TY - JOUR
T1 - In vivo drug dissolution in human oral cavity from orally disintegrating tablet and comparability with in vitro testing
AU - Katayama, Tsuyoshi
AU - Uchida, Shinya
AU - Kamiya, Chiaki
AU - Tanaka, Shimako
AU - Kashiwagura, Yasuharu
AU - Hakamata, Akio
AU - Odagiri, Keiichi
AU - Inui, Naoki
AU - Watanabe, Hiroshi
AU - Namiki, Noriyuki
N1 - Publisher Copyright:
© 2018 The Pharmaceutical Society of Japan.
PY - 2018
Y1 - 2018
N2 - We examined the amlodipine dissolution from orally disintegrating tablets (ODTs) in vivo in the human oral cavity. Additionally, 5 different in vitro short dissolution test methods (Tricorptester, magnetic stirrer, rotating injection syringe, paddle apparatus, shaking) were used to evaluate dissolution and the results were compared to those obtained with the human volunteers. Various amlodipine ODTs with different levels of physical masking effectiveness were manufactured using the RACTAB® technique. Quantitative findings showed that amlodipine dissolution from ODT was dependent on time in the oral cavity and the amount of coating applied for physical masking. We also found that dissolution in the oral cavity was best correlated to that in in vitro short dissolution tests with a time period of 30 s. For more detailed evaluations, mean prediction error, mean absolute error, and root mean square error values were calculated, each of which was lowest with the Tricorptester method among all of the investigated test methods. Our results indicate that mimicking of the inside of the human oral cavity is accurate with a testing time of 30 s, while the Tricorptester method was the most preferable of all in vitro tests investigated in this study.
AB - We examined the amlodipine dissolution from orally disintegrating tablets (ODTs) in vivo in the human oral cavity. Additionally, 5 different in vitro short dissolution test methods (Tricorptester, magnetic stirrer, rotating injection syringe, paddle apparatus, shaking) were used to evaluate dissolution and the results were compared to those obtained with the human volunteers. Various amlodipine ODTs with different levels of physical masking effectiveness were manufactured using the RACTAB® technique. Quantitative findings showed that amlodipine dissolution from ODT was dependent on time in the oral cavity and the amount of coating applied for physical masking. We also found that dissolution in the oral cavity was best correlated to that in in vitro short dissolution tests with a time period of 30 s. For more detailed evaluations, mean prediction error, mean absolute error, and root mean square error values were calculated, each of which was lowest with the Tricorptester method among all of the investigated test methods. Our results indicate that mimicking of the inside of the human oral cavity is accurate with a testing time of 30 s, while the Tricorptester method was the most preferable of all in vitro tests investigated in this study.
KW - amlodipine
KW - bitterness masking
KW - dissolution
KW - in vitro short dissolution test
KW - oral cavity
KW - orally disintegrating tablet
UR - http://www.scopus.com/inward/record.url?scp=85054133489&partnerID=8YFLogxK
U2 - 10.1248/cpb.c18-00492
DO - 10.1248/cpb.c18-00492
M3 - 記事
C2 - 30270246
AN - SCOPUS:85054133489
SN - 0009-2363
VL - 66
SP - 999
EP - 1005
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
IS - 10
ER -