Isolation of Inhibitors of Adenylate Cyclase from Dan-shen, the Root of Salvia miltiorrhiza

Hiroshi Kohda; Osamu Takeda; Seiji Tanaka; Kazuo Yamasaki; Atsushi Yamashita; Tomonori Kurokawa; Sadahiko Ishibashi

doi:10.1248/cpb.37.1287

Isolation of Inhibitors of Adenylate Cyclase from Dan-shen, the Root of Salvia miltiorrhiza

Hiroshi Kohda
, Osamu Takeda
, Seiji Tanaka
, Kazuo Yamasaki
, Atsushi Yamashita
, Tomonori Kurokawa
, Sadahiko Ishibashi

Hiroshima University

研究成果: ジャーナルへの寄稿 › 記事 › 査読

72 被引用数 (Scopus)

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The effect of dan-shen extract, the root of Salvia miltiorrhiza, on adenylate cyclase was investigated in both rat brain and rat erythrocytes. The EtOAc fraction of the MeOH extract was proved to have significant inhibitory activity. Potent inhibitory principles in the EtOAc fraction were isolated and identified as 4 polyphenolic acids, rosemarinic acid, lithospermic acid, and their methyl ester derivatives. dan-shen; Salvia miltiorrhiza; adenylate cyclase; rosemarinic acid; lithospermic acid,.

本文言語	英語
ページ（範囲）	1287-1290
ページ数	4
ジャーナル	Chemical and Pharmaceutical Bulletin
巻	37
号	5
DOI	https://doi.org/10.1248/cpb.37.1287
出版ステータス	出版済み - 1989
外部発表	はい

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title = "Isolation of Inhibitors of Adenylate Cyclase from Dan-shen, the Root of Salvia miltiorrhiza",

abstract = "The effect of dan-shen extract, the root of Salvia miltiorrhiza, on adenylate cyclase was investigated in both rat brain and rat erythrocytes. The EtOAc fraction of the MeOH extract was proved to have significant inhibitory activity. Potent inhibitory principles in the EtOAc fraction were isolated and identified as 4 polyphenolic acids, rosemarinic acid, lithospermic acid, and their methyl ester derivatives. dan-shen; Salvia miltiorrhiza; adenylate cyclase; rosemarinic acid; lithospermic acid,.",

author = "Hiroshi Kohda and Osamu Takeda and Seiji Tanaka and Kazuo Yamasaki and Atsushi Yamashita and Tomonori Kurokawa and Sadahiko Ishibashi",

year = "1989",

doi = "10.1248/cpb.37.1287",

language = "英語",

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pages = "1287--1290",

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T1 - Isolation of Inhibitors of Adenylate Cyclase from Dan-shen, the Root of Salvia miltiorrhiza

AU - Kohda, Hiroshi

AU - Takeda, Osamu

AU - Tanaka, Seiji

AU - Yamasaki, Kazuo

AU - Yamashita, Atsushi

AU - Kurokawa, Tomonori

AU - Ishibashi, Sadahiko

PY - 1989

Y1 - 1989

N2 - The effect of dan-shen extract, the root of Salvia miltiorrhiza, on adenylate cyclase was investigated in both rat brain and rat erythrocytes. The EtOAc fraction of the MeOH extract was proved to have significant inhibitory activity. Potent inhibitory principles in the EtOAc fraction were isolated and identified as 4 polyphenolic acids, rosemarinic acid, lithospermic acid, and their methyl ester derivatives. dan-shen; Salvia miltiorrhiza; adenylate cyclase; rosemarinic acid; lithospermic acid,.

AB - The effect of dan-shen extract, the root of Salvia miltiorrhiza, on adenylate cyclase was investigated in both rat brain and rat erythrocytes. The EtOAc fraction of the MeOH extract was proved to have significant inhibitory activity. Potent inhibitory principles in the EtOAc fraction were isolated and identified as 4 polyphenolic acids, rosemarinic acid, lithospermic acid, and their methyl ester derivatives. dan-shen; Salvia miltiorrhiza; adenylate cyclase; rosemarinic acid; lithospermic acid,.

UR - https://www.scopus.com/pages/publications/0024334950

U2 - 10.1248/cpb.37.1287

DO - 10.1248/cpb.37.1287

M3 - 記事

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AN - SCOPUS:0024334950

SN - 0009-2363

VL - 37

SP - 1287

EP - 1290

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 5

ER -

Isolation of Inhibitors of Adenylate Cyclase from Dan-shen, the Root of Salvia miltiorrhiza

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