In vivo drug dissolution in human oral cavity from orally disintegrating tablet and comparability with in vitro testing

Tsuyoshi Katayama, Shinya Uchida, Chiaki Kamiya, Shimako Tanaka, Yasuharu Kashiwagura, Akio Hakamata, Keiichi Odagiri, Naoki Inui, Hiroshi Watanabe, Noriyuki Namiki

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

We examined the amlodipine dissolution from orally disintegrating tablets (ODTs) in vivo in the human oral cavity. Additionally, 5 different in vitro short dissolution test methods (Tricorptester, magnetic stirrer, rotating injection syringe, paddle apparatus, shaking) were used to evaluate dissolution and the results were compared to those obtained with the human volunteers. Various amlodipine ODTs with different levels of physical masking effectiveness were manufactured using the RACTAB® technique. Quantitative findings showed that amlodipine dissolution from ODT was dependent on time in the oral cavity and the amount of coating applied for physical masking. We also found that dissolution in the oral cavity was best correlated to that in in vitro short dissolution tests with a time period of 30 s. For more detailed evaluations, mean prediction error, mean absolute error, and root mean square error values were calculated, each of which was lowest with the Tricorptester method among all of the investigated test methods. Our results indicate that mimicking of the inside of the human oral cavity is accurate with a testing time of 30 s, while the Tricorptester method was the most preferable of all in vitro tests investigated in this study.

Original languageEnglish
Pages (from-to)999-1005
Number of pages7
JournalChemical and Pharmaceutical Bulletin
Volume66
Issue number10
DOIs
StatePublished - 2018
Externally publishedYes

Keywords

  • amlodipine
  • bitterness masking
  • dissolution
  • in vitro short dissolution test
  • oral cavity
  • orally disintegrating tablet

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