Eleven secondary cancers after hematopoietic stem cell transplantation using a total body irradiation-based regimen in 370 consecutive pediatric and adult patients

Mami Omori, Hideomi Yamashita, Akihito Shinohara, Mineo Kurokawa, Jyunko Takita, Mitsuteru Hiwatari, Keiichi Nakagawa

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

About the bone marrow transplantation that high dose chemotherapy and total-body irradiation (TBI) are used for as conditioning regimen, a late toxicity may become the problem in the long-term survival patient. One of the toxicities which has been implied to be associated with TBI is secondary cacinogenesis. Between June 1995 and December 2010, 370 patients who were undergoing allogeneic hematopoietic stem cell transplantation using a TBIbased regimen at our department, were the subjects of this study. Eleven secondary cancers occurred in 10 patients. The median time from transplantation to diagnosis of a secondary cancer was 6.8 years. In this analysis, the cumulative incidence rate of secondary cancer at 5 and 10 years was 2.15% and 6.46%, respectively after TBI in our institution.

Original languageEnglish
Article number424
Pages (from-to)1-5
Number of pages5
JournalSpringerPlus
Volume2
Issue number1
DOIs
StatePublished - 2013
Externally publishedYes

Keywords

  • Bone marrow transplantation
  • Secondary cancer
  • Total body irradiation

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