Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9

Fumihiko Takeshita; Ihsan Gursel; Ken J. Ishii; Koichi Suzuki; Mayda Gursel; Dennis M. Klinman

doi:10.1016/j.smim.2003.10.009

Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9

Fumihiko Takeshita
, Ihsan Gursel
, Ken J. Ishii
, Koichi Suzuki
, Mayda Gursel
, Dennis M. Klinman

United States Food and Drug Administration

Research output: Contribution to journal › Article › peer-review

167 Scopus citations

Abstract

Synthetic oligodeoxynucleotides (ODN) expressing non-methylated "CpG motifs" patterned after those present in bacterial DNA have characteristic immunomodulatory effects. CpG DNA is recognized as a pathogen-associated molecular pattern, and triggers a rapid innate immune response. CpG ODN are being harnessed for a variety of therapeutic uses, including as immune adjuvants, for cancer therapy, as anti-allergens, and as immunoprotective agents. The signal transduction pathway mediated by the engagement of CpG DNA with Toll-like receptor 9 (TLR9) is shared with other members of the TLR family. Recent studies demonstrate that formation and maturation of CpG DNA-containing endosomes are regulated by phosphatidylinositol 3 kinases and the Ras-associated GTP-binding protein, Rab5, which are essential for the initiation of TLR9-mediated signaling.

Original language	English
Pages (from-to)	17-22
Number of pages	6
Journal	Seminars in Immunology
Volume	16
Issue number	1
DOIs	https://doi.org/10.1016/j.smim.2003.10.009
State	Published - Feb 2004
Externally published	Yes

Keywords

CpG DNA
PAMP
Signal transduction
TLR 9

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.smim.2003.10.009

Cite this

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title = "Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9",

abstract = "Synthetic oligodeoxynucleotides (ODN) expressing non-methylated {"}CpG motifs{"} patterned after those present in bacterial DNA have characteristic immunomodulatory effects. CpG DNA is recognized as a pathogen-associated molecular pattern, and triggers a rapid innate immune response. CpG ODN are being harnessed for a variety of therapeutic uses, including as immune adjuvants, for cancer therapy, as anti-allergens, and as immunoprotective agents. The signal transduction pathway mediated by the engagement of CpG DNA with Toll-like receptor 9 (TLR9) is shared with other members of the TLR family. Recent studies demonstrate that formation and maturation of CpG DNA-containing endosomes are regulated by phosphatidylinositol 3 kinases and the Ras-associated GTP-binding protein, Rab5, which are essential for the initiation of TLR9-mediated signaling.",

keywords = "CpG DNA, PAMP, Signal transduction, TLR 9",

author = "Fumihiko Takeshita and Ihsan Gursel and Ishii, \{Ken J.\} and Koichi Suzuki and Mayda Gursel and Klinman, \{Dennis M.\}",

year = "2004",

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doi = "10.1016/j.smim.2003.10.009",

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AU - Takeshita, Fumihiko

AU - Gursel, Ihsan

AU - Ishii, Ken J.

AU - Suzuki, Koichi

AU - Gursel, Mayda

AU - Klinman, Dennis M.

PY - 2004/2

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N2 - Synthetic oligodeoxynucleotides (ODN) expressing non-methylated "CpG motifs" patterned after those present in bacterial DNA have characteristic immunomodulatory effects. CpG DNA is recognized as a pathogen-associated molecular pattern, and triggers a rapid innate immune response. CpG ODN are being harnessed for a variety of therapeutic uses, including as immune adjuvants, for cancer therapy, as anti-allergens, and as immunoprotective agents. The signal transduction pathway mediated by the engagement of CpG DNA with Toll-like receptor 9 (TLR9) is shared with other members of the TLR family. Recent studies demonstrate that formation and maturation of CpG DNA-containing endosomes are regulated by phosphatidylinositol 3 kinases and the Ras-associated GTP-binding protein, Rab5, which are essential for the initiation of TLR9-mediated signaling.

AB - Synthetic oligodeoxynucleotides (ODN) expressing non-methylated "CpG motifs" patterned after those present in bacterial DNA have characteristic immunomodulatory effects. CpG DNA is recognized as a pathogen-associated molecular pattern, and triggers a rapid innate immune response. CpG ODN are being harnessed for a variety of therapeutic uses, including as immune adjuvants, for cancer therapy, as anti-allergens, and as immunoprotective agents. The signal transduction pathway mediated by the engagement of CpG DNA with Toll-like receptor 9 (TLR9) is shared with other members of the TLR family. Recent studies demonstrate that formation and maturation of CpG DNA-containing endosomes are regulated by phosphatidylinositol 3 kinases and the Ras-associated GTP-binding protein, Rab5, which are essential for the initiation of TLR9-mediated signaling.

KW - CpG DNA

KW - PAMP

KW - Signal transduction

KW - TLR 9

UR - https://www.scopus.com/pages/publications/0742289969

U2 - 10.1016/j.smim.2003.10.009

DO - 10.1016/j.smim.2003.10.009

M3 - 記事

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AN - SCOPUS:0742289969

SN - 1044-5323

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JO - Seminars in Immunology

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ER -

Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9

Abstract

Keywords

UN SDGs

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