TY - JOUR
T1 - Clinical practice guideline for renal hypouricemia (1st edition)
AU - Nakayama, Akiyoshi
AU - Matsuo, Hirotaka
AU - Ohtahara, Akira
AU - Ogino, Kazuhide
AU - Hakoda, Masayuki
AU - Hamada, Toshihiro
AU - Hosoyamada, Makoto
AU - Yamaguchi, Satoshi
AU - Hisatome, Ichiro
AU - Ichida, Kimiyoshi
AU - Shinomiya, Nariyoshi
N1 - Publisher Copyright:
© 2019, The Author(s).
PY - 2019
Y1 - 2019
N2 - Renal hypouricemia (RHUC) is a disease caused by dysfunction of renal urate reabsorption transporters; however, diagnostic guidance and guidelines for RHUC have been lacking, partly due to the low evidence level of studies on RHUC. This review describes a world-first clinical practice guideline (CPG) and its first version in English for this condition. It was developed following the “MINDS Manual for Guideline Development” methodology, which prioritizes evidence-based medicine. It was published in Japanese in 2017 and later translated into English. The primary goal of this CPG is to clarify the criteria for diagnosing RHUC; another aim is to work towards a consensus on clinical decision-making. One of the CPG’s unique points is that it contains textbook descriptions at the expert consensus level, in addition to two clinical questions and recommendations derived from a systematic review of the literature. The guidance shown in this CPG makes it easy to diagnose RHUC from simple blood and urine tests. This CPG contains almost all of the clinical foci of RHUC: epidemiology, pathophysiology, diagnostic guidance, clinical examinations, differential diagnosis, and complications, including exercise-induced acute kidney injury and urolithiasis. A CPG summary as well as a clinical algorithm to assist healthcare providers with a quick reference and notes from an athlete for both physicians and patients are included. We hope that this CPG will help healthcare providers and patients to make clinical decisions, and that it will promote further research on RHUC.
AB - Renal hypouricemia (RHUC) is a disease caused by dysfunction of renal urate reabsorption transporters; however, diagnostic guidance and guidelines for RHUC have been lacking, partly due to the low evidence level of studies on RHUC. This review describes a world-first clinical practice guideline (CPG) and its first version in English for this condition. It was developed following the “MINDS Manual for Guideline Development” methodology, which prioritizes evidence-based medicine. It was published in Japanese in 2017 and later translated into English. The primary goal of this CPG is to clarify the criteria for diagnosing RHUC; another aim is to work towards a consensus on clinical decision-making. One of the CPG’s unique points is that it contains textbook descriptions at the expert consensus level, in addition to two clinical questions and recommendations derived from a systematic review of the literature. The guidance shown in this CPG makes it easy to diagnose RHUC from simple blood and urine tests. This CPG contains almost all of the clinical foci of RHUC: epidemiology, pathophysiology, diagnostic guidance, clinical examinations, differential diagnosis, and complications, including exercise-induced acute kidney injury and urolithiasis. A CPG summary as well as a clinical algorithm to assist healthcare providers with a quick reference and notes from an athlete for both physicians and patients are included. We hope that this CPG will help healthcare providers and patients to make clinical decisions, and that it will promote further research on RHUC.
KW - Acute renal failure with severe loin pain and patchy renal ischemia after anaerobic exercise (ALPE)
KW - Clinical practice guideline (CPG)
KW - Evidence-based medicine (EBM)
KW - Exercise-induced acute kidney injury (EIAKI)
KW - Renal hypouricemia (RHUC)
UR - http://www.scopus.com/inward/record.url?scp=85061838420&partnerID=8YFLogxK
U2 - 10.1007/s13577-019-00239-3
DO - 10.1007/s13577-019-00239-3
M3 - 総説
C2 - 30783949
AN - SCOPUS:85061838420
SN - 0914-7470
JO - Human Cell
JF - Human Cell
ER -