Human P-glycoprotein as a multi-drug transporter analyzed by using transepithelial transport system.

K. Ueda; T. Saeki; M. Hirai; Y. Tanigawara; K. Tanaka; M. Okamura; M. Yasuhara; R. Hori; K. Inui; T. Komano

Human P-glycoprotein as a multi-drug transporter analyzed by using transepithelial transport system.

K. Ueda
, T. Saeki
, M. Hirai
, Y. Tanigawara
, K. Tanaka
, M. Okamura
, M. Yasuhara
, R. Hori
, K. Inui
, T. Komano

Kyoto University

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

To analyze the mechanism of drug transport, mechanism of inhibitors, and physiological substrates of human P-glycoprotein, we established a transepithelial transport system by introducing MDR1 cDNA into LLC-PK1, a pig kidney epithelial cell line. P-glycoprotein functions as a steroid transporter as well as a drug transporter as physiological functions. P-glycoprotein also transports MDR modulators such as cyclosporin A, FK506, and calcium channel blockers.

Original language	English
Pages (from-to)	S67-71
Journal	Journal of Physiological Sciences
Volume	44 Suppl 2
State	Published - 1994
Externally published	Yes

Cite this

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title = "Human P-glycoprotein as a multi-drug transporter analyzed by using transepithelial transport system.",

abstract = "To analyze the mechanism of drug transport, mechanism of inhibitors, and physiological substrates of human P-glycoprotein, we established a transepithelial transport system by introducing MDR1 cDNA into LLC-PK1, a pig kidney epithelial cell line. P-glycoprotein functions as a steroid transporter as well as a drug transporter as physiological functions. P-glycoprotein also transports MDR modulators such as cyclosporin A, FK506, and calcium channel blockers.",

author = "K. Ueda and T. Saeki and M. Hirai and Y. Tanigawara and K. Tanaka and M. Okamura and M. Yasuhara and R. Hori and K. Inui and T. Komano",

year = "1994",

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volume = "44 Suppl 2",

pages = "S67--71",

journal = "Journal of Physiological Sciences",

issn = "0021-521X",

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T1 - Human P-glycoprotein as a multi-drug transporter analyzed by using transepithelial transport system.

AU - Ueda, K.

AU - Saeki, T.

AU - Hirai, M.

AU - Tanigawara, Y.

AU - Tanaka, K.

AU - Okamura, M.

AU - Yasuhara, M.

AU - Hori, R.

AU - Inui, K.

AU - Komano, T.

PY - 1994

Y1 - 1994

N2 - To analyze the mechanism of drug transport, mechanism of inhibitors, and physiological substrates of human P-glycoprotein, we established a transepithelial transport system by introducing MDR1 cDNA into LLC-PK1, a pig kidney epithelial cell line. P-glycoprotein functions as a steroid transporter as well as a drug transporter as physiological functions. P-glycoprotein also transports MDR modulators such as cyclosporin A, FK506, and calcium channel blockers.

AB - To analyze the mechanism of drug transport, mechanism of inhibitors, and physiological substrates of human P-glycoprotein, we established a transepithelial transport system by introducing MDR1 cDNA into LLC-PK1, a pig kidney epithelial cell line. P-glycoprotein functions as a steroid transporter as well as a drug transporter as physiological functions. P-glycoprotein also transports MDR modulators such as cyclosporin A, FK506, and calcium channel blockers.

UR - https://www.scopus.com/pages/publications/0028708076

M3 - 記事

C2 - 7538609

AN - SCOPUS:0028708076

SN - 0021-521X

VL - 44 Suppl 2

SP - S67-71

JO - Journal of Physiological Sciences

JF - Journal of Physiological Sciences

ER -

Human P-glycoprotein as a multi-drug transporter analyzed by using transepithelial transport system.

Abstract

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