New-onset demyelination induced by infliximab therapy in two rheumatoid arthritis patients

Makoto Tanno; Ichiro Nakamura; Shunsuke Kobayashi; Kumiko Kurihara; Katsumi Ito

doi:10.1007/s10067-005-0097-x

New-onset demyelination induced by infliximab therapy in two rheumatoid arthritis patients

Makoto Tanno, Ichiro Nakamura, Shunsuke Kobayashi, Kumiko Kurihara, Katsumi Ito

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Therapies aimed at inhibiting tumor necrosis factor, a proinflammatory cytokine implicated in autoimmune disease, are effective for rheumatoid arthritis (RA) and Crohn's disease. We report two patients who newly developed multiple demyelinating lesions in the central nervous system in the course of infliximab therapy for active RA. Neurological symptoms and the number of gadolinium-diethylenetriamine pentaacetic acid-enhanced lesions in magnetic resonance imaging gradually diminished with steroid treatment.

Original language	English
Pages (from-to)	929-933
Number of pages	5
Journal	Clinical Rheumatology
Volume	25
Issue number	6
DOIs	https://doi.org/10.1007/s10067-005-0097-x
State	Published - Nov 2006
Externally published	Yes

Keywords

Demyelinating
Infliximab
Magnetic resonance imaging (MRI)
Multiple sclerosis
Rheumatoid arthritis
Tumor necrosis factor

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10067-005-0097-x

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title = "New-onset demyelination induced by infliximab therapy in two rheumatoid arthritis patients",

abstract = "Therapies aimed at inhibiting tumor necrosis factor, a proinflammatory cytokine implicated in autoimmune disease, are effective for rheumatoid arthritis (RA) and Crohn's disease. We report two patients who newly developed multiple demyelinating lesions in the central nervous system in the course of infliximab therapy for active RA. Neurological symptoms and the number of gadolinium-diethylenetriamine pentaacetic acid-enhanced lesions in magnetic resonance imaging gradually diminished with steroid treatment.",

keywords = "Demyelinating, Infliximab, Magnetic resonance imaging (MRI), Multiple sclerosis, Rheumatoid arthritis, Tumor necrosis factor",

author = "Makoto Tanno and Ichiro Nakamura and Shunsuke Kobayashi and Kumiko Kurihara and Katsumi Ito",

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AU - Nakamura, Ichiro

AU - Kobayashi, Shunsuke

AU - Kurihara, Kumiko

AU - Ito, Katsumi

PY - 2006/11

Y1 - 2006/11

N2 - Therapies aimed at inhibiting tumor necrosis factor, a proinflammatory cytokine implicated in autoimmune disease, are effective for rheumatoid arthritis (RA) and Crohn's disease. We report two patients who newly developed multiple demyelinating lesions in the central nervous system in the course of infliximab therapy for active RA. Neurological symptoms and the number of gadolinium-diethylenetriamine pentaacetic acid-enhanced lesions in magnetic resonance imaging gradually diminished with steroid treatment.

AB - Therapies aimed at inhibiting tumor necrosis factor, a proinflammatory cytokine implicated in autoimmune disease, are effective for rheumatoid arthritis (RA) and Crohn's disease. We report two patients who newly developed multiple demyelinating lesions in the central nervous system in the course of infliximab therapy for active RA. Neurological symptoms and the number of gadolinium-diethylenetriamine pentaacetic acid-enhanced lesions in magnetic resonance imaging gradually diminished with steroid treatment.

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KW - Infliximab

KW - Magnetic resonance imaging (MRI)

KW - Multiple sclerosis

KW - Rheumatoid arthritis

KW - Tumor necrosis factor

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New-onset demyelination induced by infliximab therapy in two rheumatoid arthritis patients

Abstract

Keywords

UN SDGs

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