Effect of losartan and benzbromarone on the level of human urate transporter 1 mRNA

Yora Nindita; Toshihiro Hamada; Udin Bahrudin; Makoto Hosoyamada; Kimiyoshi Ichida; Chisato Iwai; Sunao Urashima; Narimasa Kuwabara; Sulistiyati Bayu Utami; Einosuke Mizuta; Kensaku Yamada; Osamu Igawa; Chiaki Shigemasa; Haruaki Ninomiya; Takuya Tsuchihashi; Ichiro Hisatome

doi:10.1055/s-0031-1296271

Effect of losartan and benzbromarone on the level of human urate transporter 1 mRNA

Yora Nindita, Toshihiro Hamada, Udin Bahrudin, Makoto Hosoyamada, Kimiyoshi Ichida, Chisato Iwai, Sunao Urashima, Narimasa Kuwabara, Sulistiyati Bayu Utami, Einosuke Mizuta, Kensaku Yamada, Osamu Igawa, Chiaki Shigemasa, Haruaki Ninomiya, Takuya Tsuchihashi, Ichiro Hisatome

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Both an angiotensin II receptor blocker, losartan (CAS 124750-99-8) and a serum urate lowering agent, benzbromarone (CAS 3562-84-3) exert a uricosuric action by inhibiting urate transporter 1 (URAT1). A recent clinical trial indicated that losartan could reduce the level of serumurate in hypertensive patients treated with urate lowering agents, suggesting the different mode of action of losartan from benzbromarone. In the present study, the effect of losartan and benzbromarone on the level of URAT1 mRNA was determined in transfected HEK293 cells. Losartan caused a significant reduction of its mRNA level, whereas it was not affected by benzbromarone. These results indicate that losartan decreases the level of human URAT1 mRNA, which may underlie the uricosuric action of losartan in hypertensive patients treated with serumurate lowering agents.

Original language	English
Pages (from-to)	186-188
Number of pages	3
Journal	Arzneimittel-Forschung/Drug Research
Volume	60
Issue number	4
DOIs	https://doi.org/10.1055/s-0031-1296271
State	Published - 2010
Externally published	Yes

Keywords

Benzbromarone
CAS 124750-99-8
CAS 3562-84-3
Human urate transporter 1 mRNA
Losartan

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10.1055/s-0031-1296271

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Nindita, Y., Hamada, T., Bahrudin, U., Hosoyamada, M., Ichida, K., Iwai, C., Urashima, S., Kuwabara, N., Utami, S. B., Mizuta, E., Yamada, K., Igawa, O., Shigemasa, C., Ninomiya, H., Tsuchihashi, T., & Hisatome, I. (2010). Effect of losartan and benzbromarone on the level of human urate transporter 1 mRNA. Arzneimittel-Forschung/Drug Research, 60(4), 186-188. https://doi.org/10.1055/s-0031-1296271

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title = "Effect of losartan and benzbromarone on the level of human urate transporter 1 mRNA",

abstract = "Both an angiotensin II receptor blocker, losartan (CAS 124750-99-8) and a serum urate lowering agent, benzbromarone (CAS 3562-84-3) exert a uricosuric action by inhibiting urate transporter 1 (URAT1). A recent clinical trial indicated that losartan could reduce the level of serumurate in hypertensive patients treated with urate lowering agents, suggesting the different mode of action of losartan from benzbromarone. In the present study, the effect of losartan and benzbromarone on the level of URAT1 mRNA was determined in transfected HEK293 cells. Losartan caused a significant reduction of its mRNA level, whereas it was not affected by benzbromarone. These results indicate that losartan decreases the level of human URAT1 mRNA, which may underlie the uricosuric action of losartan in hypertensive patients treated with serumurate lowering agents.",

keywords = "Benzbromarone, CAS 124750-99-8, CAS 3562-84-3, Human urate transporter 1 mRNA, Losartan",

author = "Yora Nindita and Toshihiro Hamada and Udin Bahrudin and Makoto Hosoyamada and Kimiyoshi Ichida and Chisato Iwai and Sunao Urashima and Narimasa Kuwabara and Utami, {Sulistiyati Bayu} and Einosuke Mizuta and Kensaku Yamada and Osamu Igawa and Chiaki Shigemasa and Haruaki Ninomiya and Takuya Tsuchihashi and Ichiro Hisatome",

year = "2010",

doi = "10.1055/s-0031-1296271",

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Nindita, Y, Hamada, T, Bahrudin, U, Hosoyamada, M, Ichida, K, Iwai, C, Urashima, S, Kuwabara, N, Utami, SB, Mizuta, E, Yamada, K, Igawa, O, Shigemasa, C, Ninomiya, H, Tsuchihashi, T & Hisatome, I 2010, 'Effect of losartan and benzbromarone on the level of human urate transporter 1 mRNA', Arzneimittel-Forschung/Drug Research, vol. 60, no. 4, pp. 186-188. https://doi.org/10.1055/s-0031-1296271

TY - JOUR

T1 - Effect of losartan and benzbromarone on the level of human urate transporter 1 mRNA

AU - Nindita, Yora

AU - Hamada, Toshihiro

AU - Bahrudin, Udin

AU - Hosoyamada, Makoto

AU - Ichida, Kimiyoshi

AU - Iwai, Chisato

AU - Urashima, Sunao

AU - Kuwabara, Narimasa

AU - Utami, Sulistiyati Bayu

AU - Mizuta, Einosuke

AU - Yamada, Kensaku

AU - Igawa, Osamu

AU - Shigemasa, Chiaki

AU - Ninomiya, Haruaki

AU - Tsuchihashi, Takuya

AU - Hisatome, Ichiro

PY - 2010

Y1 - 2010

N2 - Both an angiotensin II receptor blocker, losartan (CAS 124750-99-8) and a serum urate lowering agent, benzbromarone (CAS 3562-84-3) exert a uricosuric action by inhibiting urate transporter 1 (URAT1). A recent clinical trial indicated that losartan could reduce the level of serumurate in hypertensive patients treated with urate lowering agents, suggesting the different mode of action of losartan from benzbromarone. In the present study, the effect of losartan and benzbromarone on the level of URAT1 mRNA was determined in transfected HEK293 cells. Losartan caused a significant reduction of its mRNA level, whereas it was not affected by benzbromarone. These results indicate that losartan decreases the level of human URAT1 mRNA, which may underlie the uricosuric action of losartan in hypertensive patients treated with serumurate lowering agents.

AB - Both an angiotensin II receptor blocker, losartan (CAS 124750-99-8) and a serum urate lowering agent, benzbromarone (CAS 3562-84-3) exert a uricosuric action by inhibiting urate transporter 1 (URAT1). A recent clinical trial indicated that losartan could reduce the level of serumurate in hypertensive patients treated with urate lowering agents, suggesting the different mode of action of losartan from benzbromarone. In the present study, the effect of losartan and benzbromarone on the level of URAT1 mRNA was determined in transfected HEK293 cells. Losartan caused a significant reduction of its mRNA level, whereas it was not affected by benzbromarone. These results indicate that losartan decreases the level of human URAT1 mRNA, which may underlie the uricosuric action of losartan in hypertensive patients treated with serumurate lowering agents.

KW - Benzbromarone

KW - CAS 124750-99-8

KW - CAS 3562-84-3

KW - Human urate transporter 1 mRNA

KW - Losartan

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SN - 0004-4172

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SP - 186

EP - 188

JO - Arzneimittel-Forschung/Drug Research

JF - Arzneimittel-Forschung/Drug Research

IS - 4

ER -

Effect of losartan and benzbromarone on the level of human urate transporter 1 mRNA

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