The significance of phosphorylated heat shock protein 27 on the prognosis of pancreatic cancer

Mitsuru Okuno; Ichiro Yasuda; Seiji Adachi; Masanori Nakashima; Junji Kawaguchi; Shinpei Doi; Takuji Iwashita; Yoshinobu Hirose; Osamu Kozawa; Naoki Yoshimi; Masahito Shimizu; Hisataka Moriwaki

doi:10.18632/oncotarget.7424

The significance of phosphorylated heat shock protein 27 on the prognosis of pancreatic cancer

Mitsuru Okuno, Ichiro Yasuda, Seiji Adachi, Masanori Nakashima, Junji Kawaguchi, Shinpei Doi, Takuji Iwashita, Yoshinobu Hirose, Osamu Kozawa, Naoki Yoshimi, Masahito Shimizu, Hisataka Moriwaki

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Background and Aim: The precise role of phosphorylated heat shock protein (HSP) 27 (p-HSP27) in pancreatic cancer remains to be elucidated. The aim of this study was to investigate whether the expression of p-HSP27 predicts the prognosis of patients with pancreatic cancer. Methods: We retrospectively assessed 49 biopsied pancreatic cancer tissue samples that were obtained prior to the treatment with gemcitabine. The correlations between p-HSP27 and the clinicopathological characteristics were analyzed. Results: p-HSP27 was not correlated with the response to chemotherapy or histological type. However, the median survival time was significantly longer in the patients with high p-HSP27 (275 days, n = 18) than those with low p-HSP27 (205 days, n = 31) (P = 0.0158). A multivariate Cox proportional hazards regression analysis revealed that low p-HSP27 predicted a worse prognosis. Conclusions: Higher p-HSP27 expression before chemotherapy was correlated with better survival, indicating that p-HSP27 expression could be used to predict the prognosis of pancreatic cancer.

Original language	English
Pages (from-to)	14291-14299
Number of pages	9
Journal	Oncotarget
Volume	7
Issue number	12
DOIs	https://doi.org/10.18632/oncotarget.7424
State	Published - 22 Mar 2016
Externally published	Yes

Keywords

HSP27
Pancreatic cancer
Phosphorylation
Prognosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.18632/oncotarget.7424

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title = "The significance of phosphorylated heat shock protein 27 on the prognosis of pancreatic cancer",

abstract = "Background and Aim: The precise role of phosphorylated heat shock protein (HSP) 27 (p-HSP27) in pancreatic cancer remains to be elucidated. The aim of this study was to investigate whether the expression of p-HSP27 predicts the prognosis of patients with pancreatic cancer. Methods: We retrospectively assessed 49 biopsied pancreatic cancer tissue samples that were obtained prior to the treatment with gemcitabine. The correlations between p-HSP27 and the clinicopathological characteristics were analyzed. Results: p-HSP27 was not correlated with the response to chemotherapy or histological type. However, the median survival time was significantly longer in the patients with high p-HSP27 (275 days, n = 18) than those with low p-HSP27 (205 days, n = 31) (P = 0.0158). A multivariate Cox proportional hazards regression analysis revealed that low p-HSP27 predicted a worse prognosis. Conclusions: Higher p-HSP27 expression before chemotherapy was correlated with better survival, indicating that p-HSP27 expression could be used to predict the prognosis of pancreatic cancer.",

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author = "Mitsuru Okuno and Ichiro Yasuda and Seiji Adachi and Masanori Nakashima and Junji Kawaguchi and Shinpei Doi and Takuji Iwashita and Yoshinobu Hirose and Osamu Kozawa and Naoki Yoshimi and Masahito Shimizu and Hisataka Moriwaki",

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doi = "10.18632/oncotarget.7424",

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AU - Okuno, Mitsuru

AU - Yasuda, Ichiro

AU - Adachi, Seiji

AU - Nakashima, Masanori

AU - Kawaguchi, Junji

AU - Doi, Shinpei

AU - Iwashita, Takuji

AU - Hirose, Yoshinobu

AU - Kozawa, Osamu

AU - Yoshimi, Naoki

AU - Shimizu, Masahito

AU - Moriwaki, Hisataka

PY - 2016/3/22

Y1 - 2016/3/22

N2 - Background and Aim: The precise role of phosphorylated heat shock protein (HSP) 27 (p-HSP27) in pancreatic cancer remains to be elucidated. The aim of this study was to investigate whether the expression of p-HSP27 predicts the prognosis of patients with pancreatic cancer. Methods: We retrospectively assessed 49 biopsied pancreatic cancer tissue samples that were obtained prior to the treatment with gemcitabine. The correlations between p-HSP27 and the clinicopathological characteristics were analyzed. Results: p-HSP27 was not correlated with the response to chemotherapy or histological type. However, the median survival time was significantly longer in the patients with high p-HSP27 (275 days, n = 18) than those with low p-HSP27 (205 days, n = 31) (P = 0.0158). A multivariate Cox proportional hazards regression analysis revealed that low p-HSP27 predicted a worse prognosis. Conclusions: Higher p-HSP27 expression before chemotherapy was correlated with better survival, indicating that p-HSP27 expression could be used to predict the prognosis of pancreatic cancer.

AB - Background and Aim: The precise role of phosphorylated heat shock protein (HSP) 27 (p-HSP27) in pancreatic cancer remains to be elucidated. The aim of this study was to investigate whether the expression of p-HSP27 predicts the prognosis of patients with pancreatic cancer. Methods: We retrospectively assessed 49 biopsied pancreatic cancer tissue samples that were obtained prior to the treatment with gemcitabine. The correlations between p-HSP27 and the clinicopathological characteristics were analyzed. Results: p-HSP27 was not correlated with the response to chemotherapy or histological type. However, the median survival time was significantly longer in the patients with high p-HSP27 (275 days, n = 18) than those with low p-HSP27 (205 days, n = 31) (P = 0.0158). A multivariate Cox proportional hazards regression analysis revealed that low p-HSP27 predicted a worse prognosis. Conclusions: Higher p-HSP27 expression before chemotherapy was correlated with better survival, indicating that p-HSP27 expression could be used to predict the prognosis of pancreatic cancer.

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KW - Pancreatic cancer

KW - Phosphorylation

KW - Prognosis

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The significance of phosphorylated heat shock protein 27 on the prognosis of pancreatic cancer

Abstract

Keywords

UN SDGs

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