I-123 metaiodobenzylguanidine myocardial scintigraphy in a patient with Brugada syndrome

The Brugada syndrome has characteristic electrocardiographic (ECG) findings: a right bundle branch block (RBBB) pattern with normal Q-T interval and S-T elevation in V₁, V₂, and V₃. The ECG findings are unrelated to a serum electrolyte abnormality, structural heart disease, or ischemia. Patients with this syndrome have an increased incidence of syncope attacks and a greater possibility of sudden death. I-123 metaiodobenzylguanidine (MIBG) myocardial scintigraphy in a patient with the Brugada syndrome showed decreased I-123 MIBG uptake in the left ventricular myocardium. This finding suggested a local sympathetic nerve abnormality in the left ventricular myocardium, as indicated in previous reports.