Inhibition by 2-arachidonoylglycerol, a novel type of possible neuromodulator, of the depolarization-induced increase in intracellular free calcium in neuroblastoma x glioma hybrid NG108-15 cells

Takayuki Sugiura; Tomoko Kodaka; Sachiko Kondo; Takashi Tonegawa; Shinji Nakane; Seishi Kishimoto; Atsushi Yamashita; Keizo Waku

doi:10.1006/bbrc.1997.6425

Inhibition by 2-arachidonoylglycerol, a novel type of possible neuromodulator, of the depolarization-induced increase in intracellular free calcium in neuroblastoma x glioma hybrid NG108-15 cells

Takayuki Sugiura, Tomoko Kodaka, Sachiko Kondo, Takashi Tonegawa, Shinji Nakane, Seishi Kishimoto, Atsushi Yamashita, Keizo Waku

Faculty of Pharmaceutical Sciences

Teikyo University

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

2-Arachidonoylglycerol was found to inhibit the depolarization-induced increase in [Ca²⁺](i) in NG108-15 cells differentiated with prostaglandin E₁ and theophylline in a dose-dependent manner. Such an effect appears to be rather specific to polyunsaturated fatty acid-containing monoacylglycerols such as 2-arachidonoylglycerol. Neither 2-palmitoylglycerol nor free arachidonic acid exhibited appreciable inhibitory activity. These observations raise the possibility that 2-arachidonoylglycerol attenuates the increase in [Ca²⁺](i), thereby modulating several neural functions in this type of cell.

Original language	English
Pages (from-to)	207-210
Number of pages	4
Journal	Biochemical and Biophysical Research Communications
Volume	233
Issue number	1
DOIs	https://doi.org/10.1006/bbrc.1997.6425
State	Published - 7 Apr 1997

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Sugiura, T., Kodaka, T., Kondo, S., Tonegawa, T., Nakane, S., Kishimoto, S., Yamashita, A., & Waku, K. (1997). Inhibition by 2-arachidonoylglycerol, a novel type of possible neuromodulator, of the depolarization-induced increase in intracellular free calcium in neuroblastoma x glioma hybrid NG108-15 cells. Biochemical and Biophysical Research Communications, 233(1), 207-210. https://doi.org/10.1006/bbrc.1997.6425

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title = "Inhibition by 2-arachidonoylglycerol, a novel type of possible neuromodulator, of the depolarization-induced increase in intracellular free calcium in neuroblastoma x glioma hybrid NG108-15 cells",

abstract = "2-Arachidonoylglycerol was found to inhibit the depolarization-induced increase in [Ca2+](i) in NG108-15 cells differentiated with prostaglandin E1 and theophylline in a dose-dependent manner. Such an effect appears to be rather specific to polyunsaturated fatty acid-containing monoacylglycerols such as 2-arachidonoylglycerol. Neither 2-palmitoylglycerol nor free arachidonic acid exhibited appreciable inhibitory activity. These observations raise the possibility that 2-arachidonoylglycerol attenuates the increase in [Ca2+](i), thereby modulating several neural functions in this type of cell.",

author = "Takayuki Sugiura and Tomoko Kodaka and Sachiko Kondo and Takashi Tonegawa and Shinji Nakane and Seishi Kishimoto and Atsushi Yamashita and Keizo Waku",

year = "1997",

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doi = "10.1006/bbrc.1997.6425",

language = "英語",

volume = "233",

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Sugiura, T, Kodaka, T, Kondo, S, Tonegawa, T, Nakane, S, Kishimoto, S, Yamashita, A & Waku, K 1997, 'Inhibition by 2-arachidonoylglycerol, a novel type of possible neuromodulator, of the depolarization-induced increase in intracellular free calcium in neuroblastoma x glioma hybrid NG108-15 cells', Biochemical and Biophysical Research Communications, vol. 233, no. 1, pp. 207-210. https://doi.org/10.1006/bbrc.1997.6425

Inhibition by 2-arachidonoylglycerol, a novel type of possible neuromodulator, of the depolarization-induced increase in intracellular free calcium in neuroblastoma x glioma hybrid NG108-15 cells. / Sugiura, Takayuki; Kodaka, Tomoko; Kondo, Sachiko et al.
In: Biochemical and Biophysical Research Communications, Vol. 233, No. 1, 07.04.1997, p. 207-210.

Research output: Contribution to journal › Article › peer-review

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T1 - Inhibition by 2-arachidonoylglycerol, a novel type of possible neuromodulator, of the depolarization-induced increase in intracellular free calcium in neuroblastoma x glioma hybrid NG108-15 cells

AU - Sugiura, Takayuki

AU - Kodaka, Tomoko

AU - Kondo, Sachiko

AU - Tonegawa, Takashi

AU - Nakane, Shinji

AU - Kishimoto, Seishi

AU - Yamashita, Atsushi

AU - Waku, Keizo

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N2 - 2-Arachidonoylglycerol was found to inhibit the depolarization-induced increase in [Ca2+](i) in NG108-15 cells differentiated with prostaglandin E1 and theophylline in a dose-dependent manner. Such an effect appears to be rather specific to polyunsaturated fatty acid-containing monoacylglycerols such as 2-arachidonoylglycerol. Neither 2-palmitoylglycerol nor free arachidonic acid exhibited appreciable inhibitory activity. These observations raise the possibility that 2-arachidonoylglycerol attenuates the increase in [Ca2+](i), thereby modulating several neural functions in this type of cell.

AB - 2-Arachidonoylglycerol was found to inhibit the depolarization-induced increase in [Ca2+](i) in NG108-15 cells differentiated with prostaglandin E1 and theophylline in a dose-dependent manner. Such an effect appears to be rather specific to polyunsaturated fatty acid-containing monoacylglycerols such as 2-arachidonoylglycerol. Neither 2-palmitoylglycerol nor free arachidonic acid exhibited appreciable inhibitory activity. These observations raise the possibility that 2-arachidonoylglycerol attenuates the increase in [Ca2+](i), thereby modulating several neural functions in this type of cell.

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Sugiura T, Kodaka T, Kondo S, Tonegawa T, Nakane S, Kishimoto S et al. Inhibition by 2-arachidonoylglycerol, a novel type of possible neuromodulator, of the depolarization-induced increase in intracellular free calcium in neuroblastoma x glioma hybrid NG108-15 cells. Biochemical and Biophysical Research Communications. 1997 Apr 7;233(1):207-210. doi: 10.1006/bbrc.1997.6425

Inhibition by 2-arachidonoylglycerol, a novel type of possible neuromodulator, of the depolarization-induced increase in intracellular free calcium in neuroblastoma x glioma hybrid NG108-15 cells

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