Development and progression of diabetic retinopathy in patients with Type 1 diabetes who are positive for GAD autoantibody

T. Mimura; H. Funatsu; Y. Uchigata; S. Kitano; E. Shimizu; H. Noma; S. Amano; M. Araie; Y. Iwamoto; S. Hori

doi:10.1111/j.1464-5491.2004.01204.x

Development and progression of diabetic retinopathy in patients with Type 1 diabetes who are positive for GAD autoantibody

T. Mimura, H. Funatsu, Y. Uchigata, S. Kitano, E. Shimizu, H. Noma, S. Amano, M. Araie, Y. Iwamoto, S. Hori

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Aims: To investigate the relationship between autoantibodies to glutamic acid decarboxylase (GAD) and proliferative diabetic retinopathy (PDR) to assess the role of autoimmunity in retinopathy. Methods: Patients with Type 1 diabetes for more than 10 years who had been diagnosed under age 30 (13-28 years) were studied. They were classified into three groups. The PDR group consisted of 22 patients, the pre-PDR group was 26 patients, while the non-DR group was 32 patients who had Type 1 diabetes without retinopathy. Blood was collected to measure autoantibodies to GAD, and the relationship between PDR and GAD positivity was investigated in a cross-sectional study. Results: The highest positivity rate of GAD autoantibodies was 50.0% in the non-DR group, followed by the pre-PDR group (30.8%) and the PDR group (18.2%). Conclusions: Production or existence of GAD autoantibodies may contribute to the prevention of retinopathy.

Original language	English
Pages (from-to)	559-562
Number of pages	4
Journal	Diabetic Medicine
Volume	21
Issue number	6
DOIs	https://doi.org/10.1111/j.1464-5491.2004.01204.x
State	Published - Jun 2004
Externally published	Yes

Keywords

Autoantibodies to glutamic acid decarboxylase
Glutamic acid decarboxylase autoantibodies
Proliferative diabetic retinopathy
Younger-onset Type 1 diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/j.1464-5491.2004.01204.x

Cite this

@article{3173321f31c04fd68623cb44562dcdf9,

title = "Development and progression of diabetic retinopathy in patients with Type 1 diabetes who are positive for GAD autoantibody",

abstract = "Aims: To investigate the relationship between autoantibodies to glutamic acid decarboxylase (GAD) and proliferative diabetic retinopathy (PDR) to assess the role of autoimmunity in retinopathy. Methods: Patients with Type 1 diabetes for more than 10 years who had been diagnosed under age 30 (13-28 years) were studied. They were classified into three groups. The PDR group consisted of 22 patients, the pre-PDR group was 26 patients, while the non-DR group was 32 patients who had Type 1 diabetes without retinopathy. Blood was collected to measure autoantibodies to GAD, and the relationship between PDR and GAD positivity was investigated in a cross-sectional study. Results: The highest positivity rate of GAD autoantibodies was 50.0\% in the non-DR group, followed by the pre-PDR group (30.8\%) and the PDR group (18.2\%). Conclusions: Production or existence of GAD autoantibodies may contribute to the prevention of retinopathy.",

keywords = "Autoantibodies to glutamic acid decarboxylase, Glutamic acid decarboxylase autoantibodies, Proliferative diabetic retinopathy, Younger-onset Type 1 diabetes",

author = "T. Mimura and H. Funatsu and Y. Uchigata and S. Kitano and E. Shimizu and H. Noma and S. Amano and M. Araie and Y. Iwamoto and S. Hori",

year = "2004",

month = jun,

doi = "10.1111/j.1464-5491.2004.01204.x",

language = "英語",

volume = "21",

pages = "559--562",

journal = "Diabetic Medicine",

issn = "0742-3071",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "6",

}

TY - JOUR

T1 - Development and progression of diabetic retinopathy in patients with Type 1 diabetes who are positive for GAD autoantibody

AU - Mimura, T.

AU - Funatsu, H.

AU - Uchigata, Y.

AU - Kitano, S.

AU - Shimizu, E.

AU - Noma, H.

AU - Amano, S.

AU - Araie, M.

AU - Iwamoto, Y.

AU - Hori, S.

PY - 2004/6

Y1 - 2004/6

N2 - Aims: To investigate the relationship between autoantibodies to glutamic acid decarboxylase (GAD) and proliferative diabetic retinopathy (PDR) to assess the role of autoimmunity in retinopathy. Methods: Patients with Type 1 diabetes for more than 10 years who had been diagnosed under age 30 (13-28 years) were studied. They were classified into three groups. The PDR group consisted of 22 patients, the pre-PDR group was 26 patients, while the non-DR group was 32 patients who had Type 1 diabetes without retinopathy. Blood was collected to measure autoantibodies to GAD, and the relationship between PDR and GAD positivity was investigated in a cross-sectional study. Results: The highest positivity rate of GAD autoantibodies was 50.0% in the non-DR group, followed by the pre-PDR group (30.8%) and the PDR group (18.2%). Conclusions: Production or existence of GAD autoantibodies may contribute to the prevention of retinopathy.

AB - Aims: To investigate the relationship between autoantibodies to glutamic acid decarboxylase (GAD) and proliferative diabetic retinopathy (PDR) to assess the role of autoimmunity in retinopathy. Methods: Patients with Type 1 diabetes for more than 10 years who had been diagnosed under age 30 (13-28 years) were studied. They were classified into three groups. The PDR group consisted of 22 patients, the pre-PDR group was 26 patients, while the non-DR group was 32 patients who had Type 1 diabetes without retinopathy. Blood was collected to measure autoantibodies to GAD, and the relationship between PDR and GAD positivity was investigated in a cross-sectional study. Results: The highest positivity rate of GAD autoantibodies was 50.0% in the non-DR group, followed by the pre-PDR group (30.8%) and the PDR group (18.2%). Conclusions: Production or existence of GAD autoantibodies may contribute to the prevention of retinopathy.

KW - Autoantibodies to glutamic acid decarboxylase

KW - Glutamic acid decarboxylase autoantibodies

KW - Proliferative diabetic retinopathy

KW - Younger-onset Type 1 diabetes

UR - https://www.scopus.com/pages/publications/2942517501

U2 - 10.1111/j.1464-5491.2004.01204.x

DO - 10.1111/j.1464-5491.2004.01204.x

M3 - 記事

C2 - 15154939

AN - SCOPUS:2942517501

SN - 0742-3071

VL - 21

SP - 559

EP - 562

JO - Diabetic Medicine

JF - Diabetic Medicine

IS - 6

ER -

Development and progression of diabetic retinopathy in patients with Type 1 diabetes who are positive for GAD autoantibody

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this