Halenaquinone inhibits RANKL-induced osteoclastogenesis

Sachiko Tsukamoto; Tomoharu Takeuchi; Tetsuro Kawabata; Hikaru Kato; Michiko Yamakuma; Kanae Matsuo; Ahmed H. El-Desoky; Fitje Losung; Remy E.P. Mangindaan; Nicole J. De Voogd; Yoichiro Arata; Hideyoshi Yokosawa

doi:10.1016/j.bmcl.2014.09.043

Halenaquinone inhibits RANKL-induced osteoclastogenesis

Sachiko Tsukamoto, Tomoharu Takeuchi, Tetsuro Kawabata, Hikaru Kato, Michiko Yamakuma, Kanae Matsuo, Ahmed H. El-Desoky, Fitje Losung, Remy E.P. Mangindaan, Nicole J. De Voogd, Yoichiro Arata, Hideyoshi Yokosawa

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Halenaquinone was isolated from the marine sponge Petrosia alfiani as an inhibitor of osteoclastogenic differentiation of murine RAW264 cells. It inhibited the RANKL (receptor activator of nuclear factor-κB ligand)-induced upregulation of TRAP (tartrate-resistant acid phosphatase) activity as well as the formation of multinuclear osteoclasts. In addition, halenaquinone substantially suppressed RANKL-induced IκB degradation and Akt phosphorylation. Thus, these results suggest that halenaquinone inhibits RANKL-induced osteoclastogenesis at least by suppressing the NF-κB and Akt signaling pathways.

Original language	English
Pages (from-to)	5315-5317
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	24
Issue number	22
DOIs	https://doi.org/10.1016/j.bmcl.2014.09.043
State	Published - 15 Nov 2014
Externally published	Yes

Keywords

Halenaquinone
Marine sponge
Osteoclastogenesis
Petrosia alfiani

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10.1016/j.bmcl.2014.09.043

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title = "Halenaquinone inhibits RANKL-induced osteoclastogenesis",

abstract = "Halenaquinone was isolated from the marine sponge Petrosia alfiani as an inhibitor of osteoclastogenic differentiation of murine RAW264 cells. It inhibited the RANKL (receptor activator of nuclear factor-κB ligand)-induced upregulation of TRAP (tartrate-resistant acid phosphatase) activity as well as the formation of multinuclear osteoclasts. In addition, halenaquinone substantially suppressed RANKL-induced IκB degradation and Akt phosphorylation. Thus, these results suggest that halenaquinone inhibits RANKL-induced osteoclastogenesis at least by suppressing the NF-κB and Akt signaling pathways.",

keywords = "Halenaquinone, Marine sponge, Osteoclastogenesis, Petrosia alfiani",

author = "Sachiko Tsukamoto and Tomoharu Takeuchi and Tetsuro Kawabata and Hikaru Kato and Michiko Yamakuma and Kanae Matsuo and El-Desoky, {Ahmed H.} and Fitje Losung and Mangindaan, {Remy E.P.} and {De Voogd}, {Nicole J.} and Yoichiro Arata and Hideyoshi Yokosawa",

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doi = "10.1016/j.bmcl.2014.09.043",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Halenaquinone inhibits RANKL-induced osteoclastogenesis

AU - Tsukamoto, Sachiko

AU - Takeuchi, Tomoharu

AU - Kawabata, Tetsuro

AU - Kato, Hikaru

AU - Yamakuma, Michiko

AU - Matsuo, Kanae

AU - El-Desoky, Ahmed H.

AU - Losung, Fitje

AU - Mangindaan, Remy E.P.

AU - De Voogd, Nicole J.

AU - Arata, Yoichiro

AU - Yokosawa, Hideyoshi

PY - 2014/11/15

Y1 - 2014/11/15

N2 - Halenaquinone was isolated from the marine sponge Petrosia alfiani as an inhibitor of osteoclastogenic differentiation of murine RAW264 cells. It inhibited the RANKL (receptor activator of nuclear factor-κB ligand)-induced upregulation of TRAP (tartrate-resistant acid phosphatase) activity as well as the formation of multinuclear osteoclasts. In addition, halenaquinone substantially suppressed RANKL-induced IκB degradation and Akt phosphorylation. Thus, these results suggest that halenaquinone inhibits RANKL-induced osteoclastogenesis at least by suppressing the NF-κB and Akt signaling pathways.

AB - Halenaquinone was isolated from the marine sponge Petrosia alfiani as an inhibitor of osteoclastogenic differentiation of murine RAW264 cells. It inhibited the RANKL (receptor activator of nuclear factor-κB ligand)-induced upregulation of TRAP (tartrate-resistant acid phosphatase) activity as well as the formation of multinuclear osteoclasts. In addition, halenaquinone substantially suppressed RANKL-induced IκB degradation and Akt phosphorylation. Thus, these results suggest that halenaquinone inhibits RANKL-induced osteoclastogenesis at least by suppressing the NF-κB and Akt signaling pathways.

KW - Halenaquinone

KW - Marine sponge

KW - Osteoclastogenesis

KW - Petrosia alfiani

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U2 - 10.1016/j.bmcl.2014.09.043

DO - 10.1016/j.bmcl.2014.09.043

M3 - 記事

C2 - 25278237

AN - SCOPUS:84908430507

SN - 0960-894X

VL - 24

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EP - 5317

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 22

ER -

Halenaquinone inhibits RANKL-induced osteoclastogenesis

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Keywords

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