Class II transactivator suppresses transcription of thyroid-specific genes

Atsumi Mori-Aoki; Michelle Pietrarelli; Minoru Nakazato; Patrizio Caturegli; Leonard D. Kohn; Koichi Suzuki

doi:10.1006/bbrc.2000.3769

Class II transactivator suppresses transcription of thyroid-specific genes

Atsumi Mori-Aoki
, Michelle Pietrarelli
, Minoru Nakazato
, Patrizio Caturegli
, Leonard D. Kohn
, Koichi Suzuki

National Institutes of Health
Johns Hopkins University

研究成果: ジャーナルへの寄稿 › 記事 › 査読

19 被引用数 (Scopus)

抄録

Class II transactivator (CIITA) is the master regulator of MHC class II genes, and mediates their induction by interferon gamma (IFNγ). To study the role of CIITA in modulating the expression of thyroid-specific genes, we cloned the full-length rat CIITA and use it to transfect a rat thyroid cell line. We found that only one type of CIITA, type IV, is induced in thyroid cells upon IFNγ stimulation, and that CIITA is capable not only of inducing the expression of MHC genes in the thyroid, but also of differentially suppressing the expression of thyroid-specific genes. These findings suggest new avenues for the development of thyroid autoimmune diseases. (C) 2000 Academic Press.

本文言語	英語
ページ（範囲）	58-62
ページ数	5
ジャーナル	Biochemical and Biophysical Research Communications
巻	278
号	1
DOI	https://doi.org/10.1006/bbrc.2000.3769
出版ステータス	出版済み - 11 11月 2000
外部発表	はい

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title = "Class II transactivator suppresses transcription of thyroid-specific genes",

abstract = "Class II transactivator (CIITA) is the master regulator of MHC class II genes, and mediates their induction by interferon gamma (IFNγ). To study the role of CIITA in modulating the expression of thyroid-specific genes, we cloned the full-length rat CIITA and use it to transfect a rat thyroid cell line. We found that only one type of CIITA, type IV, is induced in thyroid cells upon IFNγ stimulation, and that CIITA is capable not only of inducing the expression of MHC genes in the thyroid, but also of differentially suppressing the expression of thyroid-specific genes. These findings suggest new avenues for the development of thyroid autoimmune diseases. (C) 2000 Academic Press.",

keywords = "Antigen presentation, Autoimmunity, Gene regulation, MHC, Thyroid, Transcription factors",

author = "Atsumi Mori-Aoki and Michelle Pietrarelli and Minoru Nakazato and Patrizio Caturegli and Kohn, \{Leonard D.\} and Koichi Suzuki",

year = "2000",

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doi = "10.1006/bbrc.2000.3769",

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T1 - Class II transactivator suppresses transcription of thyroid-specific genes

AU - Mori-Aoki, Atsumi

AU - Pietrarelli, Michelle

AU - Nakazato, Minoru

AU - Caturegli, Patrizio

AU - Kohn, Leonard D.

AU - Suzuki, Koichi

PY - 2000/11/11

Y1 - 2000/11/11

N2 - Class II transactivator (CIITA) is the master regulator of MHC class II genes, and mediates their induction by interferon gamma (IFNγ). To study the role of CIITA in modulating the expression of thyroid-specific genes, we cloned the full-length rat CIITA and use it to transfect a rat thyroid cell line. We found that only one type of CIITA, type IV, is induced in thyroid cells upon IFNγ stimulation, and that CIITA is capable not only of inducing the expression of MHC genes in the thyroid, but also of differentially suppressing the expression of thyroid-specific genes. These findings suggest new avenues for the development of thyroid autoimmune diseases. (C) 2000 Academic Press.

AB - Class II transactivator (CIITA) is the master regulator of MHC class II genes, and mediates their induction by interferon gamma (IFNγ). To study the role of CIITA in modulating the expression of thyroid-specific genes, we cloned the full-length rat CIITA and use it to transfect a rat thyroid cell line. We found that only one type of CIITA, type IV, is induced in thyroid cells upon IFNγ stimulation, and that CIITA is capable not only of inducing the expression of MHC genes in the thyroid, but also of differentially suppressing the expression of thyroid-specific genes. These findings suggest new avenues for the development of thyroid autoimmune diseases. (C) 2000 Academic Press.

KW - Antigen presentation

KW - Autoimmunity

KW - Gene regulation

KW - MHC

KW - Thyroid

KW - Transcription factors

UR - https://www.scopus.com/pages/publications/0034638597

U2 - 10.1006/bbrc.2000.3769

DO - 10.1006/bbrc.2000.3769

M3 - 記事

C2 - 11071855

AN - SCOPUS:0034638597

SN - 0006-291X

VL - 278

SP - 58

EP - 62

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 1

ER -

Class II transactivator suppresses transcription of thyroid-specific genes

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