Chronic active Epstein-Barr virus infection (CAEBV) successfully treated with allogeneic peripheral blood stem cell transplantation

T. Taketani; A. Kikuchi; J. Inatomi; R. Hanada; H. Kawaguchi; K. Ida; T. Oh-Ishi; T. Arai; H. Kishimoto; K. Yamamoto

doi:10.1038/sj/bmt/1703392

Chronic active Epstein-Barr virus infection (CAEBV) successfully treated with allogeneic peripheral blood stem cell transplantation

T. Taketani
, A. Kikuchi
, J. Inatomi
, R. Hanada
, H. Kawaguchi
, K. Ida
, T. Oh-Ishi
, T. Arai
, H. Kishimoto
, K. Yamamoto

Saitama Children's Medical Center

研究成果: ジャーナルへの寄稿 › 記事 › 査読

26 被引用数 (Scopus)

抄録

We report a pediatric case of CAEBV and T cell-based Hodgkin's-like disease successfully treated with allo PBSCT from an HLA-matched sibling. The diagnosis of CAEBV was made from clinical signs and the presence of the EBV genome in PBMC and tumor cells. Conditioning with busulfan (BU) + etoposide (VP16) + cyclophosphamide (CY) was effective and well tolerated. EBV was totally eradicated by 3 months after allo PBSCT. Although she suffered from chronic GVHD of the liver, she has been well and free of disease for 47 months since PBSCT. We suggest allo PBSCT for CAEBV as a potent therapeutic strategy for eradication of the EBV genome and allowing immunological reconstitution.

本文言語	英語
ページ（範囲）	531-533
ページ数	3
ジャーナル	Bone Marrow Transplantation
巻	29
号	6
DOI	https://doi.org/10.1038/sj/bmt/1703392
出版ステータス	出版済み - 2002
外部発表	はい

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引用スタイル

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title = "Chronic active Epstein-Barr virus infection (CAEBV) successfully treated with allogeneic peripheral blood stem cell transplantation",

abstract = "We report a pediatric case of CAEBV and T cell-based Hodgkin's-like disease successfully treated with allo PBSCT from an HLA-matched sibling. The diagnosis of CAEBV was made from clinical signs and the presence of the EBV genome in PBMC and tumor cells. Conditioning with busulfan (BU) + etoposide (VP16) + cyclophosphamide (CY) was effective and well tolerated. EBV was totally eradicated by 3 months after allo PBSCT. Although she suffered from chronic GVHD of the liver, she has been well and free of disease for 47 months since PBSCT. We suggest allo PBSCT for CAEBV as a potent therapeutic strategy for eradication of the EBV genome and allowing immunological reconstitution.",

keywords = "Allo PBSCT, CAEBV, EBV in situ hybridization, Malignant lymphoma",

author = "T. Taketani and A. Kikuchi and J. Inatomi and R. Hanada and H. Kawaguchi and K. Ida and T. Oh-Ishi and T. Arai and H. Kishimoto and K. Yamamoto",

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T1 - Chronic active Epstein-Barr virus infection (CAEBV) successfully treated with allogeneic peripheral blood stem cell transplantation

AU - Taketani, T.

AU - Kikuchi, A.

AU - Inatomi, J.

AU - Hanada, R.

AU - Kawaguchi, H.

AU - Ida, K.

AU - Oh-Ishi, T.

AU - Arai, T.

AU - Kishimoto, H.

AU - Yamamoto, K.

PY - 2002

Y1 - 2002

N2 - We report a pediatric case of CAEBV and T cell-based Hodgkin's-like disease successfully treated with allo PBSCT from an HLA-matched sibling. The diagnosis of CAEBV was made from clinical signs and the presence of the EBV genome in PBMC and tumor cells. Conditioning with busulfan (BU) + etoposide (VP16) + cyclophosphamide (CY) was effective and well tolerated. EBV was totally eradicated by 3 months after allo PBSCT. Although she suffered from chronic GVHD of the liver, she has been well and free of disease for 47 months since PBSCT. We suggest allo PBSCT for CAEBV as a potent therapeutic strategy for eradication of the EBV genome and allowing immunological reconstitution.

AB - We report a pediatric case of CAEBV and T cell-based Hodgkin's-like disease successfully treated with allo PBSCT from an HLA-matched sibling. The diagnosis of CAEBV was made from clinical signs and the presence of the EBV genome in PBMC and tumor cells. Conditioning with busulfan (BU) + etoposide (VP16) + cyclophosphamide (CY) was effective and well tolerated. EBV was totally eradicated by 3 months after allo PBSCT. Although she suffered from chronic GVHD of the liver, she has been well and free of disease for 47 months since PBSCT. We suggest allo PBSCT for CAEBV as a potent therapeutic strategy for eradication of the EBV genome and allowing immunological reconstitution.

KW - Allo PBSCT

KW - CAEBV

KW - EBV in situ hybridization

KW - Malignant lymphoma

UR - https://www.scopus.com/pages/publications/0036240613

U2 - 10.1038/sj/bmt/1703392

DO - 10.1038/sj/bmt/1703392

M3 - 記事

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AN - SCOPUS:0036240613

SN - 0268-3369

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JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

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ER -