siRNA-mediated inhibition of phosphatidylinositol glycan class B (PIGB) confers resistance to methylmercury in HEK293 cells

Gi Wook Hwang; Tatsuya Hayashi; Kayoko Kita; Tsutomu Takahashi; Shusuke Kuge; Akira Naganuma

doi:10.2131/jts.32.581

siRNA-mediated inhibition of phosphatidylinositol glycan class B (PIGB) confers resistance to methylmercury in HEK293 cells

Gi Wook Hwang, Tatsuya Hayashi, Kayoko Kita, Tsutomu Takahashi, Shusuke Kuge, Akira Naganuma

Tohoku University

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We performed functional gene screening, using a siRNA library targeting 8,500 human genes, to identify proteins that are involved in the susceptibility of cells to methylmercury. Screening revealed that downregulation of the gene for phosphatidylinositol glycan class B (PIGB) by siRNA confers resistance to methylmercury in HEK293 cells.

Original language	English
Pages (from-to)	581-583
Number of pages	3
Journal	Journal of Toxicological Sciences
Volume	32
Issue number	5
DOIs	https://doi.org/10.2131/jts.32.581
State	Published - Dec 2007
Externally published	Yes

Keywords

HEK293 cells
Methylmercury
PIGB
Resistance
siRNA

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10.2131/jts.32.581

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abstract = "We performed functional gene screening, using a siRNA library targeting 8,500 human genes, to identify proteins that are involved in the susceptibility of cells to methylmercury. Screening revealed that downregulation of the gene for phosphatidylinositol glycan class B (PIGB) by siRNA confers resistance to methylmercury in HEK293 cells.",

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AU - Hwang, Gi Wook

AU - Hayashi, Tatsuya

AU - Kita, Kayoko

AU - Takahashi, Tsutomu

AU - Kuge, Shusuke

AU - Naganuma, Akira

PY - 2007/12

Y1 - 2007/12

N2 - We performed functional gene screening, using a siRNA library targeting 8,500 human genes, to identify proteins that are involved in the susceptibility of cells to methylmercury. Screening revealed that downregulation of the gene for phosphatidylinositol glycan class B (PIGB) by siRNA confers resistance to methylmercury in HEK293 cells.

AB - We performed functional gene screening, using a siRNA library targeting 8,500 human genes, to identify proteins that are involved in the susceptibility of cells to methylmercury. Screening revealed that downregulation of the gene for phosphatidylinositol glycan class B (PIGB) by siRNA confers resistance to methylmercury in HEK293 cells.

KW - HEK293 cells

KW - Methylmercury

KW - PIGB

KW - Resistance

KW - siRNA

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DO - 10.2131/jts.32.581

M3 - 記事

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AN - SCOPUS:38349044454

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ER -

siRNA-mediated inhibition of phosphatidylinositol glycan class B (PIGB) confers resistance to methylmercury in HEK293 cells

Abstract

Keywords

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