Synthesis of glycopeptide dendrimer by a convergent method

Chinatsu Ozawa; Hironobu Hojo; Yuko Nakahara; Hidekazu Katayama; Kazuki Nabeshima; Toshiaki Akahane; Yoshiaki Nakahara

doi:10.1016/j.tet.2007.07.023

Synthesis of glycopeptide dendrimer by a convergent method

Chinatsu Ozawa
, Hironobu Hojo
, Yuko Nakahara
, Hidekazu Katayama
, Kazuki Nabeshima
, Toshiaki Akahane
, Yoshiaki Nakahara

Tokai University
Fukuoka University
ATTO Corporation

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Glycopeptide thioester comprising the sequence of extracellular matrix metalloproteinase inducer (emmprin) (34-58) was prepared and condensed with a dendrimer core having eight amino groups by the thioester method. The desired product, a glycopeptide dendrimer carrying an N-linked core pentasaccharide of about 30 kDa, was successfully isolated by preparative electrophoresis and characterized by mass analysis.

Original language	English
Pages (from-to)	9685-9690
Number of pages	6
Journal	Tetrahedron
Volume	63
Issue number	39
DOIs	https://doi.org/10.1016/j.tet.2007.07.023
State	Published - 24 Sep 2007
Externally published	Yes

Keywords

Glycopeptide dendrimer
Peptide thioester
Solid-phase synthesis

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10.1016/j.tet.2007.07.023

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title = "Synthesis of glycopeptide dendrimer by a convergent method",

abstract = "Glycopeptide thioester comprising the sequence of extracellular matrix metalloproteinase inducer (emmprin) (34-58) was prepared and condensed with a dendrimer core having eight amino groups by the thioester method. The desired product, a glycopeptide dendrimer carrying an N-linked core pentasaccharide of about 30 kDa, was successfully isolated by preparative electrophoresis and characterized by mass analysis.",

keywords = "Glycopeptide dendrimer, Peptide thioester, Solid-phase synthesis",

author = "Chinatsu Ozawa and Hironobu Hojo and Yuko Nakahara and Hidekazu Katayama and Kazuki Nabeshima and Toshiaki Akahane and Yoshiaki Nakahara",

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doi = "10.1016/j.tet.2007.07.023",

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T1 - Synthesis of glycopeptide dendrimer by a convergent method

AU - Ozawa, Chinatsu

AU - Hojo, Hironobu

AU - Nakahara, Yuko

AU - Katayama, Hidekazu

AU - Nabeshima, Kazuki

AU - Akahane, Toshiaki

AU - Nakahara, Yoshiaki

PY - 2007/9/24

Y1 - 2007/9/24

N2 - Glycopeptide thioester comprising the sequence of extracellular matrix metalloproteinase inducer (emmprin) (34-58) was prepared and condensed with a dendrimer core having eight amino groups by the thioester method. The desired product, a glycopeptide dendrimer carrying an N-linked core pentasaccharide of about 30 kDa, was successfully isolated by preparative electrophoresis and characterized by mass analysis.

AB - Glycopeptide thioester comprising the sequence of extracellular matrix metalloproteinase inducer (emmprin) (34-58) was prepared and condensed with a dendrimer core having eight amino groups by the thioester method. The desired product, a glycopeptide dendrimer carrying an N-linked core pentasaccharide of about 30 kDa, was successfully isolated by preparative electrophoresis and characterized by mass analysis.

KW - Glycopeptide dendrimer

KW - Peptide thioester

KW - Solid-phase synthesis

UR - https://www.scopus.com/pages/publications/34547731350

U2 - 10.1016/j.tet.2007.07.023

DO - 10.1016/j.tet.2007.07.023

M3 - 記事

AN - SCOPUS:34547731350

SN - 0040-4020

VL - 63

SP - 9685

EP - 9690

JO - Tetrahedron

JF - Tetrahedron

IS - 39

ER -

Synthesis of glycopeptide dendrimer by a convergent method

Abstract

Keywords

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