Expression patterns of the lysophospholipid receptor genes during mouse early development

Hideyo Ohuchi; Aska Hamada; Hironao Matsuda; Akira Takagi; Masayuki Tanaka; Junken Aoki; Hiroyuki Arai; Sumihare Noji

doi:10.1002/dvdy.21736

Expression patterns of the lysophospholipid receptor genes during mouse early development

Hideyo Ohuchi
, Aska Hamada
, Hironao Matsuda
, Akira Takagi
, Masayuki Tanaka
, Junken Aoki
, Hiroyuki Arai
, Sumihare Noji

Tokushima University
The University of Tokyo
Tohoku University
Japan Science and Technology Agency

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

Lysophospholipids (LPs) such as lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are known to mediate various biological responses, including cell proliferation, migration, and differentiation. To better understand the role of these lipids in mammalian early development, we applied whole-mount in situ hybridization techniques to E8.5 to E12.5 mouse embryos. We determined the expression patterns of the following LP receptor genes, which belong to the G protein-coupled receptor (GPCR) family: EDG1 to EDG8 (S1P ₁ to S1P₅ and LPA₁ to LPA₃), LPA₄ (GPR23 /P2Y9), and LPA₅ (GPR92). We found that the S1P/LPA receptor genes exhibit overlapping expression patterns in a variety of organ primordia, including the developing brain and cardiovascular system, presomitic mesoderm and somites, branchial arches, and limb buds. These results suggest that multiple receptor systems for LPA/S1P lysophospholipids may be functioning during organogenesis.

Original language	English
Pages (from-to)	3280-3294
Number of pages	15
Journal	Developmental Dynamics
Volume	237
Issue number	11
DOIs	https://doi.org/10.1002/dvdy.21736
State	Published - Nov 2008
Externally published	Yes

Keywords

Edg
Endothelial differentiation genes
G protein-coupled receptors
Gna13
GPR23
GPR92
LPA
Lysophosphatidic acid
S1P
Sphingosine-1-phosphate

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10.1002/dvdy.21736

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title = "Expression patterns of the lysophospholipid receptor genes during mouse early development",

abstract = "Lysophospholipids (LPs) such as lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are known to mediate various biological responses, including cell proliferation, migration, and differentiation. To better understand the role of these lipids in mammalian early development, we applied whole-mount in situ hybridization techniques to E8.5 to E12.5 mouse embryos. We determined the expression patterns of the following LP receptor genes, which belong to the G protein-coupled receptor (GPCR) family: EDG1 to EDG8 (S1P 1 to S1P5 and LPA1 to LPA3), LPA4 (GPR23 /P2Y9), and LPA5 (GPR92). We found that the S1P/LPA receptor genes exhibit overlapping expression patterns in a variety of organ primordia, including the developing brain and cardiovascular system, presomitic mesoderm and somites, branchial arches, and limb buds. These results suggest that multiple receptor systems for LPA/S1P lysophospholipids may be functioning during organogenesis.",

keywords = "Edg, Endothelial differentiation genes, G protein-coupled receptors, Gna13, GPR23, GPR92, LPA, Lysophosphatidic acid, S1P, Sphingosine-1-phosphate",

author = "Hideyo Ohuchi and Aska Hamada and Hironao Matsuda and Akira Takagi and Masayuki Tanaka and Junken Aoki and Hiroyuki Arai and Sumihare Noji",

year = "2008",

month = nov,

doi = "10.1002/dvdy.21736",

language = "英語",

volume = "237",

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AU - Ohuchi, Hideyo

AU - Hamada, Aska

AU - Matsuda, Hironao

AU - Takagi, Akira

AU - Tanaka, Masayuki

AU - Aoki, Junken

AU - Arai, Hiroyuki

AU - Noji, Sumihare

PY - 2008/11

Y1 - 2008/11

N2 - Lysophospholipids (LPs) such as lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are known to mediate various biological responses, including cell proliferation, migration, and differentiation. To better understand the role of these lipids in mammalian early development, we applied whole-mount in situ hybridization techniques to E8.5 to E12.5 mouse embryos. We determined the expression patterns of the following LP receptor genes, which belong to the G protein-coupled receptor (GPCR) family: EDG1 to EDG8 (S1P 1 to S1P5 and LPA1 to LPA3), LPA4 (GPR23 /P2Y9), and LPA5 (GPR92). We found that the S1P/LPA receptor genes exhibit overlapping expression patterns in a variety of organ primordia, including the developing brain and cardiovascular system, presomitic mesoderm and somites, branchial arches, and limb buds. These results suggest that multiple receptor systems for LPA/S1P lysophospholipids may be functioning during organogenesis.

AB - Lysophospholipids (LPs) such as lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are known to mediate various biological responses, including cell proliferation, migration, and differentiation. To better understand the role of these lipids in mammalian early development, we applied whole-mount in situ hybridization techniques to E8.5 to E12.5 mouse embryos. We determined the expression patterns of the following LP receptor genes, which belong to the G protein-coupled receptor (GPCR) family: EDG1 to EDG8 (S1P 1 to S1P5 and LPA1 to LPA3), LPA4 (GPR23 /P2Y9), and LPA5 (GPR92). We found that the S1P/LPA receptor genes exhibit overlapping expression patterns in a variety of organ primordia, including the developing brain and cardiovascular system, presomitic mesoderm and somites, branchial arches, and limb buds. These results suggest that multiple receptor systems for LPA/S1P lysophospholipids may be functioning during organogenesis.

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KW - Endothelial differentiation genes

KW - G protein-coupled receptors

KW - Gna13

KW - GPR23

KW - GPR92

KW - LPA

KW - Lysophosphatidic acid

KW - S1P

KW - Sphingosine-1-phosphate

UR - https://www.scopus.com/pages/publications/55549114728

U2 - 10.1002/dvdy.21736

DO - 10.1002/dvdy.21736

M3 - 記事

C2 - 18924241

AN - SCOPUS:55549114728

SN - 1058-8388

VL - 237

SP - 3280

EP - 3294

JO - Developmental Dynamics

JF - Developmental Dynamics

IS - 11

ER -

Expression patterns of the lysophospholipid receptor genes during mouse early development

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