TY - JOUR
T1 - Effect of ABO blood group incompatibility on the outcome of single-unit cord blood transplantation after myeloablative conditioning
AU - Konuma, Takaaki
AU - Kato, Seiko
AU - Ooi, Jun
AU - Oiwa-Monna, Maki
AU - Ebihara, Yasuhiro
AU - Mochizuki, Shinji
AU - Yuji, Koichiro
AU - Ohno, Nobuhiro
AU - Kawamata, Toyotaka
AU - Jo, Norihide
AU - Yokoyama, Kazuaki
AU - Uchimaru, Kaoru
AU - Tojo, Arinobu
AU - Takahashi, Satoshi
PY - 2014/4
Y1 - 2014/4
N2 - ABO blood group incompatibility between donor and recipient has been associated with poor transplant outcomes in allogeneic hematopoietic stem cell transplantation. However, its effect on the outcome of cord blood transplantation (CBT) has yet to be clarified. We retrospectively analyzed 191 adult patients who received single-unit CBT after myeloablative conditioning for malignant disease in our institute. Major mismatch showed a significantly lower incidence of platelet engraftment compared with ABO match as a reference (hazard ratio, .57; P=.01). Nevertheless, there was no increase in graft-versus-host disease, transplant-related mortality, and overall mortality after ABO-incompatible CBT. These data suggested that donor-recipient ABO incompatibility does not have a significant impact on outcome after myeloablative CBT for hematological malignancies.
AB - ABO blood group incompatibility between donor and recipient has been associated with poor transplant outcomes in allogeneic hematopoietic stem cell transplantation. However, its effect on the outcome of cord blood transplantation (CBT) has yet to be clarified. We retrospectively analyzed 191 adult patients who received single-unit CBT after myeloablative conditioning for malignant disease in our institute. Major mismatch showed a significantly lower incidence of platelet engraftment compared with ABO match as a reference (hazard ratio, .57; P=.01). Nevertheless, there was no increase in graft-versus-host disease, transplant-related mortality, and overall mortality after ABO-incompatible CBT. These data suggested that donor-recipient ABO incompatibility does not have a significant impact on outcome after myeloablative CBT for hematological malignancies.
KW - ABO incompatibility
KW - Cord blood transplantation
KW - Graft-versus-host disease
KW - Myeloablative conditioning
UR - http://www.scopus.com/inward/record.url?scp=84895781599&partnerID=8YFLogxK
U2 - 10.1016/j.bbmt.2013.12.563
DO - 10.1016/j.bbmt.2013.12.563
M3 - 記事
C2 - 24368297
AN - SCOPUS:84895781599
SN - 1083-8791
VL - 20
SP - 577
EP - 581
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
IS - 4
ER -