treatment.",

keywords = "Demyelinating, Infliximab, Magnetic resonance imaging (MRI), Multiple sclerosis, Rheumatoid arthritis, Tumor necrosis factor",

author = "Makoto Tanno and Ichiro Nakamura and Shunsuke Kobayashi and Kumiko Kurihara and Katsumi Ito",

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AU - Nakamura, Ichiro

AU - Kobayashi, Shunsuke

AU - Kurihara, Kumiko

AU - Ito, Katsumi

PY - 2006/11

Y1 - 2006/11

N2 - Therapies aimed at inhibiting tumor necrosis factor, a proinflammatory cytokine implicated in autoimmune disease, are effective for rheumatoid arthritis (RA) and Crohn's disease. We report two patients who newly developed multiple demyelinating lesions in the central nervous system in the course of infliximab therapy for active RA. Neurological symptoms and the number of gadolinium-diethylenetriamine pentaacetic acid-enhanced lesions in magnetic resonance imaging gradually diminished with steroid treatment.

AB - Therapies aimed at inhibiting tumor necrosis factor, a proinflammatory cytokine implicated in autoimmune disease, are effective for rheumatoid arthritis (RA) and Crohn's disease. We report two patients who newly developed multiple demyelinating lesions in the central nervous system in the course of infliximab therapy for active RA. Neurological symptoms and the number of gadolinium-diethylenetriamine pentaacetic acid-enhanced lesions in magnetic resonance imaging gradually diminished with steroid treatment.

KW - Demyelinating

KW - Infliximab

KW - Magnetic resonance imaging (MRI)

KW - Multiple sclerosis

KW - Rheumatoid arthritis

KW - Tumor necrosis factor

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JO - Clinical Rheumatology

JF - Clinical Rheumatology

IS - 6

ER -

New-onset demyelination induced by infliximab therapy in two rheumatoid arthritis patients

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