Lumbar vertebral bone mineral density in Japanese infants and children: Measurement with dual x-ray absorptiometry

Dual x-ray absorptiometry (DXA) (Hologic QDR-1000/W; Hologic, Inc.) was used to measure lumbar vertebral bone mineral density (BMD) in 83 healthy Japanese infants and children (55 boys and 28 girls) aged 0-17 years, and the values obtained were correlated with age, body weight and body height. The lumbar BMD (average of L1-L4 values) increased with age, with a nearly twofold increase found from preschool age to adolescence. It also increased with body weight and body height. Our results on normal Japanese infants and children appear almost similar to those reported in French and American studies. Because of its great precision and accuracy, low radiation exposure and rapid scanning, DXA may be the most suitable for use in infants and children. With normal Japanese data now available with this technique, pediatricians can better detect metabolic bone diseases in infants and children and follow the bone response to medical intervention in patients with these conditions.