TY - JOUR
T1 - Cytokine storm in acute pancreatitis
T2 - Influence of inflammatory attack and arterial infusion therapy
AU - Sugimoto, Maki
AU - Takada, Tadahiro
AU - Yasuda, Hideki
AU - Amano, Hodaka
AU - Yoshida, Masahiro
AU - Isaka, Takahiro
AU - Toyota, Naoyuki
AU - Wada, Keita
AU - Takagi, Kenji
PY - 2003/8/1
Y1 - 2003/8/1
N2 - Purpose: This study was designed to clarify the change of the cytokine levels in acute pancreatitis (AP), and investigate the concern over the cytokine storm in AP with its course of inflammatory attack, as well as the effect of continuous arterial infusion therapy (CAI). Subjects and methods: Twenty-seven patients with AP were subjected during latest 3 years. The serum cytokines were determined before and after the treatment. Results: (1) In all subjects, high levels pro-inflammatory cytokines (IL-6, IL-8) were observed at the day of admission. However, after receiving the intensive treatments, IL-6, IL-8 levels tended to decline. (2) According to the severity of AP, the levels of IL-6 and IL-8 in severe cases were significantly higher than those in moderate and mild cases. (3) In five severe cases with infections, renewed rising of serum IL-6 was observed. (4) Abnormally heightened IL-10 (anti-inflammatory cytokine) was observed in complicated cases with infections. (5) The serum IL-6 was decreased immediately in severe cases after CAI, more rapidly than those without CAI. Conclusions: High levels of cytokines resumed in most cases of AP; when inflammation occurred, cytokine storm was suddenly observed. These molecules appear to be valuable markers of severity and effects of CAI.
AB - Purpose: This study was designed to clarify the change of the cytokine levels in acute pancreatitis (AP), and investigate the concern over the cytokine storm in AP with its course of inflammatory attack, as well as the effect of continuous arterial infusion therapy (CAI). Subjects and methods: Twenty-seven patients with AP were subjected during latest 3 years. The serum cytokines were determined before and after the treatment. Results: (1) In all subjects, high levels pro-inflammatory cytokines (IL-6, IL-8) were observed at the day of admission. However, after receiving the intensive treatments, IL-6, IL-8 levels tended to decline. (2) According to the severity of AP, the levels of IL-6 and IL-8 in severe cases were significantly higher than those in moderate and mild cases. (3) In five severe cases with infections, renewed rising of serum IL-6 was observed. (4) Abnormally heightened IL-10 (anti-inflammatory cytokine) was observed in complicated cases with infections. (5) The serum IL-6 was decreased immediately in severe cases after CAI, more rapidly than those without CAI. Conclusions: High levels of cytokines resumed in most cases of AP; when inflammation occurred, cytokine storm was suddenly observed. These molecules appear to be valuable markers of severity and effects of CAI.
KW - Acute pancreatitis
KW - Continuous arterial infusion therapy (CAI)
KW - Cytokine storm
KW - Second attack
KW - Severity
UR - http://www.scopus.com/inward/record.url?scp=33644674113&partnerID=8YFLogxK
U2 - 10.1016/S0531-5131(03)00908-7
DO - 10.1016/S0531-5131(03)00908-7
M3 - 記事
AN - SCOPUS:33644674113
SN - 0531-5131
VL - 1255
SP - 183
EP - 186
JO - International Congress Series
JF - International Congress Series
IS - C
ER -