Regulatory T cells for tolerance

Kento Kawai; Masateru Uchiyama; Joanna Hester; Kathryn Wood; Fadi Issa

doi:10.1016/j.humimm.2017.12.013

Regulatory T cells for tolerance

Kento Kawai
, Masateru Uchiyama
, Joanna Hester
, Kathryn Wood
, Fadi Issa

University of Oxford

Research output: Contribution to journal › Review article › peer-review

81 Scopus citations

Abstract

Regulatory T cells (Tregs) are critical mediators of immune homeostasis and hold significant promise in the quest for transplantation tolerance. Progress has now reached a critical threshold as techniques for production of clinical therapies are optimised and Phase I/II clinical trials are in full swing. Initial safety and efficacy data are being reported, with trials assessing a number of different strategies for the introduction of Treg therapy. It is now more crucial than ever to elucidate further the function and behaviour of Tregs in vivo and ensure safe delivery. This review will discuss the current state of the art and future directions in Treg therapy.

Original language	English
Pages (from-to)	294-303
Number of pages	10
Journal	Human Immunology
Volume	79
Issue number	5
DOIs	https://doi.org/10.1016/j.humimm.2017.12.013
State	Published - May 2018
Externally published	Yes

Keywords

Humanized mouse
Immunosuppression
Regulatory T cells
T cell
Tolerance

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10.1016/j.humimm.2017.12.013

Cite this

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title = "Regulatory T cells for tolerance",

abstract = "Regulatory T cells (Tregs) are critical mediators of immune homeostasis and hold significant promise in the quest for transplantation tolerance. Progress has now reached a critical threshold as techniques for production of clinical therapies are optimised and Phase I/II clinical trials are in full swing. Initial safety and efficacy data are being reported, with trials assessing a number of different strategies for the introduction of Treg therapy. It is now more crucial than ever to elucidate further the function and behaviour of Tregs in vivo and ensure safe delivery. This review will discuss the current state of the art and future directions in Treg therapy.",

keywords = "Humanized mouse, Immunosuppression, Regulatory T cells, T cell, Tolerance",

author = "Kento Kawai and Masateru Uchiyama and Joanna Hester and Kathryn Wood and Fadi Issa",

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year = "2018",

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doi = "10.1016/j.humimm.2017.12.013",

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T1 - Regulatory T cells for tolerance

AU - Kawai, Kento

AU - Uchiyama, Masateru

AU - Hester, Joanna

AU - Wood, Kathryn

AU - Issa, Fadi

PY - 2018/5

Y1 - 2018/5

N2 - Regulatory T cells (Tregs) are critical mediators of immune homeostasis and hold significant promise in the quest for transplantation tolerance. Progress has now reached a critical threshold as techniques for production of clinical therapies are optimised and Phase I/II clinical trials are in full swing. Initial safety and efficacy data are being reported, with trials assessing a number of different strategies for the introduction of Treg therapy. It is now more crucial than ever to elucidate further the function and behaviour of Tregs in vivo and ensure safe delivery. This review will discuss the current state of the art and future directions in Treg therapy.

AB - Regulatory T cells (Tregs) are critical mediators of immune homeostasis and hold significant promise in the quest for transplantation tolerance. Progress has now reached a critical threshold as techniques for production of clinical therapies are optimised and Phase I/II clinical trials are in full swing. Initial safety and efficacy data are being reported, with trials assessing a number of different strategies for the introduction of Treg therapy. It is now more crucial than ever to elucidate further the function and behaviour of Tregs in vivo and ensure safe delivery. This review will discuss the current state of the art and future directions in Treg therapy.

KW - Humanized mouse

KW - Immunosuppression

KW - Regulatory T cells

KW - T cell

KW - Tolerance

UR - https://www.scopus.com/pages/publications/85040673452

U2 - 10.1016/j.humimm.2017.12.013

DO - 10.1016/j.humimm.2017.12.013

M3 - 総説

C2 - 29288698

AN - SCOPUS:85040673452

SN - 0198-8859

VL - 79

SP - 294

EP - 303

JO - Human Immunology

JF - Human Immunology

IS - 5

ER -

Regulatory T cells for tolerance

Abstract

Keywords

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