Interaction of peptides derived from RecA with single-stranded oligonucleotides containing 5-formyl-2'-deoxyuridine.

T. Sugiyama; A. Kittaka; H. Takayama; M. Tomioka; Y. Ida; R. Kuroda

doi:10.1093/nass/44.1.41

Interaction of peptides derived from RecA with single-stranded oligonucleotides containing 5-formyl-2'-deoxyuridine.

T. Sugiyama
, A. Kittaka
, H. Takayama
, M. Tomioka
, Y. Ida
, R. Kuroda

The University of Tokyo

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We report the first example of chemical cross-linking of 5-formyl-2'-deoxyuridine containing oligonucleotides with oligopeptides through a Schiff base formation. Twenty amino acid residue peptides investigated here were derived from the DNA binding site of RecA protein. We have demonstrated that the lysine residue placed at the 6th or 8th position from the N-terminus of the peptide directly contacts with DNA.

Original language	English
Pages (from-to)	41-42
Number of pages	2
Journal	Nucleic acids symposium series
Issue number	44
DOIs	https://doi.org/10.1093/nass/44.1.41
State	Published - 2000
Externally published	Yes

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10.1093/nass/44.1.41

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title = "Interaction of peptides derived from RecA with single-stranded oligonucleotides containing 5-formyl-2'-deoxyuridine.",

abstract = "We report the first example of chemical cross-linking of 5-formyl-2'-deoxyuridine containing oligonucleotides with oligopeptides through a Schiff base formation. Twenty amino acid residue peptides investigated here were derived from the DNA binding site of RecA protein. We have demonstrated that the lysine residue placed at the 6th or 8th position from the N-terminus of the peptide directly contacts with DNA.",

author = "T. Sugiyama and A. Kittaka and H. Takayama and M. Tomioka and Y. Ida and R. Kuroda",

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T1 - Interaction of peptides derived from RecA with single-stranded oligonucleotides containing 5-formyl-2'-deoxyuridine.

AU - Sugiyama, T.

AU - Kittaka, A.

AU - Takayama, H.

AU - Tomioka, M.

AU - Ida, Y.

AU - Kuroda, R.

PY - 2000

Y1 - 2000

N2 - We report the first example of chemical cross-linking of 5-formyl-2'-deoxyuridine containing oligonucleotides with oligopeptides through a Schiff base formation. Twenty amino acid residue peptides investigated here were derived from the DNA binding site of RecA protein. We have demonstrated that the lysine residue placed at the 6th or 8th position from the N-terminus of the peptide directly contacts with DNA.

AB - We report the first example of chemical cross-linking of 5-formyl-2'-deoxyuridine containing oligonucleotides with oligopeptides through a Schiff base formation. Twenty amino acid residue peptides investigated here were derived from the DNA binding site of RecA protein. We have demonstrated that the lysine residue placed at the 6th or 8th position from the N-terminus of the peptide directly contacts with DNA.

UR - https://www.scopus.com/pages/publications/0141782247

U2 - 10.1093/nass/44.1.41

DO - 10.1093/nass/44.1.41

M3 - 記事

C2 - 12903258

AN - SCOPUS:0141782247

SN - 0261-3166

SP - 41

EP - 42

JO - Nucleic acids symposium series

JF - Nucleic acids symposium series

IS - 44

ER -

Interaction of peptides derived from RecA with single-stranded oligonucleotides containing 5-formyl-2'-deoxyuridine.

Abstract

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