The base in four types of lidocaine preparation (formulated in hospital)

Hisayo Yamaoka; Moemi Saito; Keiji Maruyama; Tamaki Watanabe; Kazuo Maruyama; Ryo Suzuki; Shigekazu Watanabe; Masatoshi Tsuchiya; Yoshitaka Uchida; Masato Mochizuki; Tomoyo Yamanobe; Keiko Yamaoka; Shinichi Hirabayashi

doi:10.1248/yakushi.13-00174

The base in four types of lidocaine preparation (formulated in hospital)

Hisayo Yamaoka, Moemi Saito, Keiji Maruyama, Tamaki Watanabe, Kazuo Maruyama, Ryo Suzuki, Shigekazu Watanabe, Masatoshi Tsuchiya, Yoshitaka Uchida, Masato Mochizuki, Tomoyo Yamanobe, Keiko Yamaoka, Shinichi Hirabayashi

Faculty of Pharmaceutical Sciences

Teikyo University

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

PL cream (combination of lidocaine and procaine) was launched on the market in April 2012 in Japan. We investigated differences in the anesthetic effect by employing two types of base: Carbopol and methylcellulose. Electron microscopy showed a distinct difference in appearance: densely-scattered, fine particles for Carbopol and sparse, large particles for methylcellulose. Accordingly, the extensibility of the cream was significantly greater at 4 and 25 degrees centigrade for methylcellulose, but was greater at 34 degrees centigrade for Carbopol. The steady flow viscosity (1 s^-1) was greater for the Carbopol than methylcellulose base. The difference in the cutaneous permeability between the two bases increased over time: the methylcellulose base was removed at 90 min after application and, 30 min later, showed a significant difference. These results suggest that the methylcellulose base has a superior anesthetic effect in clinical settings.

Original language	English
Pages (from-to)	249-258
Number of pages	10
Journal	Yakugaku Zasshi
Volume	134
Issue number	2
DOIs	https://doi.org/10.1248/yakushi.13-00174
State	Published - 2014

Keywords

7%
Carbopol (CP)
Ductility
Lidocaine cream
Methyl cellulose (MC)
Pain vision
Permeability of the skin (mouse)
Viscosity

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10.1248/yakushi.13-00174

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title = "The base in four types of lidocaine preparation (formulated in hospital)",

abstract = "PL cream (combination of lidocaine and procaine) was launched on the market in April 2012 in Japan. We investigated differences in the anesthetic effect by employing two types of base: Carbopol and methylcellulose. Electron microscopy showed a distinct difference in appearance: densely-scattered, fine particles for Carbopol and sparse, large particles for methylcellulose. Accordingly, the extensibility of the cream was significantly greater at 4 and 25 degrees centigrade for methylcellulose, but was greater at 34 degrees centigrade for Carbopol. The steady flow viscosity (1 s-1) was greater for the Carbopol than methylcellulose base. The difference in the cutaneous permeability between the two bases increased over time: the methylcellulose base was removed at 90 min after application and, 30 min later, showed a significant difference. These results suggest that the methylcellulose base has a superior anesthetic effect in clinical settings.",

keywords = "7\%, Carbopol (CP), Ductility, Lidocaine cream, Methyl cellulose (MC), Pain vision, Permeability of the skin (mouse), Viscosity",

author = "Hisayo Yamaoka and Moemi Saito and Keiji Maruyama and Tamaki Watanabe and Kazuo Maruyama and Ryo Suzuki and Shigekazu Watanabe and Masatoshi Tsuchiya and Yoshitaka Uchida and Masato Mochizuki and Tomoyo Yamanobe and Keiko Yamaoka and Shinichi Hirabayashi",

year = "2014",

doi = "10.1248/yakushi.13-00174",

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pages = "249--258",

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T1 - The base in four types of lidocaine preparation (formulated in hospital)

AU - Yamaoka, Hisayo

AU - Saito, Moemi

AU - Maruyama, Keiji

AU - Watanabe, Tamaki

AU - Maruyama, Kazuo

AU - Suzuki, Ryo

AU - Watanabe, Shigekazu

AU - Tsuchiya, Masatoshi

AU - Uchida, Yoshitaka

AU - Mochizuki, Masato

AU - Yamanobe, Tomoyo

AU - Yamaoka, Keiko

AU - Hirabayashi, Shinichi

PY - 2014

Y1 - 2014

N2 - PL cream (combination of lidocaine and procaine) was launched on the market in April 2012 in Japan. We investigated differences in the anesthetic effect by employing two types of base: Carbopol and methylcellulose. Electron microscopy showed a distinct difference in appearance: densely-scattered, fine particles for Carbopol and sparse, large particles for methylcellulose. Accordingly, the extensibility of the cream was significantly greater at 4 and 25 degrees centigrade for methylcellulose, but was greater at 34 degrees centigrade for Carbopol. The steady flow viscosity (1 s-1) was greater for the Carbopol than methylcellulose base. The difference in the cutaneous permeability between the two bases increased over time: the methylcellulose base was removed at 90 min after application and, 30 min later, showed a significant difference. These results suggest that the methylcellulose base has a superior anesthetic effect in clinical settings.

AB - PL cream (combination of lidocaine and procaine) was launched on the market in April 2012 in Japan. We investigated differences in the anesthetic effect by employing two types of base: Carbopol and methylcellulose. Electron microscopy showed a distinct difference in appearance: densely-scattered, fine particles for Carbopol and sparse, large particles for methylcellulose. Accordingly, the extensibility of the cream was significantly greater at 4 and 25 degrees centigrade for methylcellulose, but was greater at 34 degrees centigrade for Carbopol. The steady flow viscosity (1 s-1) was greater for the Carbopol than methylcellulose base. The difference in the cutaneous permeability between the two bases increased over time: the methylcellulose base was removed at 90 min after application and, 30 min later, showed a significant difference. These results suggest that the methylcellulose base has a superior anesthetic effect in clinical settings.

KW - 7%

KW - Carbopol (CP)

KW - Ductility

KW - Lidocaine cream

KW - Methyl cellulose (MC)

KW - Pain vision

KW - Permeability of the skin (mouse)

KW - Viscosity

UR - https://www.scopus.com/pages/publications/84907284924

U2 - 10.1248/yakushi.13-00174

DO - 10.1248/yakushi.13-00174

M3 - 記事

C2 - 24492227

AN - SCOPUS:84907284924

SN - 0031-6903

VL - 134

SP - 249

EP - 258

JO - Yakugaku Zasshi

JF - Yakugaku Zasshi

IS - 2

ER -

The base in four types of lidocaine preparation (formulated in hospital)

Abstract

Keywords

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