TY - GEN
T1 - Evaluation of damage on vascular endothelial cells under exposure of burst wave with presence of lipid bubbles
AU - Saito, Tatsuya
AU - Seki, Masakazu
AU - Nozaki, Kiyonobu
AU - Masuda, Kohji
AU - Miyamoto, Yoshitaka
AU - Omata, Daiki
AU - Suzuki, Ryo
N1 - Publisher Copyright:
© 2020 IEEE.
PY - 2020/9/7
Y1 - 2020/9/7
N2 - We have previously reported methods for the active control of microbubbles, and the use of cells surrounded by microbubbles to deliver drugs in human blood vessels using acoustic radiation force. However, the effect and degree of damage to blood vessel walls has not previously been studied with respect to the application of continuous and burst ultrasound emissions. We examined the destruction of lipid bubbles, which were injected into the circulation path, to measure the fragility under various conditions of ultrasound exposure. Next, the cell viability of vascular endothelial cells in the presence of bubbles was verified, where the various conditions of ultrasound were irradiated to suspension composed with the cells and the bubbles. We confirmed that cell viability decreased in the presence of bubbles in proportion to a sound pressure and a duty ratio. Furthermore, we found a significant relationship between the cell viability and the destruction coefficient of bubbles.
AB - We have previously reported methods for the active control of microbubbles, and the use of cells surrounded by microbubbles to deliver drugs in human blood vessels using acoustic radiation force. However, the effect and degree of damage to blood vessel walls has not previously been studied with respect to the application of continuous and burst ultrasound emissions. We examined the destruction of lipid bubbles, which were injected into the circulation path, to measure the fragility under various conditions of ultrasound exposure. Next, the cell viability of vascular endothelial cells in the presence of bubbles was verified, where the various conditions of ultrasound were irradiated to suspension composed with the cells and the bubbles. We confirmed that cell viability decreased in the presence of bubbles in proportion to a sound pressure and a duty ratio. Furthermore, we found a significant relationship between the cell viability and the destruction coefficient of bubbles.
KW - Destruction coefficient
KW - Lipid bubble
KW - Vascular endothelial cell
KW - Viability
UR - https://www.scopus.com/pages/publications/85097911864
U2 - 10.1109/IUS46767.2020.9251363
DO - 10.1109/IUS46767.2020.9251363
M3 - 会議への寄与
AN - SCOPUS:85097911864
T3 - IEEE International Ultrasonics Symposium, IUS
BT - IUS 2020 - International Ultrasonics Symposium, Proceedings
PB - IEEE Computer Society
T2 - 2020 IEEE International Ultrasonics Symposium, IUS 2020
Y2 - 7 September 2020 through 11 September 2020
ER -