In vitro Azole Susceptibility Testing of Japanese Isolates of Terbinafine-Resistant Trichophyton indotineae and Trichophyton rubrum

Junichiro Hiruma; Utako Kimura; Hiromitsu Noguchi; Masataro Hiruma; Kazutoshi Harada; Rui Kano

doi:10.3314/mmj.22-00021

In vitro Azole Susceptibility Testing of Japanese Isolates of Terbinafine-Resistant Trichophyton indotineae and Trichophyton rubrum

Junichiro Hiruma
, Utako Kimura
, Hiromitsu Noguchi
, Masataro Hiruma
, Kazutoshi Harada
, Rui Kano

Teikyo University Institute of Medical Mycology

Tokyo Medical University
Teikyo University
Juntendo University
Noguchi Dermatology Clinic
Ochanomizu Institute for Medical Mycology and Allergology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Multi-antifungal-resistant strains of Trichophyton indotineae and Trichophyton rubrum have been isolated in Japan. In the present study, we examined the in vitro susceptibility of terbinafine (TRBF)-resistant isolates of T. indotineae and T. rubrum to efinaconazole (EFCZ) and luliconazole (LUCZ). In all isolates, the minimum inhibitory concentrations were ≥ 32 mg/l for TRBF, < 0.03 to 16 mg/l for itraconazole, < 0.03 to 16 mg/l for ravuconazole, < 0.03 to 0.5 mg/l for LUCZ, and < 0.03 to 4 mg/l for EFCZ. Of note, T. rubrum NUBS21012 and T. indotineae NUBS 19006^T showed resistance to LUCZ and/or EFCZ unlike the other isolates.

Original language	English
Pages (from-to)	23-25
Number of pages	3
Journal	Medical Mycology Journal
Volume	64
Issue number	1
DOIs	https://doi.org/10.3314/mmj.22-00021
State	Published - 2023

Keywords

Trichophyton indotineae
Trichophyton rubrum
resistance
susceptibility test

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10.3314/mmj.22-00021

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@article{aec365a798e5463d85dacc78522053a8,

title = "In vitro Azole Susceptibility Testing of Japanese Isolates of Terbinafine-Resistant Trichophyton indotineae and Trichophyton rubrum",

abstract = "Multi-antifungal-resistant strains of Trichophyton indotineae and Trichophyton rubrum have been isolated in Japan. In the present study, we examined the in vitro susceptibility of terbinafine (TRBF)-resistant isolates of T. indotineae and T. rubrum to efinaconazole (EFCZ) and luliconazole (LUCZ). In all isolates, the minimum inhibitory concentrations were ≥ 32 mg/l for TRBF, < 0.03 to 16 mg/l for itraconazole, < 0.03 to 16 mg/l for ravuconazole, < 0.03 to 0.5 mg/l for LUCZ, and < 0.03 to 4 mg/l for EFCZ. Of note, T. rubrum NUBS21012 and T. indotineae NUBS 19006T showed resistance to LUCZ and/or EFCZ unlike the other isolates.",

keywords = "Trichophyton indotineae, Trichophyton rubrum, resistance, susceptibility test",

author = "Junichiro Hiruma and Utako Kimura and Hiromitsu Noguchi and Masataro Hiruma and Kazutoshi Harada and Rui Kano",

year = "2023",

doi = "10.3314/mmj.22-00021",

language = "英語",

volume = "64",

pages = "23--25",

journal = "Medical Mycology Journal",

issn = "2185-6486",

publisher = "Japanese Society for Medical Mycology",

number = "1",

}

TY - JOUR

T1 - In vitro Azole Susceptibility Testing of Japanese Isolates of Terbinafine-Resistant Trichophyton indotineae and Trichophyton rubrum

AU - Hiruma, Junichiro

AU - Kimura, Utako

AU - Noguchi, Hiromitsu

AU - Hiruma, Masataro

AU - Harada, Kazutoshi

AU - Kano, Rui

PY - 2023

Y1 - 2023

N2 - Multi-antifungal-resistant strains of Trichophyton indotineae and Trichophyton rubrum have been isolated in Japan. In the present study, we examined the in vitro susceptibility of terbinafine (TRBF)-resistant isolates of T. indotineae and T. rubrum to efinaconazole (EFCZ) and luliconazole (LUCZ). In all isolates, the minimum inhibitory concentrations were ≥ 32 mg/l for TRBF, < 0.03 to 16 mg/l for itraconazole, < 0.03 to 16 mg/l for ravuconazole, < 0.03 to 0.5 mg/l for LUCZ, and < 0.03 to 4 mg/l for EFCZ. Of note, T. rubrum NUBS21012 and T. indotineae NUBS 19006T showed resistance to LUCZ and/or EFCZ unlike the other isolates.

AB - Multi-antifungal-resistant strains of Trichophyton indotineae and Trichophyton rubrum have been isolated in Japan. In the present study, we examined the in vitro susceptibility of terbinafine (TRBF)-resistant isolates of T. indotineae and T. rubrum to efinaconazole (EFCZ) and luliconazole (LUCZ). In all isolates, the minimum inhibitory concentrations were ≥ 32 mg/l for TRBF, < 0.03 to 16 mg/l for itraconazole, < 0.03 to 16 mg/l for ravuconazole, < 0.03 to 0.5 mg/l for LUCZ, and < 0.03 to 4 mg/l for EFCZ. Of note, T. rubrum NUBS21012 and T. indotineae NUBS 19006T showed resistance to LUCZ and/or EFCZ unlike the other isolates.

KW - Trichophyton indotineae

KW - Trichophyton rubrum

KW - resistance

KW - susceptibility test

UR - https://www.scopus.com/pages/publications/85149217733

U2 - 10.3314/mmj.22-00021

DO - 10.3314/mmj.22-00021

M3 - 記事

C2 - 36858630

AN - SCOPUS:85149217733

SN - 2185-6486

VL - 64

SP - 23

EP - 25

JO - Medical Mycology Journal

JF - Medical Mycology Journal

IS - 1

ER -

In vitro Azole Susceptibility Testing of Japanese Isolates of Terbinafine-Resistant Trichophyton indotineae and Trichophyton rubrum

Abstract

Keywords

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