Vitamin Transport Across the Blood-Retinal Barrier: Focus on Vitamins C, E, and Biotin

Ken ichi Hosoya; Yoshiyuki Kubo

doi:10.1016/B978-0-12-401717-7.00032-0

Vitamin Transport Across the Blood-Retinal Barrier: Focus on Vitamins C, E, and Biotin

Ken ichi Hosoya
, Yoshiyuki Kubo

University of Toyama

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

Vitamins are required as a vital nutrient by a number of organs including the retina. Nutrient transport from the circulating blood to the retina is regulated by the membrane permeability of the blood-retinal barrier (BRB), which forms complex tight junctions of retinal capillary endothelial cells (inner BRB) and retinal pigment epithelial cells (outer BRB). Since the BRB limits paracellular passive diffusion, transporters play a role in vitamin transport from the circulating blood to the retina. This chapter focuses on how vitamins C, E, and biotin are transferred to the retina across the BRB.

Original language	English
Title of host publication	Handbook of Nutrition, Diet and the Eye
Publisher	Elsevier Inc.
Pages	321-329
Number of pages	9
ISBN (Electronic)	9780124046061
ISBN (Print)	9780124017177
DOIs	https://doi.org/10.1016/B978-0-12-401717-7.00032-0
State	Published - 10 Apr 2014
Externally published	Yes

Keywords

Ascorbic acid
Biotin
Blood-retinal barrier
Carrier-mediated transport
Dehydroascorbic acid
α-tocopherol, transporter

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10.1016/B978-0-12-401717-7.00032-0

Cite this

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title = "Vitamin Transport Across the Blood-Retinal Barrier: Focus on Vitamins C, E, and Biotin",

abstract = "Vitamins are required as a vital nutrient by a number of organs including the retina. Nutrient transport from the circulating blood to the retina is regulated by the membrane permeability of the blood-retinal barrier (BRB), which forms complex tight junctions of retinal capillary endothelial cells (inner BRB) and retinal pigment epithelial cells (outer BRB). Since the BRB limits paracellular passive diffusion, transporters play a role in vitamin transport from the circulating blood to the retina. This chapter focuses on how vitamins C, E, and biotin are transferred to the retina across the BRB.",

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T1 - Vitamin Transport Across the Blood-Retinal Barrier

T2 - Focus on Vitamins C, E, and Biotin

AU - Hosoya, Ken ichi

AU - Kubo, Yoshiyuki

PY - 2014/4/10

Y1 - 2014/4/10

N2 - Vitamins are required as a vital nutrient by a number of organs including the retina. Nutrient transport from the circulating blood to the retina is regulated by the membrane permeability of the blood-retinal barrier (BRB), which forms complex tight junctions of retinal capillary endothelial cells (inner BRB) and retinal pigment epithelial cells (outer BRB). Since the BRB limits paracellular passive diffusion, transporters play a role in vitamin transport from the circulating blood to the retina. This chapter focuses on how vitamins C, E, and biotin are transferred to the retina across the BRB.

AB - Vitamins are required as a vital nutrient by a number of organs including the retina. Nutrient transport from the circulating blood to the retina is regulated by the membrane permeability of the blood-retinal barrier (BRB), which forms complex tight junctions of retinal capillary endothelial cells (inner BRB) and retinal pigment epithelial cells (outer BRB). Since the BRB limits paracellular passive diffusion, transporters play a role in vitamin transport from the circulating blood to the retina. This chapter focuses on how vitamins C, E, and biotin are transferred to the retina across the BRB.

KW - Ascorbic acid

KW - Biotin

KW - Blood-retinal barrier

KW - Carrier-mediated transport

KW - Dehydroascorbic acid

KW - α-tocopherol, transporter

UR - https://www.scopus.com/pages/publications/84943327304

U2 - 10.1016/B978-0-12-401717-7.00032-0

DO - 10.1016/B978-0-12-401717-7.00032-0

M3 - 章

AN - SCOPUS:84943327304

SN - 9780124017177

SP - 321

EP - 329

BT - Handbook of Nutrition, Diet and the Eye

PB - Elsevier Inc.

ER -

Vitamin Transport Across the Blood-Retinal Barrier: Focus on Vitamins C, E, and Biotin

Abstract

Keywords

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