Immunohistochemical Analysis Using Monoclonal Antibody PMab-269 Against Steller Sea Lion Podoplanin

Guanjie Li; Hiroyuki Suzuki; Junko Takei; Masaki Saito; Nohara Goto; Kazuyuki Uchida; Takayuki Nakagawa; Hiroyuki Harada; Tomohiro Tanaka; Teizo Asano; Mika K. Kaneko; Yukinari Kato

doi:10.1089/mab.2021.0055

Immunohistochemical Analysis Using Monoclonal Antibody PMab-269 Against Steller Sea Lion Podoplanin

Guanjie Li
, Hiroyuki Suzuki
, Junko Takei
, Masaki Saito
, Nohara Goto
, Kazuyuki Uchida
, Takayuki Nakagawa
, Hiroyuki Harada
, Tomohiro Tanaka
, Teizo Asano
, Mika K. Kaneko
, Yukinari Kato

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Monoclonal antibodies (mAbs) that specifically target podoplanin (PDPN), a marker for type I alveolar cells, are required for immunohistochemical analyses. Anti-PDPN mAbs are available for many species, including human, mouse, rat, rabbit, dog, cat, bovine, pig, Tasmanian devil, alpaca, tiger, whale, goat, horse, bear, sheep, and California sea lion PDPNs. However, no anti-Steller sea lion PDPN (stePDPN) antibody has been developed. Immunohistochemical analysis showed that an anti-California sea lion PDPN mAb (PMab-269) reacted with type I alveolar cells from the Steller sea lion lung, renal glomeruli and Bowman’s capsules from kidney, and lymphatic endothelial cells from the colon, indicating that PMab-269 is useful for detecting stePDPN.

Original language	English
Pages (from-to)	39-44
Number of pages	6
Journal	Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
Volume	41
Issue number	1
DOIs	https://doi.org/10.1089/mab.2021.0055
State	Published - 1 Feb 2022
Externally published	Yes

Keywords

PDPN
PMab-269
Podoplanin
Steller sea lion

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10.1089/mab.2021.0055

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title = "Immunohistochemical Analysis Using Monoclonal Antibody PMab-269 Against Steller Sea Lion Podoplanin",

abstract = "Monoclonal antibodies (mAbs) that specifically target podoplanin (PDPN), a marker for type I alveolar cells, are required for immunohistochemical analyses. Anti-PDPN mAbs are available for many species, including human, mouse, rat, rabbit, dog, cat, bovine, pig, Tasmanian devil, alpaca, tiger, whale, goat, horse, bear, sheep, and California sea lion PDPNs. However, no anti-Steller sea lion PDPN (stePDPN) antibody has been developed. Immunohistochemical analysis showed that an anti-California sea lion PDPN mAb (PMab-269) reacted with type I alveolar cells from the Steller sea lion lung, renal glomeruli and Bowman{\textquoteright}s capsules from kidney, and lymphatic endothelial cells from the colon, indicating that PMab-269 is useful for detecting stePDPN.",

keywords = "PDPN, PMab-269, Podoplanin, Steller sea lion",

author = "Guanjie Li and Hiroyuki Suzuki and Junko Takei and Masaki Saito and Nohara Goto and Kazuyuki Uchida and Takayuki Nakagawa and Hiroyuki Harada and Tomohiro Tanaka and Teizo Asano and Kaneko, \{Mika K.\} and Yukinari Kato",

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doi = "10.1089/mab.2021.0055",

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AU - Li, Guanjie

AU - Suzuki, Hiroyuki

AU - Takei, Junko

AU - Saito, Masaki

AU - Goto, Nohara

AU - Uchida, Kazuyuki

AU - Nakagawa, Takayuki

AU - Harada, Hiroyuki

AU - Tanaka, Tomohiro

AU - Asano, Teizo

AU - Kaneko, Mika K.

AU - Kato, Yukinari

N1 - Publisher Copyright: © Mary Ann Liebert, Inc.

PY - 2022/2/1

Y1 - 2022/2/1

N2 - Monoclonal antibodies (mAbs) that specifically target podoplanin (PDPN), a marker for type I alveolar cells, are required for immunohistochemical analyses. Anti-PDPN mAbs are available for many species, including human, mouse, rat, rabbit, dog, cat, bovine, pig, Tasmanian devil, alpaca, tiger, whale, goat, horse, bear, sheep, and California sea lion PDPNs. However, no anti-Steller sea lion PDPN (stePDPN) antibody has been developed. Immunohistochemical analysis showed that an anti-California sea lion PDPN mAb (PMab-269) reacted with type I alveolar cells from the Steller sea lion lung, renal glomeruli and Bowman’s capsules from kidney, and lymphatic endothelial cells from the colon, indicating that PMab-269 is useful for detecting stePDPN.

AB - Monoclonal antibodies (mAbs) that specifically target podoplanin (PDPN), a marker for type I alveolar cells, are required for immunohistochemical analyses. Anti-PDPN mAbs are available for many species, including human, mouse, rat, rabbit, dog, cat, bovine, pig, Tasmanian devil, alpaca, tiger, whale, goat, horse, bear, sheep, and California sea lion PDPNs. However, no anti-Steller sea lion PDPN (stePDPN) antibody has been developed. Immunohistochemical analysis showed that an anti-California sea lion PDPN mAb (PMab-269) reacted with type I alveolar cells from the Steller sea lion lung, renal glomeruli and Bowman’s capsules from kidney, and lymphatic endothelial cells from the colon, indicating that PMab-269 is useful for detecting stePDPN.

KW - PDPN

KW - PMab-269

KW - Podoplanin

KW - Steller sea lion

UR - https://www.scopus.com/pages/publications/85125432706

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DO - 10.1089/mab.2021.0055

M3 - 記事

C2 - 35225666

AN - SCOPUS:85125432706

SN - 2167-9436

VL - 41

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EP - 44

JO - Monoclonal Antibodies in Immunodiagnosis and Immunotherapy

JF - Monoclonal Antibodies in Immunodiagnosis and Immunotherapy

IS - 1

ER -

Immunohistochemical Analysis Using Monoclonal Antibody PMab-269 Against Steller Sea Lion Podoplanin

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Keywords

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