Platelet derived growth factor regulates ABCA1 expression in vascular smooth muscle cells

Sachi Nagao; Koji Murao; Hitomi Imachi; Wen Ming Cao; Xiao Yu; Junhua Li; Kensuke Matsumoto; Takamasa Nishiuchi; Rania A.M. Ahmed; Norman C.W. Wong; Kazumitsu Ueda; Toshihiko Ishida

doi:10.1016/j.febslet.2006.07.001

Platelet derived growth factor regulates ABCA1 expression in vascular smooth muscle cells

Sachi Nagao
, Koji Murao
, Hitomi Imachi
, Wen Ming Cao
, Xiao Yu
, Junhua Li
, Kensuke Matsumoto
, Takamasa Nishiuchi
, Rania A.M. Ahmed
, Norman C.W. Wong
, Kazumitsu Ueda
, Toshihiko Ishida

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

The ATP-binding cassette transporter A1 (ABCA1) regulates lipid efflux from peripheral cells to High-density lipoprotein. The platelet-derived growth factor (PDGF) is a potent mitogen that enables vascular smooth muscle cells to participate in atherosclerosis. In this report, we showed that PDGF suppressed endogenous expression of ABCA1 in cultured vascular smooth muscle cells. Exposure of CRL-208 cells to PDGF elicited a rapid phosphorylation of a kinase downstream from PI3-K, Akt. The constitutively active form of both p110, a subunit of PI3-K, and Akt inhibited activity of the ABCA1 promoter. In conclusion, PI3-K-Akt pathways participate in PDGF-suppression of ABCA1 expression.

Original language	English
Pages (from-to)	4371-4376
Number of pages	6
Journal	FEBS Letters
Volume	580
Issue number	18
DOIs	https://doi.org/10.1016/j.febslet.2006.07.001
State	Published - 7 Aug 2006
Externally published	Yes

Keywords

ATP-binding cassette transporter A1
Platelet-derived growth factor
Protein kinase B
Smooth muscle cell

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10.1016/j.febslet.2006.07.001

Cite this

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title = "Platelet derived growth factor regulates ABCA1 expression in vascular smooth muscle cells",

abstract = "The ATP-binding cassette transporter A1 (ABCA1) regulates lipid efflux from peripheral cells to High-density lipoprotein. The platelet-derived growth factor (PDGF) is a potent mitogen that enables vascular smooth muscle cells to participate in atherosclerosis. In this report, we showed that PDGF suppressed endogenous expression of ABCA1 in cultured vascular smooth muscle cells. Exposure of CRL-208 cells to PDGF elicited a rapid phosphorylation of a kinase downstream from PI3-K, Akt. The constitutively active form of both p110, a subunit of PI3-K, and Akt inhibited activity of the ABCA1 promoter. In conclusion, PI3-K-Akt pathways participate in PDGF-suppression of ABCA1 expression.",

keywords = "ATP-binding cassette transporter A1, Platelet-derived growth factor, Protein kinase B, Smooth muscle cell",

author = "Sachi Nagao and Koji Murao and Hitomi Imachi and Cao, \{Wen Ming\} and Xiao Yu and Junhua Li and Kensuke Matsumoto and Takamasa Nishiuchi and Ahmed, \{Rania A.M.\} and Wong, \{Norman C.W.\} and Kazumitsu Ueda and Toshihiko Ishida",

year = "2006",

month = aug,

day = "7",

doi = "10.1016/j.febslet.2006.07.001",

language = "英語",

volume = "580",

pages = "4371--4376",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "John Wiley and Sons Inc",

number = "18",

}

TY - JOUR

T1 - Platelet derived growth factor regulates ABCA1 expression in vascular smooth muscle cells

AU - Nagao, Sachi

AU - Murao, Koji

AU - Imachi, Hitomi

AU - Cao, Wen Ming

AU - Yu, Xiao

AU - Li, Junhua

AU - Matsumoto, Kensuke

AU - Nishiuchi, Takamasa

AU - Ahmed, Rania A.M.

AU - Wong, Norman C.W.

AU - Ueda, Kazumitsu

AU - Ishida, Toshihiko

PY - 2006/8/7

Y1 - 2006/8/7

N2 - The ATP-binding cassette transporter A1 (ABCA1) regulates lipid efflux from peripheral cells to High-density lipoprotein. The platelet-derived growth factor (PDGF) is a potent mitogen that enables vascular smooth muscle cells to participate in atherosclerosis. In this report, we showed that PDGF suppressed endogenous expression of ABCA1 in cultured vascular smooth muscle cells. Exposure of CRL-208 cells to PDGF elicited a rapid phosphorylation of a kinase downstream from PI3-K, Akt. The constitutively active form of both p110, a subunit of PI3-K, and Akt inhibited activity of the ABCA1 promoter. In conclusion, PI3-K-Akt pathways participate in PDGF-suppression of ABCA1 expression.

AB - The ATP-binding cassette transporter A1 (ABCA1) regulates lipid efflux from peripheral cells to High-density lipoprotein. The platelet-derived growth factor (PDGF) is a potent mitogen that enables vascular smooth muscle cells to participate in atherosclerosis. In this report, we showed that PDGF suppressed endogenous expression of ABCA1 in cultured vascular smooth muscle cells. Exposure of CRL-208 cells to PDGF elicited a rapid phosphorylation of a kinase downstream from PI3-K, Akt. The constitutively active form of both p110, a subunit of PI3-K, and Akt inhibited activity of the ABCA1 promoter. In conclusion, PI3-K-Akt pathways participate in PDGF-suppression of ABCA1 expression.

KW - ATP-binding cassette transporter A1

KW - Platelet-derived growth factor

KW - Protein kinase B

KW - Smooth muscle cell

UR - https://www.scopus.com/pages/publications/33746334150

U2 - 10.1016/j.febslet.2006.07.001

DO - 10.1016/j.febslet.2006.07.001

M3 - 記事

C2 - 16854413

AN - SCOPUS:33746334150

SN - 0014-5793

VL - 580

SP - 4371

EP - 4376

JO - FEBS Letters

JF - FEBS Letters

IS - 18

ER -

Platelet derived growth factor regulates ABCA1 expression in vascular smooth muscle cells

Abstract

Keywords

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