TY - JOUR
T1 - Improvement of the 99mTc-ECD brain uptake ratio (BUR) method for measurement of cerebral blood flow
AU - Ito, Shigeki
AU - Takaki, Akihiro
AU - Inoue, Shinya
AU - Tomiguchi, Seiji
AU - Shiraishi, Shinya
AU - Akiyama, Yasuhiko
AU - Sasaki, Toshiaki
AU - Odajima, Satoshi
AU - Teraoka, Satomi
AU - Hosoya, Tetsuo
AU - Soma, Tsutomu
AU - Miyazaki, Yoshiharu
AU - Kinuya, Seigo
AU - Yamashita, Yasuyuki
PY - 2012/5
Y1 - 2012/5
N2 - Objective: The brain uptake ratio (BUR) method for the 99mTc-ECD SPECT, a non-invasive measurement method of rCBF, has been used in clinical practice in Japan, because it is simple to use. However, the accuracy of this method is limited, as it has problems in the determination of input function and the regression equation. The purpose of this study is to improve the BUR method by reconstructing the determination process of the input function and regression equation based on measurement of the rCBF by H2 15O PET. Method: The input function was obtained by setting the region of interest on the ascending aorta instead of the aortic arch. The 3DSRT algorithm was used to obtain the anatomically standardized rCBF, and developed a semiautomatic analyzing software using C++ in order to stabilize the repeatability of the improved BUR (IBUR) method. The regression equation for the IBUR method was obtained by the H215O PET rCBFs in 15 patients with the arterial blood sampling method. All the measurements in this study were performed with the patient in the resting state. Result: A good correlation was observed between the rCBF values measured by H2 15O PET and the regional BURs measured by the IBUR method (r = 0.86, p<0.0001). The rCBF values were calculated for only 5 min using a semi-automatic analyzing software. Conclusion: The BUR method was improved by changing the location of the input function from the aortic arch to the ascending aorta based on arterial blood flow dynamics, and reconstructing regression equation based on the rCBF values obtained using H2 15O PET. This finding indicates the potential clinical usefulness of this method.
AB - Objective: The brain uptake ratio (BUR) method for the 99mTc-ECD SPECT, a non-invasive measurement method of rCBF, has been used in clinical practice in Japan, because it is simple to use. However, the accuracy of this method is limited, as it has problems in the determination of input function and the regression equation. The purpose of this study is to improve the BUR method by reconstructing the determination process of the input function and regression equation based on measurement of the rCBF by H2 15O PET. Method: The input function was obtained by setting the region of interest on the ascending aorta instead of the aortic arch. The 3DSRT algorithm was used to obtain the anatomically standardized rCBF, and developed a semiautomatic analyzing software using C++ in order to stabilize the repeatability of the improved BUR (IBUR) method. The regression equation for the IBUR method was obtained by the H215O PET rCBFs in 15 patients with the arterial blood sampling method. All the measurements in this study were performed with the patient in the resting state. Result: A good correlation was observed between the rCBF values measured by H2 15O PET and the regional BURs measured by the IBUR method (r = 0.86, p<0.0001). The rCBF values were calculated for only 5 min using a semi-automatic analyzing software. Conclusion: The BUR method was improved by changing the location of the input function from the aortic arch to the ascending aorta based on arterial blood flow dynamics, and reconstructing regression equation based on the rCBF values obtained using H2 15O PET. This finding indicates the potential clinical usefulness of this method.
KW - Tc-ECD SPECT
KW - Brain uptake ratio
KW - Input function
KW - Non-invasive measurement method
KW - RCBF
UR - https://www.scopus.com/pages/publications/84862658888
U2 - 10.1007/s12149-012-0582-7
DO - 10.1007/s12149-012-0582-7
M3 - 記事
C2 - 22350958
AN - SCOPUS:84862658888
SN - 0914-7187
VL - 26
SP - 351
EP - 358
JO - Annals of Nuclear Medicine
JF - Annals of Nuclear Medicine
IS - 4
ER -