Fibrinogen levels and Bleeding Risk in Adult Extracorporeal Cardiopulmonary Resuscitation: Multicenter Observational Study Subanalysis

Seiya Kanou; Eiji Nakatani; Tetsumei Urano; Hatoko Sasaki; Akihiko Inoue; Toru Hifumi; Tetsuya Sakamoto; Yasuhiro Kuroda; Yoshihiro Tanaka; Hirotaka Sawano; Yuko Egawa; Shunichi Kato; Naofumi Bunya; Takehiko Kasai; Shinichi Ijuin; Shinichi Nakayama; Jun Kanda; Toru Takiguchi; Shoji Yokobori; Hiroaki Takada; Kazushige Inoue; Ichiro Takeuchi; Hiroshi Honzawa; Makoto Kobayashi; Tomohiro Hamagami; Wataru Takayama; Yasuhiro Otomo; Kunihiko Maekawa; Takafumi Shimizu; Satoshi Nara; Michitaka Nasu; Kuniko Takahashi; Yoshihiro Hagiwara; Shigeki Kushimoto; Reo Fukuda; Takayuki Ogura; Shin-ichiro Shiraishi; Ryosuke Zushi; Norio Otani; Migaku Kikuchi; Kazuhiro Watanabe; Takuo Nakagami; Tomohisa Shoko; Nobuya Kitamura; Takayuki Otani; Yoshinori Matsuoka; Makoto Aoki; Masaaki Sakuraya; Hideki Arimoto; Koichiro Homma; Hiromichi Naito; Shunichiro Nakao; Tomoya Okazaki; Yoshio Tahara; Hiroshi Okamoto; Jun Kunikata; Hideto Yokoi

doi:10.1016/j.rpth.2025.102700

Fibrinogen levels and Bleeding Risk in Adult Extracorporeal Cardiopulmonary Resuscitation: Multicenter Observational Study Subanalysis

Seiya Kanou
, Eiji Nakatani
, Tetsumei Urano
, Hatoko Sasaki
, Akihiko Inoue
, Toru Hifumi
, Tetsuya Sakamoto
, Yasuhiro Kuroda
, Yoshihiro Tanaka
, Hirotaka Sawano
, Yuko Egawa
, Shunichi Kato
, Naofumi Bunya
, Takehiko Kasai
, Shinichi Ijuin
, Shinichi Nakayama
, Jun Kanda
, Toru Takiguchi
, Shoji Yokobori
, Hiroaki Takada

Kazushige Inoue, Ichiro Takeuchi, Hiroshi Honzawa, Makoto Kobayashi, Tomohiro Hamagami, Wataru Takayama, Yasuhiro Otomo, Kunihiko Maekawa, Takafumi Shimizu, Satoshi Nara, Michitaka Nasu, Kuniko Takahashi, Yoshihiro Hagiwara, Shigeki Kushimoto, Reo Fukuda, Takayuki Ogura, Shin-ichiro Shiraishi, Ryosuke Zushi, Norio Otani, Migaku Kikuchi, Kazuhiro Watanabe, Takuo Nakagami, Tomohisa Shoko, Nobuya Kitamura, Takayuki Otani, Yoshinori Matsuoka, Makoto Aoki, Masaaki Sakuraya, Hideki Arimoto, Koichiro Homma, Hiromichi Naito, Shunichiro Nakao, Tomoya Okazaki, Yoshio Tahara, Hiroshi Okamoto, Jun Kunikata, Hideto Yokoi

School of Medicine

Research output: Contribution to journal › Article

2 Scopus citations

Abstract

•Hypofibrinogenemia frequently occurs in extracorporeal cardiopulmonary resuscitation (ECPR) and may heighten bleeding risk. This subanalysis of a multicenter observational study (SAVE-J II) included 2,100 adult patients receiving ECPR after out-of-hospital cardiac arrest at 36 facilities in Japan.•Overall, 7.5% of patients experienced non-cannulation hemorrhagic complications, and those with fibrinogen levels below 140 mg/dL at ECPR initiation faced significantly higher bleeding risk. These findings underscore the importance of monitoring and managing fibrinogen levels in ECPR to mitigate hemorrhagic events and improve patient outcomes.

Original language	English
Pages (from-to)	102700-102700
Number of pages	1
Journal	Research and Practice in Thrombosis and Haemostasis
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/j.rpth.2025.102700
State	Published - Feb 2025

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Kanou, S., Nakatani, E., Urano, T., Sasaki, H., Inoue, A., Hifumi, T., Sakamoto, T., Kuroda, Y., Tanaka, Y., Sawano, H., Egawa, Y., Kato, S., Bunya, N., Kasai, T., Ijuin, S., Nakayama, S., Kanda, J., Takiguchi, T., Yokobori, S., ... Yokoi, H. (2025). Fibrinogen levels and Bleeding Risk in Adult Extracorporeal Cardiopulmonary Resuscitation: Multicenter Observational Study Subanalysis. Research and Practice in Thrombosis and Haemostasis, 9(2), 102700-102700. https://doi.org/10.1016/j.rpth.2025.102700

@article{5cd64af92dc445629d5c7ff7e06ac2b1,

title = "Fibrinogen levels and Bleeding Risk in Adult Extracorporeal Cardiopulmonary Resuscitation: Multicenter Observational Study Subanalysis",

abstract = "•Hypofibrinogenemia frequently occurs in extracorporeal cardiopulmonary resuscitation (ECPR) and may heighten bleeding risk. This subanalysis of a multicenter observational study (SAVE-J II) included 2,100 adult patients receiving ECPR after out-of-hospital cardiac arrest at 36 facilities in Japan.•Overall, 7.5\% of patients experienced non-cannulation hemorrhagic complications, and those with fibrinogen levels below 140 mg/dL at ECPR initiation faced significantly higher bleeding risk. These findings underscore the importance of monitoring and managing fibrinogen levels in ECPR to mitigate hemorrhagic events and improve patient outcomes.",

author = "Seiya Kanou and Eiji Nakatani and Tetsumei Urano and Hatoko Sasaki and Akihiko Inoue and Toru Hifumi and Tetsuya Sakamoto and Yasuhiro Kuroda and Yoshihiro Tanaka and Hirotaka Sawano and Yuko Egawa and Shunichi Kato and Naofumi Bunya and Takehiko Kasai and Shinichi Ijuin and Shinichi Nakayama and Jun Kanda and Toru Takiguchi and Shoji Yokobori and Hiroaki Takada and Kazushige Inoue and Ichiro Takeuchi and Hiroshi Honzawa and Makoto Kobayashi and Tomohiro Hamagami and Wataru Takayama and Yasuhiro Otomo and Kunihiko Maekawa and Takafumi Shimizu and Satoshi Nara and Michitaka Nasu and Kuniko Takahashi and Yoshihiro Hagiwara and Shigeki Kushimoto and Reo Fukuda and Takayuki Ogura and Shin-ichiro Shiraishi and Ryosuke Zushi and Norio Otani and Migaku Kikuchi and Kazuhiro Watanabe and Takuo Nakagami and Tomohisa Shoko and Nobuya Kitamura and Takayuki Otani and Yoshinori Matsuoka and Makoto Aoki and Masaaki Sakuraya and Hideki Arimoto and Koichiro Homma and Hiromichi Naito and Shunichiro Nakao and Tomoya Okazaki and Yoshio Tahara and Hiroshi Okamoto and Jun Kunikata and Hideto Yokoi",

note = "Is international journal: true",

year = "2025",

month = feb,

doi = "10.1016/j.rpth.2025.102700",

language = "英語",

volume = "9",

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journal = "Research and Practice in Thrombosis and Haemostasis",

issn = "2475-0379",

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Kanou, S, Nakatani, E, Urano, T, Sasaki, H, Inoue, A, Hifumi, T, Sakamoto, T, Kuroda, Y, Tanaka, Y, Sawano, H, Egawa, Y, Kato, S, Bunya, N, Kasai, T, Ijuin, S, Nakayama, S, Kanda, J, Takiguchi, T, Yokobori, S, Takada, H, Inoue, K, Takeuchi, I, Honzawa, H, Kobayashi, M, Hamagami, T, Takayama, W, Otomo, Y, Maekawa, K, Shimizu, T, Nara, S, Nasu, M, Takahashi, K, Hagiwara, Y, Kushimoto, S, Fukuda, R, Ogura, T, Shiraishi, S, Zushi, R, Otani, N, Kikuchi, M, Watanabe, K, Nakagami, T, Shoko, T, Kitamura, N, Otani, T, Matsuoka, Y, Aoki, M, Sakuraya, M, Arimoto, H, Homma, K, Naito, H, Nakao, S, Okazaki, T, Tahara, Y, Okamoto, H, Kunikata, J & Yokoi, H 2025, 'Fibrinogen levels and Bleeding Risk in Adult Extracorporeal Cardiopulmonary Resuscitation: Multicenter Observational Study Subanalysis', Research and Practice in Thrombosis and Haemostasis, vol. 9, no. 2, pp. 102700-102700. https://doi.org/10.1016/j.rpth.2025.102700

TY - JOUR

T1 - Fibrinogen levels and Bleeding Risk in Adult Extracorporeal Cardiopulmonary Resuscitation: Multicenter Observational Study Subanalysis

AU - Kanou, Seiya

AU - Nakatani, Eiji

AU - Urano, Tetsumei

AU - Sasaki, Hatoko

AU - Inoue, Akihiko

AU - Hifumi, Toru

AU - Sakamoto, Tetsuya

AU - Kuroda, Yasuhiro

AU - Tanaka, Yoshihiro

AU - Sawano, Hirotaka

AU - Egawa, Yuko

AU - Kato, Shunichi

AU - Bunya, Naofumi

AU - Kasai, Takehiko

AU - Ijuin, Shinichi

AU - Nakayama, Shinichi

AU - Kanda, Jun

AU - Takiguchi, Toru

AU - Yokobori, Shoji

AU - Takada, Hiroaki

AU - Inoue, Kazushige

AU - Takeuchi, Ichiro

AU - Honzawa, Hiroshi

AU - Kobayashi, Makoto

AU - Hamagami, Tomohiro

AU - Takayama, Wataru

AU - Otomo, Yasuhiro

AU - Maekawa, Kunihiko

AU - Shimizu, Takafumi

AU - Nara, Satoshi

AU - Nasu, Michitaka

AU - Takahashi, Kuniko

AU - Hagiwara, Yoshihiro

AU - Kushimoto, Shigeki

AU - Fukuda, Reo

AU - Ogura, Takayuki

AU - Shiraishi, Shin-ichiro

AU - Zushi, Ryosuke

AU - Otani, Norio

AU - Kikuchi, Migaku

AU - Watanabe, Kazuhiro

AU - Nakagami, Takuo

AU - Shoko, Tomohisa

AU - Kitamura, Nobuya

AU - Otani, Takayuki

AU - Matsuoka, Yoshinori

AU - Aoki, Makoto

AU - Sakuraya, Masaaki

AU - Arimoto, Hideki

AU - Homma, Koichiro

AU - Naito, Hiromichi

AU - Nakao, Shunichiro

AU - Okazaki, Tomoya

AU - Tahara, Yoshio

AU - Okamoto, Hiroshi

AU - Kunikata, Jun

AU - Yokoi, Hideto

N1 - Is international journal: true

PY - 2025/2

Y1 - 2025/2

N2 - •Hypofibrinogenemia frequently occurs in extracorporeal cardiopulmonary resuscitation (ECPR) and may heighten bleeding risk. This subanalysis of a multicenter observational study (SAVE-J II) included 2,100 adult patients receiving ECPR after out-of-hospital cardiac arrest at 36 facilities in Japan.•Overall, 7.5% of patients experienced non-cannulation hemorrhagic complications, and those with fibrinogen levels below 140 mg/dL at ECPR initiation faced significantly higher bleeding risk. These findings underscore the importance of monitoring and managing fibrinogen levels in ECPR to mitigate hemorrhagic events and improve patient outcomes.

AB - •Hypofibrinogenemia frequently occurs in extracorporeal cardiopulmonary resuscitation (ECPR) and may heighten bleeding risk. This subanalysis of a multicenter observational study (SAVE-J II) included 2,100 adult patients receiving ECPR after out-of-hospital cardiac arrest at 36 facilities in Japan.•Overall, 7.5% of patients experienced non-cannulation hemorrhagic complications, and those with fibrinogen levels below 140 mg/dL at ECPR initiation faced significantly higher bleeding risk. These findings underscore the importance of monitoring and managing fibrinogen levels in ECPR to mitigate hemorrhagic events and improve patient outcomes.

U2 - 10.1016/j.rpth.2025.102700

DO - 10.1016/j.rpth.2025.102700

M3 - 記事

C2 - 40129565

SN - 2475-0379

VL - 9

SP - 102700

EP - 102700

JO - Research and Practice in Thrombosis and Haemostasis

JF - Research and Practice in Thrombosis and Haemostasis

IS - 2

ER -

Fibrinogen levels and Bleeding Risk in Adult Extracorporeal Cardiopulmonary Resuscitation: Multicenter Observational Study Subanalysis

Abstract

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