Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci

Meian He; Min Xu; Ben Zhang; Jun Liang; Peng Chen; Jong Young Lee; Todd A. Johnson; Huaixing Li; Xiaobo Yang; Juncheng Dai; Liming Liang; Lixuan Gui; Qibin Qi; Jinyan Huang; Yanping Li; Linda S. Adair; Tin Aung; Qiuyin Cai; Ching Yu Cheng; Myeong Chan Cho; Yoon Shin Cho; Minjie Chu; Bin Cui; Yu Tang Gao; Min Jin Go; Dongfeng Gu; Weiqiong Gu; Huan Guo; Yongchen Hao; Jie Hong; Zhibin Hu; Yanling Hu; Jianfeng Huang; Joo Yeon Hwang; Mohammad Kamran Ikram; Guangfu Jin; Dae Hee Kang; Chiea Chuen Khor; Bong Jo Kim; Hung Tae Kim; Michiaki Kubo; Jeannette Lee; Juyoung Lee; Nanette R. Lee; Ruoying Li; Jun Li; Jian Jun Liu; Jirong Longe; Wei Lu; Xiangfeng Lu; Xiaoping Miao; Yukinori Okada; Rick Twee Hee Ong; Gaokun Qiu; Mark Seielstad; Xueling Sim; Huaidong Song; Fumihiko Takeuchi; Toshihiro Tanaka; Phil R. Taylor; Laiyuan Wang; Weiqing Wang; Yiqin Wang; Chen Wu; Ying Wu; Yong Bing Xiang; Ken Yamamoto; Handong Yang; Ming Liao; Mitsuhiro Yokota; Terri Young; Xiaomin Zhang; Norihiro Kato; Qing K. Wang; Wei Zheng; Frank B. Hu; Dongxin Lin; Hongbing Shen; Yik Ying Teo; Zengnan Mo; Tien Yin Wong; Xu Lin; Karen L. Mohlke; Guang Ning; Tatsuhiko Tsunoda; Bok Ghee Han; Xiao Ou Shu; E. Shyong Tai; Tangchun Wu; Lu Qi

doi:10.1093/hmg/ddu583

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci

Meian He
, Min Xu
, Ben Zhang
, Jun Liang
, Peng Chen
, Jong Young Lee
, Todd A. Johnson
, Huaixing Li
, Xiaobo Yang
, Juncheng Dai
, Liming Liang
, Lixuan Gui
, Qibin Qi
, Jinyan Huang
, Yanping Li
, Linda S. Adair
, Tin Aung
, Qiuyin Cai
, Ching Yu Cheng
, Myeong Chan Cho

Yoon Shin Cho, Minjie Chu, Bin Cui, Yu Tang Gao, Min Jin Go, Dongfeng Gu, Weiqiong Gu, Huan Guo, Yongchen Hao, Jie Hong, Zhibin Hu, Yanling Hu, Jianfeng Huang, Joo Yeon Hwang, Mohammad Kamran Ikram, Guangfu Jin, Dae Hee Kang, Chiea Chuen Khor, Bong Jo Kim, Hung Tae Kim, Michiaki Kubo, Jeannette Lee, Juyoung Lee, Nanette R. Lee, Ruoying Li, Jun Li, Jian Jun Liu, Jirong Longe, Wei Lu, Xiangfeng Lu, Xiaoping Miao, Yukinori Okada, Rick Twee Hee Ong, Gaokun Qiu, Mark Seielstad, Xueling Sim, Huaidong Song, Fumihiko Takeuchi, Toshihiro Tanaka, Phil R. Taylor, Laiyuan Wang, Weiqing Wang, Yiqin Wang, Chen Wu, Ying Wu, Yong Bing Xiang, Ken Yamamoto, Handong Yang, Ming Liao, Mitsuhiro Yokota, Terri Young, Xiaomin Zhang, Norihiro Kato, Qing K. Wang, Wei Zheng, Frank B. Hu, Dongxin Lin, Hongbing Shen, Yik Ying Teo, Zengnan Mo, Tien Yin Wong, Xu Lin, Karen L. Mohlke, Guang Ning, Tatsuhiko Tsunoda, Bok Ghee Han, Xiao Ou Shu, E. Shyong Tai, Tangchun Wu, Lu Qi

Huazhong University of Science and Technology
Harvard University
Ministry of Health of People's Republic of China
Vanderbilt University
Xuzhou Central Hospital
National University of Singapore
Korea National Institute of Health
RIKEN
CAS - Shanghai Institute of Nutrition and Health
First Affiliated Hospital
Guangxi Medical University
Nanjing Medical University
University of North Carolina at Chapel Hill
Singapore National Eye Center
Duke National University
Shanghai Jiao Tong University
Chinese Academy of Medical Sciences
Erasmus University Rotterdam
MOH Holdings Pte Ltd.
Seoul National University
Agency for Science, Technology and Research, Singapore
University of San Carlos - Philippines
Shanghai Municipal Center for Disease Control and Prevention
University of Michigan, Ann Arbor
National Center for Global Health and Medicine
National Institutes of Health
Kyushu University
Hubei University of Medicine
Aichi Gakuin University
Duke University

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Abstract

Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A recent study showed high replicability of results from Europeans-based GWA studies in Asians; however, population-specific loci may exist due to distinct linkage disequilibrium patterns. We carried out a GWA meta-analysis in 93 926 individuals from East Asia. We identified 98 loci, including 17 novel and 81 previously reported loci, associated with height at P < 5 × 10^-8, together explaining 8.89% of phenotypic variance. Among the newly identified variants, 10 are commonly distributed (minor allele frequency, MAF > 5%) in Europeans, with comparable frequencies with in Asians, and 7 single-nucleotide polymorphisms are with low frequency (MAF < 5%) in Europeans. In addition, our data suggest that novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of height. The findings from this study considerably expand our knowledge of the genetic architecture of human height in Asians.

Original language	English
Pages (from-to)	1791-1800
Number of pages	10
Journal	Human Molecular Genetics
Volume	24
Issue number	6
DOIs	https://doi.org/10.1093/hmg/ddu583
State	Published - 15 Mar 2015
Externally published	Yes

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10.1093/hmg/ddu583

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He, M., Xu, M., Zhang, B., Liang, J., Chen, P., Lee, J. Y., Johnson, T. A., Li, H., Yang, X., Dai, J., Liang, L., Gui, L., Qi, Q., Huang, J., Li, Y., Adair, L. S., Aung, T., Cai, Q., Cheng, C. Y., ... Qi, L. (2015). Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. Human Molecular Genetics, 24(6), 1791-1800. https://doi.org/10.1093/hmg/ddu583

@article{52ce7e62f1c34e12b1edd3a643283814,

title = "Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci",

abstract = "Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A recent study showed high replicability of results from Europeans-based GWA studies in Asians; however, population-specific loci may exist due to distinct linkage disequilibrium patterns. We carried out a GWA meta-analysis in 93 926 individuals from East Asia. We identified 98 loci, including 17 novel and 81 previously reported loci, associated with height at P < 5 × 10-8, together explaining 8.89\% of phenotypic variance. Among the newly identified variants, 10 are commonly distributed (minor allele frequency, MAF > 5\%) in Europeans, with comparable frequencies with in Asians, and 7 single-nucleotide polymorphisms are with low frequency (MAF < 5\%) in Europeans. In addition, our data suggest that novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of height. The findings from this study considerably expand our knowledge of the genetic architecture of human height in Asians.",

author = "Meian He and Min Xu and Ben Zhang and Jun Liang and Peng Chen and Lee, \{Jong Young\} and Johnson, \{Todd A.\} and Huaixing Li and Xiaobo Yang and Juncheng Dai and Liming Liang and Lixuan Gui and Qibin Qi and Jinyan Huang and Yanping Li and Adair, \{Linda S.\} and Tin Aung and Qiuyin Cai and Cheng, \{Ching Yu\} and Cho, \{Myeong Chan\} and Cho, \{Yoon Shin\} and Minjie Chu and Bin Cui and Gao, \{Yu Tang\} and Go, \{Min Jin\} and Dongfeng Gu and Weiqiong Gu and Huan Guo and Yongchen Hao and Jie Hong and Zhibin Hu and Yanling Hu and Jianfeng Huang and Hwang, \{Joo Yeon\} and Ikram, \{Mohammad Kamran\} and Guangfu Jin and Kang, \{Dae Hee\} and Khor, \{Chiea Chuen\} and Kim, \{Bong Jo\} and Kim, \{Hung Tae\} and Michiaki Kubo and Jeannette Lee and Juyoung Lee and Lee, \{Nanette R.\} and Ruoying Li and Jun Li and Liu, \{Jian Jun\} and Jirong Longe and Wei Lu and Xiangfeng Lu and Xiaoping Miao and Yukinori Okada and Ong, \{Rick Twee Hee\} and Gaokun Qiu and Mark Seielstad and Xueling Sim and Huaidong Song and Fumihiko Takeuchi and Toshihiro Tanaka and Taylor, \{Phil R.\} and Laiyuan Wang and Weiqing Wang and Yiqin Wang and Chen Wu and Ying Wu and Xiang, \{Yong Bing\} and Ken Yamamoto and Handong Yang and Ming Liao and Mitsuhiro Yokota and Terri Young and Xiaomin Zhang and Norihiro Kato and Wang, \{Qing K.\} and Wei Zheng and Hu, \{Frank B.\} and Dongxin Lin and Hongbing Shen and Teo, \{Yik Ying\} and Zengnan Mo and Wong, \{Tien Yin\} and Xu Lin and Mohlke, \{Karen L.\} and Guang Ning and Tatsuhiko Tsunoda and Han, \{Bok Ghee\} and Shu, \{Xiao Ou\} and Tai, \{E. Shyong\} and Tangchun Wu and Lu Qi",

year = "2015",

month = mar,

day = "15",

doi = "10.1093/hmg/ddu583",

language = "英語",

volume = "24",

pages = "1791--1800",

journal = "Human Molecular Genetics",

issn = "0964-6906",

publisher = "Oxford University Press",

number = "6",

}

He, M, Xu, M, Zhang, B, Liang, J, Chen, P, Lee, JY, Johnson, TA, Li, H, Yang, X, Dai, J, Liang, L, Gui, L, Qi, Q, Huang, J, Li, Y, Adair, LS, Aung, T, Cai, Q, Cheng, CY, Cho, MC, Cho, YS, Chu, M, Cui, B, Gao, YT, Go, MJ, Gu, D, Gu, W, Guo, H, Hao, Y, Hong, J, Hu, Z, Hu, Y, Huang, J, Hwang, JY, Ikram, MK, Jin, G, Kang, DH, Khor, CC, Kim, BJ, Kim, HT, Kubo, M, Lee, J, Lee, J, Lee, NR, Li, R, Li, J, Liu, JJ, Longe, J, Lu, W, Lu, X, Miao, X, Okada, Y, Ong, RTH, Qiu, G, Seielstad, M, Sim, X, Song, H, Takeuchi, F, Tanaka, T, Taylor, PR, Wang, L, Wang, W, Wang, Y, Wu, C, Wu, Y, Xiang, YB, Yamamoto, K, Yang, H, Liao, M, Yokota, M, Young, T, Zhang, X, Kato, N, Wang, QK, Zheng, W, Hu, FB, Lin, D, Shen, H, Teo, YY, Mo, Z, Wong, TY, Lin, X, Mohlke, KL, Ning, G, Tsunoda, T, Han, BG, Shu, XO, Tai, ES, Wu, T & Qi, L 2015, 'Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci', Human Molecular Genetics, vol. 24, no. 6, pp. 1791-1800. https://doi.org/10.1093/hmg/ddu583

TY - JOUR

T1 - Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci

AU - He, Meian

AU - Xu, Min

AU - Zhang, Ben

AU - Liang, Jun

AU - Chen, Peng

AU - Lee, Jong Young

AU - Johnson, Todd A.

AU - Li, Huaixing

AU - Yang, Xiaobo

AU - Dai, Juncheng

AU - Liang, Liming

AU - Gui, Lixuan

AU - Qi, Qibin

AU - Huang, Jinyan

AU - Li, Yanping

AU - Adair, Linda S.

AU - Aung, Tin

AU - Cai, Qiuyin

AU - Cheng, Ching Yu

AU - Cho, Myeong Chan

AU - Cho, Yoon Shin

AU - Chu, Minjie

AU - Cui, Bin

AU - Gao, Yu Tang

AU - Go, Min Jin

AU - Gu, Dongfeng

AU - Gu, Weiqiong

AU - Guo, Huan

AU - Hao, Yongchen

AU - Hong, Jie

AU - Hu, Zhibin

AU - Hu, Yanling

AU - Huang, Jianfeng

AU - Hwang, Joo Yeon

AU - Ikram, Mohammad Kamran

AU - Jin, Guangfu

AU - Kang, Dae Hee

AU - Khor, Chiea Chuen

AU - Kim, Bong Jo

AU - Kim, Hung Tae

AU - Kubo, Michiaki

AU - Lee, Jeannette

AU - Lee, Juyoung

AU - Lee, Nanette R.

AU - Li, Ruoying

AU - Li, Jun

AU - Liu, Jian Jun

AU - Longe, Jirong

AU - Lu, Wei

AU - Lu, Xiangfeng

AU - Miao, Xiaoping

AU - Okada, Yukinori

AU - Ong, Rick Twee Hee

AU - Qiu, Gaokun

AU - Seielstad, Mark

AU - Sim, Xueling

AU - Song, Huaidong

AU - Takeuchi, Fumihiko

AU - Tanaka, Toshihiro

AU - Taylor, Phil R.

AU - Wang, Laiyuan

AU - Wang, Weiqing

AU - Wang, Yiqin

AU - Wu, Chen

AU - Wu, Ying

AU - Xiang, Yong Bing

AU - Yamamoto, Ken

AU - Yang, Handong

AU - Liao, Ming

AU - Yokota, Mitsuhiro

AU - Young, Terri

AU - Zhang, Xiaomin

AU - Kato, Norihiro

AU - Wang, Qing K.

AU - Zheng, Wei

AU - Hu, Frank B.

AU - Lin, Dongxin

AU - Shen, Hongbing

AU - Teo, Yik Ying

AU - Mo, Zengnan

AU - Wong, Tien Yin

AU - Lin, Xu

AU - Mohlke, Karen L.

AU - Ning, Guang

AU - Tsunoda, Tatsuhiko

AU - Han, Bok Ghee

AU - Shu, Xiao Ou

AU - Tai, E. Shyong

AU - Wu, Tangchun

AU - Qi, Lu

PY - 2015/3/15

Y1 - 2015/3/15

N2 - Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A recent study showed high replicability of results from Europeans-based GWA studies in Asians; however, population-specific loci may exist due to distinct linkage disequilibrium patterns. We carried out a GWA meta-analysis in 93 926 individuals from East Asia. We identified 98 loci, including 17 novel and 81 previously reported loci, associated with height at P < 5 × 10-8, together explaining 8.89% of phenotypic variance. Among the newly identified variants, 10 are commonly distributed (minor allele frequency, MAF > 5%) in Europeans, with comparable frequencies with in Asians, and 7 single-nucleotide polymorphisms are with low frequency (MAF < 5%) in Europeans. In addition, our data suggest that novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of height. The findings from this study considerably expand our knowledge of the genetic architecture of human height in Asians.

AB - Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A recent study showed high replicability of results from Europeans-based GWA studies in Asians; however, population-specific loci may exist due to distinct linkage disequilibrium patterns. We carried out a GWA meta-analysis in 93 926 individuals from East Asia. We identified 98 loci, including 17 novel and 81 previously reported loci, associated with height at P < 5 × 10-8, together explaining 8.89% of phenotypic variance. Among the newly identified variants, 10 are commonly distributed (minor allele frequency, MAF > 5%) in Europeans, with comparable frequencies with in Asians, and 7 single-nucleotide polymorphisms are with low frequency (MAF < 5%) in Europeans. In addition, our data suggest that novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of height. The findings from this study considerably expand our knowledge of the genetic architecture of human height in Asians.

UR - https://www.scopus.com/pages/publications/84936073085

U2 - 10.1093/hmg/ddu583

DO - 10.1093/hmg/ddu583

M3 - 記事

C2 - 25429064

AN - SCOPUS:84936073085

SN - 0964-6906

VL - 24

SP - 1791

EP - 1800

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 6

ER -

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci

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