Modulation of oxidative burst of neutrophils by doxycycline in patients with acute myocardial infarction

Satoshi Takeshita; Yasuo Ono; Ken Kozuma; Masatoshi Suzuki; Yutaka Kawamura; Naoyuki Yokoyama; Taiji Furukawa; Takaaki Isshiki

doi:10.1093/jac/49.2.411

Modulation of oxidative burst of neutrophils by doxycycline in patients with acute myocardial infarction

Satoshi Takeshita
, Yasuo Ono
, Ken Kozuma
, Masatoshi Suzuki
, Yutaka Kawamura
, Naoyuki Yokoyama
, Taiji Furukawa
, Takaaki Isshiki

School of Medicine

Teikyo University

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

We investigated to what extent doxycycline hydrochloride (DOXY) can modify polymorphonuclear leucocyte (PMN) activity in patients with acute myocardial infarction (AMI). PMN activity was measured in blood samples obtained at 0, 15, 30 and 60 min after DOXY administration. In patients receiving saline, PMN activity did not change over 60 min. In contrast, patients receiving DOXY showed a ≥10% reduction in PMN activity at 30 and 60 min. These data support the use of DOXY to reduce myocardial cell damage by PMNs in patients with AMI.

Original language	English
Pages (from-to)	411-413
Number of pages	3
Journal	Journal of Antimicrobial Chemotherapy
Volume	49
Issue number	2
DOIs	https://doi.org/10.1093/jac/49.2.411
State	Published - 2002

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title = "Modulation of oxidative burst of neutrophils by doxycycline in patients with acute myocardial infarction",

abstract = "We investigated to what extent doxycycline hydrochloride (DOXY) can modify polymorphonuclear leucocyte (PMN) activity in patients with acute myocardial infarction (AMI). PMN activity was measured in blood samples obtained at 0, 15, 30 and 60 min after DOXY administration. In patients receiving saline, PMN activity did not change over 60 min. In contrast, patients receiving DOXY showed a ≥10\% reduction in PMN activity at 30 and 60 min. These data support the use of DOXY to reduce myocardial cell damage by PMNs in patients with AMI.",

author = "Satoshi Takeshita and Yasuo Ono and Ken Kozuma and Masatoshi Suzuki and Yutaka Kawamura and Naoyuki Yokoyama and Taiji Furukawa and Takaaki Isshiki",

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doi = "10.1093/jac/49.2.411",

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T1 - Modulation of oxidative burst of neutrophils by doxycycline in patients with acute myocardial infarction

AU - Takeshita, Satoshi

AU - Ono, Yasuo

AU - Kozuma, Ken

AU - Suzuki, Masatoshi

AU - Kawamura, Yutaka

AU - Yokoyama, Naoyuki

AU - Furukawa, Taiji

AU - Isshiki, Takaaki

PY - 2002

Y1 - 2002

N2 - We investigated to what extent doxycycline hydrochloride (DOXY) can modify polymorphonuclear leucocyte (PMN) activity in patients with acute myocardial infarction (AMI). PMN activity was measured in blood samples obtained at 0, 15, 30 and 60 min after DOXY administration. In patients receiving saline, PMN activity did not change over 60 min. In contrast, patients receiving DOXY showed a ≥10% reduction in PMN activity at 30 and 60 min. These data support the use of DOXY to reduce myocardial cell damage by PMNs in patients with AMI.

AB - We investigated to what extent doxycycline hydrochloride (DOXY) can modify polymorphonuclear leucocyte (PMN) activity in patients with acute myocardial infarction (AMI). PMN activity was measured in blood samples obtained at 0, 15, 30 and 60 min after DOXY administration. In patients receiving saline, PMN activity did not change over 60 min. In contrast, patients receiving DOXY showed a ≥10% reduction in PMN activity at 30 and 60 min. These data support the use of DOXY to reduce myocardial cell damage by PMNs in patients with AMI.

UR - https://www.scopus.com/pages/publications/0036181091

U2 - 10.1093/jac/49.2.411

DO - 10.1093/jac/49.2.411

M3 - 記事

C2 - 11815591

AN - SCOPUS:0036181091

SN - 0305-7453

VL - 49

SP - 411

EP - 413

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 2

ER -

Modulation of oxidative burst of neutrophils by doxycycline in patients with acute myocardial infarction

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