Myocardial fatty acid metabolism in diabetic mice with 125I-BMIPP

Motoo Oshima; Shizuka Higashi; Yoshirou Kikuchi; Tatsuo Shirai; Tokuzou Yokokawa; Tatsuro Kaminaga; Hiroshi Yasukochi; Shigeru Furui

doi:10.1007/BF03164777

Myocardial fatty acid metabolism in diabetic mice with ¹²⁵I-BMIPP

Motoo Oshima
, Shizuka Higashi
, Yoshirou Kikuchi
, Tatsuo Shirai
, Tokuzou Yokokawa
, Tatsuro Kaminaga
, Hiroshi Yasukochi
, Shigeru Furui

Teikyo University

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

In patients with diabetes mellitus, the existence of diabetic cardiomyopathy was substantiated. This study was undertaken to evaluate the myocardiac fatty acid metabolism of diabetic mice (n = 21) and controls (n = 21) in ¹²⁵I-BMIPP in fasted and unfasted states. ¹²⁵I-BMIPP of 370 kBq was given and thirty minutes later, animals from both groups were killed. Samples of hearts, liver and other organs were removed, weighed and then counted in a scintillation counter. The percent injected dose/g of hearts of diabetic mice was significantly reduced compared to controls in unfasted (p < 0.05) and fasted (p < 0.01) groups. These findings may reflect impaired fatty acid utilization of the hearts in diabetic mice compared to controls.

Original language	English
Pages (from-to)	133-137
Number of pages	5
Journal	Annals of Nuclear Medicine
Volume	12
Issue number	3
DOIs	https://doi.org/10.1007/BF03164777
State	Published - 1998

Keywords

I-BMIPP
Diabetes mellitus
Diabetic cardiomyopathy
Fatty acid metabolism
Mouse

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/BF03164777

Cite this

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title = "Myocardial fatty acid metabolism in diabetic mice with 125I-BMIPP",

abstract = "In patients with diabetes mellitus, the existence of diabetic cardiomyopathy was substantiated. This study was undertaken to evaluate the myocardiac fatty acid metabolism of diabetic mice (n = 21) and controls (n = 21) in 125I-BMIPP in fasted and unfasted states. 125I-BMIPP of 370 kBq was given and thirty minutes later, animals from both groups were killed. Samples of hearts, liver and other organs were removed, weighed and then counted in a scintillation counter. The percent injected dose/g of hearts of diabetic mice was significantly reduced compared to controls in unfasted (p < 0.05) and fasted (p < 0.01) groups. These findings may reflect impaired fatty acid utilization of the hearts in diabetic mice compared to controls.",

keywords = "I-BMIPP, Diabetes mellitus, Diabetic cardiomyopathy, Fatty acid metabolism, Mouse",

author = "Motoo Oshima and Shizuka Higashi and Yoshirou Kikuchi and Tatsuo Shirai and Tokuzou Yokokawa and Tatsuro Kaminaga and Hiroshi Yasukochi and Shigeru Furui",

year = "1998",

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T1 - Myocardial fatty acid metabolism in diabetic mice with 125I-BMIPP

AU - Oshima, Motoo

AU - Higashi, Shizuka

AU - Kikuchi, Yoshirou

AU - Shirai, Tatsuo

AU - Yokokawa, Tokuzou

AU - Kaminaga, Tatsuro

AU - Yasukochi, Hiroshi

AU - Furui, Shigeru

PY - 1998

Y1 - 1998

N2 - In patients with diabetes mellitus, the existence of diabetic cardiomyopathy was substantiated. This study was undertaken to evaluate the myocardiac fatty acid metabolism of diabetic mice (n = 21) and controls (n = 21) in 125I-BMIPP in fasted and unfasted states. 125I-BMIPP of 370 kBq was given and thirty minutes later, animals from both groups were killed. Samples of hearts, liver and other organs were removed, weighed and then counted in a scintillation counter. The percent injected dose/g of hearts of diabetic mice was significantly reduced compared to controls in unfasted (p < 0.05) and fasted (p < 0.01) groups. These findings may reflect impaired fatty acid utilization of the hearts in diabetic mice compared to controls.

AB - In patients with diabetes mellitus, the existence of diabetic cardiomyopathy was substantiated. This study was undertaken to evaluate the myocardiac fatty acid metabolism of diabetic mice (n = 21) and controls (n = 21) in 125I-BMIPP in fasted and unfasted states. 125I-BMIPP of 370 kBq was given and thirty minutes later, animals from both groups were killed. Samples of hearts, liver and other organs were removed, weighed and then counted in a scintillation counter. The percent injected dose/g of hearts of diabetic mice was significantly reduced compared to controls in unfasted (p < 0.05) and fasted (p < 0.01) groups. These findings may reflect impaired fatty acid utilization of the hearts in diabetic mice compared to controls.

KW - I-BMIPP

KW - Diabetes mellitus

KW - Diabetic cardiomyopathy

KW - Fatty acid metabolism

KW - Mouse

UR - https://www.scopus.com/pages/publications/0031845790

U2 - 10.1007/BF03164777

DO - 10.1007/BF03164777

M3 - 記事

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JO - Annals of Nuclear Medicine

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