Synergic Suppressive Effect of Silodosin and Imidafenacin on Non-Voiding Bladder Contractions in Male Rats with Subacute Bladder Outlet Obstruction

Rino Sugiyama, Naoki Aizawa, Hiroki Ito, Tetsuya Fujimura, Motofumi Suzuki, Tohru Nakagawa, Hiroshi Fukuhara, Haruki Kume, Yukio Homma, Yasuhiko Igawa

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Objectives: To investigate single or combined effect of silodosin, an α1A-adrenoceptor antagonist, and imidafenacin, an antimuscarinic agent, on bladder function in a subacute bladder outlet obstruction (BOO) model of male rats. Methods: Partial BOO was created in male Wistar rats by ligating the urethra with a steel rod. On day 10 after surgery, when frequent voiding was most remarkable on voiding behavior measurement in a metabolic cage, cystometric investigations in a conscious restrained condition were conducted with cumulative intravenous administration of silodosin alone (0.1, 1, 10, and 100 µg/kg), imidafenacin alone (1, 3, and 10 µg/kg), or a combination of the two drugs. Results: When compared with the Sham rats, the BOO rats showed an increase in bladder capacity, residual volume, mean amplitude and the number of non-voiding contractions (NVCs), accompanied with an increase in bladder weight. In the BOO rats, silodosin alone at 100 µg/kg significantly decreased the number of NVCs, whereas imidafenacin alone at 3 and 10 µg/kg significantly decreased both the number and mean amplitude of NVCs. The combination administration with lower doses (silodosin at 10 µg/kg and imidafenacin at 1 µg/kg) significantly suppressed both the number and mean amplitude of NVCs. Conclusions: The present results indicate a suppressive effect of silodosin or imidafenacin alone and a synergic effect of the combination of these two drugs on NVCs in a subacute BOO model of male rats.

Original languageEnglish
Pages (from-to)94-101
Number of pages8
JournalLUTS: Lower Urinary Tract Symptoms
Volume9
Issue number2
DOIs
StatePublished - 1 May 2017
Externally publishedYes

Keywords

  • adrenergic alpha-1 receptor antagonists
  • bladder outlet obstruction
  • muscarinic antagonists
  • urinary bladder
  • Wistar rats

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