Induction of subcutaneous tumors in rats by 3,7- and 3,9- dinitrofluoranthene

Hiroshi Tokiwa; Takeshi Otofuji; Kazumi Horikawa; Nobuyuki Sera; Reiko Nakagawa; Toshiharu Maeda; Nobuya Sano; Keisuke Izumi; Hisashi Otsuka

doi:10.1093/carcin/8.12.1919

Induction of subcutaneous tumors in rats by 3,7- and 3,9- dinitrofluoranthene

Hiroshi Tokiwa
, Takeshi Otofuji
, Kazumi Horikawa
, Nobuyuki Sera
, Reiko Nakagawa
, Toshiharu Maeda
, Nobuya Sano
, Keisuke Izumi
, Hisashi Otsuka

Fukuoka Environmental Research Centre
Tokushima University

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Two dinitrofluoranthenes (DNFs) derived from 3-nitrofluoranthene were purified to over 99%, and tested for tumorigenicity in F344/DuCrj male rats. Rats were inoculated s.c. with 0.05 mg 3,7- or 3,9-DNF twice a week for 10 weeks. All 21 rats given 3,7-DNF and 10 of 11 rats (91%) given 3,9-DNF developed tumors at the injection site by 48 weeks after the first injection. Twenty of the 21 tumors induced by 3,7-DNF and seven of the 10 tumors induced by 3,9-DNF were classified as malignant fibrous histiocytoma, but one tumor in the 3,7-DNF-treated group and three tumors induced by 3,9-DNF showed typical features of rhabdomyosarcoma. The first tumors in 3,9-DNF-treated rats appeared on day 88 (on day average 117), 10 weeks earlier than in 3,7-DNF-treated ones (on day average 186).

Original language	English
Pages (from-to)	1919-1922
Number of pages	4
Journal	Carcinogenesis
Volume	8
Issue number	12
DOIs	https://doi.org/10.1093/carcin/8.12.1919
State	Published - Dec 1987
Externally published	Yes

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@article{49ec7093f4fe4fa58ca5b49b1b6a6d4e,

title = "Induction of subcutaneous tumors in rats by 3,7- and 3,9- dinitrofluoranthene",

abstract = "Two dinitrofluoranthenes (DNFs) derived from 3-nitrofluoranthene were purified to over 99\%, and tested for tumorigenicity in F344/DuCrj male rats. Rats were inoculated s.c. with 0.05 mg 3,7- or 3,9-DNF twice a week for 10 weeks. All 21 rats given 3,7-DNF and 10 of 11 rats (91\%) given 3,9-DNF developed tumors at the injection site by 48 weeks after the first injection. Twenty of the 21 tumors induced by 3,7-DNF and seven of the 10 tumors induced by 3,9-DNF were classified as malignant fibrous histiocytoma, but one tumor in the 3,7-DNF-treated group and three tumors induced by 3,9-DNF showed typical features of rhabdomyosarcoma. The first tumors in 3,9-DNF-treated rats appeared on day 88 (on day average 117), 10 weeks earlier than in 3,7-DNF-treated ones (on day average 186).",

author = "Hiroshi Tokiwa and Takeshi Otofuji and Kazumi Horikawa and Nobuyuki Sera and Reiko Nakagawa and Toshiharu Maeda and Nobuya Sano and Keisuke Izumi and Hisashi Otsuka",

year = "1987",

month = dec,

doi = "10.1093/carcin/8.12.1919",

language = "英語",

volume = "8",

pages = "1919--1922",

journal = "Carcinogenesis",

issn = "0143-3334",

publisher = "Oxford University Press",

number = "12",

}

TY - JOUR

T1 - Induction of subcutaneous tumors in rats by 3,7- and 3,9- dinitrofluoranthene

AU - Tokiwa, Hiroshi

AU - Otofuji, Takeshi

AU - Horikawa, Kazumi

AU - Sera, Nobuyuki

AU - Nakagawa, Reiko

AU - Maeda, Toshiharu

AU - Sano, Nobuya

AU - Izumi, Keisuke

AU - Otsuka, Hisashi

PY - 1987/12

Y1 - 1987/12

N2 - Two dinitrofluoranthenes (DNFs) derived from 3-nitrofluoranthene were purified to over 99%, and tested for tumorigenicity in F344/DuCrj male rats. Rats were inoculated s.c. with 0.05 mg 3,7- or 3,9-DNF twice a week for 10 weeks. All 21 rats given 3,7-DNF and 10 of 11 rats (91%) given 3,9-DNF developed tumors at the injection site by 48 weeks after the first injection. Twenty of the 21 tumors induced by 3,7-DNF and seven of the 10 tumors induced by 3,9-DNF were classified as malignant fibrous histiocytoma, but one tumor in the 3,7-DNF-treated group and three tumors induced by 3,9-DNF showed typical features of rhabdomyosarcoma. The first tumors in 3,9-DNF-treated rats appeared on day 88 (on day average 117), 10 weeks earlier than in 3,7-DNF-treated ones (on day average 186).

AB - Two dinitrofluoranthenes (DNFs) derived from 3-nitrofluoranthene were purified to over 99%, and tested for tumorigenicity in F344/DuCrj male rats. Rats were inoculated s.c. with 0.05 mg 3,7- or 3,9-DNF twice a week for 10 weeks. All 21 rats given 3,7-DNF and 10 of 11 rats (91%) given 3,9-DNF developed tumors at the injection site by 48 weeks after the first injection. Twenty of the 21 tumors induced by 3,7-DNF and seven of the 10 tumors induced by 3,9-DNF were classified as malignant fibrous histiocytoma, but one tumor in the 3,7-DNF-treated group and three tumors induced by 3,9-DNF showed typical features of rhabdomyosarcoma. The first tumors in 3,9-DNF-treated rats appeared on day 88 (on day average 117), 10 weeks earlier than in 3,7-DNF-treated ones (on day average 186).

UR - https://www.scopus.com/pages/publications/0023628855

U2 - 10.1093/carcin/8.12.1919

DO - 10.1093/carcin/8.12.1919

M3 - 記事

C2 - 2824085

AN - SCOPUS:0023628855

SN - 0143-3334

VL - 8

SP - 1919

EP - 1922

JO - Carcinogenesis

JF - Carcinogenesis

IS - 12

ER -

Induction of subcutaneous tumors in rats by 3,7- and 3,9- dinitrofluoranthene

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