Clinical epidemiology and mortality on patients with acute respiratory distress syndrome (ARDS) in Vietnam

Luong Quoc Chinh; Toshie Manabe; Do Ngoc Son; Nguyen Van Chi; Yuji Fujikura; Nguyen Gia Binh; Dao Xuan Co; Dang Quoc Tuan; Mai Duy Ton; Khuong Quoc Dai; Pham The Thach; Hiroyuki Nagase; Koichiro Kudo; Dat Anh Nguyen

doi:10.1371/journal.pone.0221114

Clinical epidemiology and mortality on patients with acute respiratory distress syndrome (ARDS) in Vietnam

Luong Quoc Chinh
, Toshie Manabe
, Do Ngoc Son
, Nguyen Van Chi
, Yuji Fujikura
, Nguyen Gia Binh
, Dao Xuan Co
, Dang Quoc Tuan
, Mai Duy Ton
, Khuong Quoc Dai
, Pham The Thach
, Hiroyuki Nagase
, Koichiro Kudo
, Dat Anh Nguyen

School of Medicine

Bach Mai Hospital
Jichi Medical University
National Defense Medical College Tokorozawa
Hanoi Medical University
Yurin Hospital
Waseda University

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Background The clinical epidemiology and disease prognosis in patients with acute respiratory distress syndrome (ARDS) have not yet been fully elucidated in Vietnam. Methods We conducted a retrospective observational study at a national tertiary hospital in Hanoi, Vietnam. Participants were adult patients (age 18 years) who were admitted and diagnosed with ARDS during 2015–2017. Data on patients’ general and clinical conditions, radiographic findings, ventilator settings, gas exchange, and treatment methods were collected and compared between survivors and non-survivors. Risk factors for mortality were assessed using logistic regression analysis. Results Among 126 eligible patients with ARDS admitted to the central tertiary hospital in Vietnam, we observed high mortality (57.1%). Of the total patients, 91.3% were transferred from local hospitals with a diagnosis of severe pneumonia and then diagnosed with ARDS at the central hospital. At the time of admission, 53.2% of patients had severe ARDS, 37.3% had moderate ARDS, and 9.5% had mild ARDS. The mean (standard deviation) sequential organ failure assessment (SOFA) score was 9.5 (3.4) in non-survivors and 7.4 (3.4) in survivors (p = 0.002). Although there was no significant difference in PaO₂/FiO₂ on admission between non-survivors and survivors, that on day 3 after admission was significantly different (p = 0.002). Logistic regression revealed that PaO₂/FiO₂ on day 3 [odds ratio (OR), 1.010; 95% confidence interval (CI), 1.003–1.017], length of stay in a local hospital before admission to the central hospital (OR, 1.122; 95% CI, 1.042–1.210) due to stable condition, and SOFA score on Day 1 (OR, 0.842; 95% CI, 0.708–1.002) were independent factors in patient survival. Conclusions Patients with ARDS admitted the central tertiary hospital had severe illness and high mortality. Most patients were transferred from local hospitals. Improvements in human, medical, and sociological resources in local will contribute to reducing the mortality of ARDS in Vietnam.

Original language	English
Article number	e0221114
Journal	PLOS ONE
Volume	14
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0221114
State	Published - 1 Aug 2019

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10.1371/journal.pone.0221114

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Chinh, L. Q., Manabe, T., Son, D. N., Van Chi, N., Fujikura, Y., Binh, N. G., Co, D. X., Tuan, D. Q., Ton, M. D., Dai, K. Q., Thach, P. T., Nagase, H., Kudo, K., & Nguyen, D. A. (2019). Clinical epidemiology and mortality on patients with acute respiratory distress syndrome (ARDS) in Vietnam. PLOS ONE, 14(8), Article e0221114. https://doi.org/10.1371/journal.pone.0221114

@article{fc7e1ae335344ea0b2c74921ba3366f3,

title = "Clinical epidemiology and mortality on patients with acute respiratory distress syndrome (ARDS) in Vietnam",

abstract = "Background The clinical epidemiology and disease prognosis in patients with acute respiratory distress syndrome (ARDS) have not yet been fully elucidated in Vietnam. Methods We conducted a retrospective observational study at a national tertiary hospital in Hanoi, Vietnam. Participants were adult patients (age 18 years) who were admitted and diagnosed with ARDS during 2015–2017. Data on patients{\textquoteright} general and clinical conditions, radiographic findings, ventilator settings, gas exchange, and treatment methods were collected and compared between survivors and non-survivors. Risk factors for mortality were assessed using logistic regression analysis. Results Among 126 eligible patients with ARDS admitted to the central tertiary hospital in Vietnam, we observed high mortality (57.1\%). Of the total patients, 91.3\% were transferred from local hospitals with a diagnosis of severe pneumonia and then diagnosed with ARDS at the central hospital. At the time of admission, 53.2\% of patients had severe ARDS, 37.3\% had moderate ARDS, and 9.5\% had mild ARDS. The mean (standard deviation) sequential organ failure assessment (SOFA) score was 9.5 (3.4) in non-survivors and 7.4 (3.4) in survivors (p = 0.002). Although there was no significant difference in PaO2/FiO2 on admission between non-survivors and survivors, that on day 3 after admission was significantly different (p = 0.002). Logistic regression revealed that PaO2/FiO2 on day 3 [odds ratio (OR), 1.010; 95\% confidence interval (CI), 1.003–1.017], length of stay in a local hospital before admission to the central hospital (OR, 1.122; 95\% CI, 1.042–1.210) due to stable condition, and SOFA score on Day 1 (OR, 0.842; 95\% CI, 0.708–1.002) were independent factors in patient survival. Conclusions Patients with ARDS admitted the central tertiary hospital had severe illness and high mortality. Most patients were transferred from local hospitals. Improvements in human, medical, and sociological resources in local will contribute to reducing the mortality of ARDS in Vietnam.",

author = "Chinh, \{Luong Quoc\} and Toshie Manabe and Son, \{Do Ngoc\} and \{Van Chi\}, Nguyen and Yuji Fujikura and Binh, \{Nguyen Gia\} and Co, \{Dao Xuan\} and Tuan, \{Dang Quoc\} and Ton, \{Mai Duy\} and Dai, \{Khuong Quoc\} and Thach, \{Pham The\} and Hiroyuki Nagase and Koichiro Kudo and Nguyen, \{Dat Anh\}",

note = "Publisher Copyright: {\textcopyright} 2019 Chinh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2019",

month = aug,

day = "1",

doi = "10.1371/journal.pone.0221114",

language = "英語",

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T1 - Clinical epidemiology and mortality on patients with acute respiratory distress syndrome (ARDS) in Vietnam

AU - Chinh, Luong Quoc

AU - Manabe, Toshie

AU - Son, Do Ngoc

AU - Van Chi, Nguyen

AU - Fujikura, Yuji

AU - Binh, Nguyen Gia

AU - Co, Dao Xuan

AU - Tuan, Dang Quoc

AU - Ton, Mai Duy

AU - Dai, Khuong Quoc

AU - Thach, Pham The

AU - Nagase, Hiroyuki

AU - Kudo, Koichiro

AU - Nguyen, Dat Anh

N1 - Publisher Copyright: © 2019 Chinh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Background The clinical epidemiology and disease prognosis in patients with acute respiratory distress syndrome (ARDS) have not yet been fully elucidated in Vietnam. Methods We conducted a retrospective observational study at a national tertiary hospital in Hanoi, Vietnam. Participants were adult patients (age 18 years) who were admitted and diagnosed with ARDS during 2015–2017. Data on patients’ general and clinical conditions, radiographic findings, ventilator settings, gas exchange, and treatment methods were collected and compared between survivors and non-survivors. Risk factors for mortality were assessed using logistic regression analysis. Results Among 126 eligible patients with ARDS admitted to the central tertiary hospital in Vietnam, we observed high mortality (57.1%). Of the total patients, 91.3% were transferred from local hospitals with a diagnosis of severe pneumonia and then diagnosed with ARDS at the central hospital. At the time of admission, 53.2% of patients had severe ARDS, 37.3% had moderate ARDS, and 9.5% had mild ARDS. The mean (standard deviation) sequential organ failure assessment (SOFA) score was 9.5 (3.4) in non-survivors and 7.4 (3.4) in survivors (p = 0.002). Although there was no significant difference in PaO2/FiO2 on admission between non-survivors and survivors, that on day 3 after admission was significantly different (p = 0.002). Logistic regression revealed that PaO2/FiO2 on day 3 [odds ratio (OR), 1.010; 95% confidence interval (CI), 1.003–1.017], length of stay in a local hospital before admission to the central hospital (OR, 1.122; 95% CI, 1.042–1.210) due to stable condition, and SOFA score on Day 1 (OR, 0.842; 95% CI, 0.708–1.002) were independent factors in patient survival. Conclusions Patients with ARDS admitted the central tertiary hospital had severe illness and high mortality. Most patients were transferred from local hospitals. Improvements in human, medical, and sociological resources in local will contribute to reducing the mortality of ARDS in Vietnam.

AB - Background The clinical epidemiology and disease prognosis in patients with acute respiratory distress syndrome (ARDS) have not yet been fully elucidated in Vietnam. Methods We conducted a retrospective observational study at a national tertiary hospital in Hanoi, Vietnam. Participants were adult patients (age 18 years) who were admitted and diagnosed with ARDS during 2015–2017. Data on patients’ general and clinical conditions, radiographic findings, ventilator settings, gas exchange, and treatment methods were collected and compared between survivors and non-survivors. Risk factors for mortality were assessed using logistic regression analysis. Results Among 126 eligible patients with ARDS admitted to the central tertiary hospital in Vietnam, we observed high mortality (57.1%). Of the total patients, 91.3% were transferred from local hospitals with a diagnosis of severe pneumonia and then diagnosed with ARDS at the central hospital. At the time of admission, 53.2% of patients had severe ARDS, 37.3% had moderate ARDS, and 9.5% had mild ARDS. The mean (standard deviation) sequential organ failure assessment (SOFA) score was 9.5 (3.4) in non-survivors and 7.4 (3.4) in survivors (p = 0.002). Although there was no significant difference in PaO2/FiO2 on admission between non-survivors and survivors, that on day 3 after admission was significantly different (p = 0.002). Logistic regression revealed that PaO2/FiO2 on day 3 [odds ratio (OR), 1.010; 95% confidence interval (CI), 1.003–1.017], length of stay in a local hospital before admission to the central hospital (OR, 1.122; 95% CI, 1.042–1.210) due to stable condition, and SOFA score on Day 1 (OR, 0.842; 95% CI, 0.708–1.002) were independent factors in patient survival. Conclusions Patients with ARDS admitted the central tertiary hospital had severe illness and high mortality. Most patients were transferred from local hospitals. Improvements in human, medical, and sociological resources in local will contribute to reducing the mortality of ARDS in Vietnam.

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DO - 10.1371/journal.pone.0221114

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C2 - 31415662

AN - SCOPUS:85070756033

SN - 1932-6203

VL - 14

JO - PLOS ONE

JF - PLOS ONE

IS - 8

M1 - e0221114

ER -

Clinical epidemiology and mortality on patients with acute respiratory distress syndrome (ARDS) in Vietnam

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