Computed tomography perfusion imaging as a potential imaging biomarker of colorectal cancer

Koichi Hayano; Takeshi Fujishiro; Dushyant V. Sahani; Asami Satoh; Tomoyoshi Aoyagi; Gaku Ohira; Toru Tochigi; Hisahiro Matsubara; Kiyohiko Shuto

doi:10.3748/wjg.v20.i46.17345

Computed tomography perfusion imaging as a potential imaging biomarker of colorectal cancer

Koichi Hayano, Takeshi Fujishiro, Dushyant V. Sahani, Asami Satoh, Tomoyoshi Aoyagi, Gaku Ohira, Toru Tochigi, Hisahiro Matsubara, Kiyohiko Shuto

School of Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Neovascularization was reported to arise early in the adenoma-carcinoma sequence in colorectal cancer (CRC), and the importance of angiogenesis in cancer progression has been established. Computed tomography (CT) perfusion (CTP) based on high temporal resolution CT images enables evaluation of hemodynamics of tissue in vivo by modeling tracer kinetics. CTP has been reported to characterize tumor angiogenesis, and to be a sensitive marker for predicting recurrence or survival in CRC. In this review, we will discuss the biomarker value of CTP in the management of CRC patients.

Original language	English
Pages (from-to)	17345-17351
Number of pages	7
Journal	World Journal of Gastroenterology
Volume	20
Issue number	46
DOIs	https://doi.org/10.3748/wjg.v20.i46.17345
State	Published - 14 Dec 2014

Keywords

Angiogenesis
Antiangiogenic therapy
Chemoradiation therapy
Colorectal cancer
Computed tomography perfusion

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3748/wjg.v20.i46.17345

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abstract = "Neovascularization was reported to arise early in the adenoma-carcinoma sequence in colorectal cancer (CRC), and the importance of angiogenesis in cancer progression has been established. Computed tomography (CT) perfusion (CTP) based on high temporal resolution CT images enables evaluation of hemodynamics of tissue in vivo by modeling tracer kinetics. CTP has been reported to characterize tumor angiogenesis, and to be a sensitive marker for predicting recurrence or survival in CRC. In this review, we will discuss the biomarker value of CTP in the management of CRC patients.",

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AU - Hayano, Koichi

AU - Fujishiro, Takeshi

AU - Sahani, Dushyant V.

AU - Satoh, Asami

AU - Aoyagi, Tomoyoshi

AU - Ohira, Gaku

AU - Tochigi, Toru

AU - Matsubara, Hisahiro

AU - Shuto, Kiyohiko

PY - 2014/12/14

Y1 - 2014/12/14

N2 - Neovascularization was reported to arise early in the adenoma-carcinoma sequence in colorectal cancer (CRC), and the importance of angiogenesis in cancer progression has been established. Computed tomography (CT) perfusion (CTP) based on high temporal resolution CT images enables evaluation of hemodynamics of tissue in vivo by modeling tracer kinetics. CTP has been reported to characterize tumor angiogenesis, and to be a sensitive marker for predicting recurrence or survival in CRC. In this review, we will discuss the biomarker value of CTP in the management of CRC patients.

AB - Neovascularization was reported to arise early in the adenoma-carcinoma sequence in colorectal cancer (CRC), and the importance of angiogenesis in cancer progression has been established. Computed tomography (CT) perfusion (CTP) based on high temporal resolution CT images enables evaluation of hemodynamics of tissue in vivo by modeling tracer kinetics. CTP has been reported to characterize tumor angiogenesis, and to be a sensitive marker for predicting recurrence or survival in CRC. In this review, we will discuss the biomarker value of CTP in the management of CRC patients.

KW - Angiogenesis

KW - Antiangiogenic therapy

KW - Chemoradiation therapy

KW - Colorectal cancer

KW - Computed tomography perfusion

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Computed tomography perfusion imaging as a potential imaging biomarker of colorectal cancer

Abstract

Keywords

UN SDGs

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