TY - JOUR
T1 - Effects of Oren-gedoku-to and Unsei-in, Chinese traditional medicines, on interleukin-8 and superoxide dismutase in rats
AU - Wang, L. M.
AU - Yamamoto, T.
AU - Wang, X. X.
AU - Yang, L.
AU - Koike, Y.
AU - Shiba, K.
AU - Mineshita, S.
PY - 1997/1
Y1 - 1997/1
N2 - This study was conducted to elucidate the mechanisms of action of two Chinese traditional drugs, Orengedoku-to and Unsei-in, which have been used for many years in the treatment of inflammatory disorders. In rats with acetic acid-induced inflammation, both drugs reduced interleukin-8 concentrations in the serum. Neither drug significantly affected superoxide dismutase activity in the serum, although Unsei-in increased superoxide dismutase activity in liver after 1 month of administration. Oren-gedoku-to showed no significant effect on liver superoxide dismutase activity. It was considered that these medicines exert their anti-inflammatory effects mainly on the early stages of inflammation, wherein increased capillary permeability and migration of leucocytes occur.
AB - This study was conducted to elucidate the mechanisms of action of two Chinese traditional drugs, Orengedoku-to and Unsei-in, which have been used for many years in the treatment of inflammatory disorders. In rats with acetic acid-induced inflammation, both drugs reduced interleukin-8 concentrations in the serum. Neither drug significantly affected superoxide dismutase activity in the serum, although Unsei-in increased superoxide dismutase activity in liver after 1 month of administration. Oren-gedoku-to showed no significant effect on liver superoxide dismutase activity. It was considered that these medicines exert their anti-inflammatory effects mainly on the early stages of inflammation, wherein increased capillary permeability and migration of leucocytes occur.
UR - https://www.scopus.com/pages/publications/0031027658
U2 - 10.1111/j.2042-7158.1997.tb06760.x
DO - 10.1111/j.2042-7158.1997.tb06760.x
M3 - 記事
C2 - 9120759
AN - SCOPUS:0031027658
SN - 0022-3573
VL - 49
SP - 102
EP - 104
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
IS - 1
ER -