Lipase-catalyzed transesterification of methyl 2-substituted 3-hydroxy-4-pentenoates and its synthetic application to the taxol side chain

Tadakatsu Mandai; Tetsuta Oshitari; Masafumi Susowake

doi:10.1055/s-2002-34247

Lipase-catalyzed transesterification of methyl 2-substituted 3-hydroxy-4-pentenoates and its synthetic application to the taxol side chain

Tadakatsu Mandai, Tetsuta Oshitari, Masafumi Susowake

Kurashiki University of Science and the Arts

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Syn-and anti-methyl 2-substituted 3-hydroxy-4-pentenoates were efficiently resolved in lipase-catalyzed transesterification. This protocol was successfully applied to the synthesis of the taxol side chain.

Original language	English
Pages (from-to)	1665-1668
Number of pages	4
Journal	Synlett
Issue number	10
DOIs	https://doi.org/10.1055/s-2002-34247
State	Published - 2002
Externally published	Yes

Keywords

1,2-amino alcohols
Lipase-catalyzed kinetic resolution
Syn- and anti-methyl 2-substituted 3-hydroxy-4-pentenoates
The taxol side chain

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10.1055/s-2002-34247

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title = "Lipase-catalyzed transesterification of methyl 2-substituted 3-hydroxy-4-pentenoates and its synthetic application to the taxol side chain",

abstract = "Syn-and anti-methyl 2-substituted 3-hydroxy-4-pentenoates were efficiently resolved in lipase-catalyzed transesterification. This protocol was successfully applied to the synthesis of the taxol side chain.",

keywords = "1,2-amino alcohols, Lipase-catalyzed kinetic resolution, Syn- and anti-methyl 2-substituted 3-hydroxy-4-pentenoates, The taxol side chain",

author = "Tadakatsu Mandai and Tetsuta Oshitari and Masafumi Susowake",

year = "2002",

doi = "10.1055/s-2002-34247",

language = "英語",

pages = "1665--1668",

journal = "Synlett",

issn = "0936-5214",

publisher = "Georg Thieme Verlag",

number = "10",

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T1 - Lipase-catalyzed transesterification of methyl 2-substituted 3-hydroxy-4-pentenoates and its synthetic application to the taxol side chain

AU - Mandai, Tadakatsu

AU - Oshitari, Tetsuta

AU - Susowake, Masafumi

PY - 2002

Y1 - 2002

N2 - Syn-and anti-methyl 2-substituted 3-hydroxy-4-pentenoates were efficiently resolved in lipase-catalyzed transesterification. This protocol was successfully applied to the synthesis of the taxol side chain.

AB - Syn-and anti-methyl 2-substituted 3-hydroxy-4-pentenoates were efficiently resolved in lipase-catalyzed transesterification. This protocol was successfully applied to the synthesis of the taxol side chain.

KW - 1,2-amino alcohols

KW - Lipase-catalyzed kinetic resolution

KW - Syn- and anti-methyl 2-substituted 3-hydroxy-4-pentenoates

KW - The taxol side chain

UR - https://www.scopus.com/pages/publications/0036403288

U2 - 10.1055/s-2002-34247

DO - 10.1055/s-2002-34247

M3 - 記事

AN - SCOPUS:0036403288

SN - 0936-5214

SP - 1665

EP - 1668

JO - Synlett

JF - Synlett

IS - 10

ER -

Lipase-catalyzed transesterification of methyl 2-substituted 3-hydroxy-4-pentenoates and its synthetic application to the taxol side chain

Abstract

Keywords

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