PAF and PAF acetylhydrolase in the nervous system

Mitsuharu Hattori; Junken Aoki; Hiroyuki Arai; Keizo Inoue

doi:10.1016/0929-7855(96)00514-7

PAF and PAF acetylhydrolase in the nervous system

Mitsuharu Hattori
, Junken Aoki
, Hiroyuki Arai
, Keizo Inoue

The University of Tokyo

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

PAF acetylhydrolase is a key enzyme of PAF inactivation. Intracellular PAF acetylhydrolase isoform Ib is a heterotrimeric enzyme composed of α-, β- and γ-subunits. The β- and γ-subunits act as a catalytic unit and their amino acid sequences are homologous. The α-subunit is not essential for catalytic activity but is a product of the causative gene for Miller-Dicker lissencephaly, suggesting this subunit plays an important role in brain development.

Original language	English
Pages (from-to)	99-102
Number of pages	4
Journal	Journal of Lipid Mediators and Cell Signalling
Volume	14
Issue number	1-3
DOIs	https://doi.org/10.1016/0929-7855(96)00514-7
State	Published - Sep 1996
Externally published	Yes

Keywords

isoforms
Miller-Dicker lissencephaly
PAF acetylhydrolase
Zellweger syndrome

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10.1016/0929-7855(96)00514-7

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title = "PAF and PAF acetylhydrolase in the nervous system",

abstract = "PAF acetylhydrolase is a key enzyme of PAF inactivation. Intracellular PAF acetylhydrolase isoform Ib is a heterotrimeric enzyme composed of α-, β- and γ-subunits. The β- and γ-subunits act as a catalytic unit and their amino acid sequences are homologous. The α-subunit is not essential for catalytic activity but is a product of the causative gene for Miller-Dicker lissencephaly, suggesting this subunit plays an important role in brain development.",

keywords = "isoforms, Miller-Dicker lissencephaly, PAF acetylhydrolase, Zellweger syndrome",

author = "Mitsuharu Hattori and Junken Aoki and Hiroyuki Arai and Keizo Inoue",

year = "1996",

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language = "英語",

volume = "14",

pages = "99--102",

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T1 - PAF and PAF acetylhydrolase in the nervous system

AU - Hattori, Mitsuharu

AU - Aoki, Junken

AU - Arai, Hiroyuki

AU - Inoue, Keizo

PY - 1996/9

Y1 - 1996/9

N2 - PAF acetylhydrolase is a key enzyme of PAF inactivation. Intracellular PAF acetylhydrolase isoform Ib is a heterotrimeric enzyme composed of α-, β- and γ-subunits. The β- and γ-subunits act as a catalytic unit and their amino acid sequences are homologous. The α-subunit is not essential for catalytic activity but is a product of the causative gene for Miller-Dicker lissencephaly, suggesting this subunit plays an important role in brain development.

AB - PAF acetylhydrolase is a key enzyme of PAF inactivation. Intracellular PAF acetylhydrolase isoform Ib is a heterotrimeric enzyme composed of α-, β- and γ-subunits. The β- and γ-subunits act as a catalytic unit and their amino acid sequences are homologous. The α-subunit is not essential for catalytic activity but is a product of the causative gene for Miller-Dicker lissencephaly, suggesting this subunit plays an important role in brain development.

KW - isoforms

KW - Miller-Dicker lissencephaly

KW - PAF acetylhydrolase

KW - Zellweger syndrome

UR - https://www.scopus.com/pages/publications/0030249718

U2 - 10.1016/0929-7855(96)00514-7

DO - 10.1016/0929-7855(96)00514-7

M3 - 記事

C2 - 8906551

AN - SCOPUS:0030249718

SN - 0929-7855

VL - 14

SP - 99

EP - 102

JO - Journal of Lipid Mediators and Cell Signalling

JF - Journal of Lipid Mediators and Cell Signalling

IS - 1-3

ER -

PAF and PAF acetylhydrolase in the nervous system

Abstract

Keywords

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