Byelyankacin: A novel melanogenesis inhibitor produced by Enterobacter sp. B20

Senji Takahashi; Hiroki Iwai; Kunio Kosaka; Toshitsugu Miyazaki; Yuko Osanai; Nakako Arao; Kouichi Tanaka; Koji Nagai; Akira Nakagawa

doi:10.1038/ja.2007.93

Byelyankacin: A novel melanogenesis inhibitor produced by Enterobacter sp. B20

Senji Takahashi, Hiroki Iwai, Kunio Kosaka, Toshitsugu Miyazaki, Yuko Osanai, Nakako Arao, Kouichi Tanaka, Koji Nagai, Akira Nakagawa

Faculty of Science and Engineering

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A novel melanogenesis inhibitor, byelyankacin (1), was isolated from the fermentation broth of a bacterial strain. The producing organism, designated B20, was identified as a member of the genus Enterobacter based on taxonomic characteristics. 1 was obtained as a white powder from the culture medium by solvent extraction and serial chromatographic purification. The structure of 1 was determined as (E)-4-(2-isocyanovinyl)phenyl α-L-rhamnopyranoside on the basis of spectroscopic data. 1 potently inhibited mushroom tyrosinase and melanogenesis of B16-2D2 melanoma cells with IC₅₀ value of 2.1 nM and 30 nM, respectively.

Original language	English
Pages (from-to)	717-720
Number of pages	4
Journal	Journal of Antibiotics
Volume	60
Issue number	11
DOIs	https://doi.org/10.1038/ja.2007.93
State	Published - Nov 2007

Keywords

B16-2D2 melanoma cell
Byelyankacin
Enterobacter sp.
Melanogenesis inhibitor
Mushroom tyrosinase

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ja.2007.93

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title = "Byelyankacin: A novel melanogenesis inhibitor produced by Enterobacter sp. B20",

abstract = "A novel melanogenesis inhibitor, byelyankacin (1), was isolated from the fermentation broth of a bacterial strain. The producing organism, designated B20, was identified as a member of the genus Enterobacter based on taxonomic characteristics. 1 was obtained as a white powder from the culture medium by solvent extraction and serial chromatographic purification. The structure of 1 was determined as (E)-4-(2-isocyanovinyl)phenyl α-L-rhamnopyranoside on the basis of spectroscopic data. 1 potently inhibited mushroom tyrosinase and melanogenesis of B16-2D2 melanoma cells with IC50 value of 2.1 nM and 30 nM, respectively.",

keywords = "B16-2D2 melanoma cell, Byelyankacin, Enterobacter sp., Melanogenesis inhibitor, Mushroom tyrosinase",

author = "Senji Takahashi and Hiroki Iwai and Kunio Kosaka and Toshitsugu Miyazaki and Yuko Osanai and Nakako Arao and Kouichi Tanaka and Koji Nagai and Akira Nakagawa",

year = "2007",

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doi = "10.1038/ja.2007.93",

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volume = "60",

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T2 - A novel melanogenesis inhibitor produced by Enterobacter sp. B20

AU - Takahashi, Senji

AU - Iwai, Hiroki

AU - Kosaka, Kunio

AU - Miyazaki, Toshitsugu

AU - Osanai, Yuko

AU - Arao, Nakako

AU - Tanaka, Kouichi

AU - Nagai, Koji

AU - Nakagawa, Akira

PY - 2007/11

Y1 - 2007/11

N2 - A novel melanogenesis inhibitor, byelyankacin (1), was isolated from the fermentation broth of a bacterial strain. The producing organism, designated B20, was identified as a member of the genus Enterobacter based on taxonomic characteristics. 1 was obtained as a white powder from the culture medium by solvent extraction and serial chromatographic purification. The structure of 1 was determined as (E)-4-(2-isocyanovinyl)phenyl α-L-rhamnopyranoside on the basis of spectroscopic data. 1 potently inhibited mushroom tyrosinase and melanogenesis of B16-2D2 melanoma cells with IC50 value of 2.1 nM and 30 nM, respectively.

AB - A novel melanogenesis inhibitor, byelyankacin (1), was isolated from the fermentation broth of a bacterial strain. The producing organism, designated B20, was identified as a member of the genus Enterobacter based on taxonomic characteristics. 1 was obtained as a white powder from the culture medium by solvent extraction and serial chromatographic purification. The structure of 1 was determined as (E)-4-(2-isocyanovinyl)phenyl α-L-rhamnopyranoside on the basis of spectroscopic data. 1 potently inhibited mushroom tyrosinase and melanogenesis of B16-2D2 melanoma cells with IC50 value of 2.1 nM and 30 nM, respectively.

KW - B16-2D2 melanoma cell

KW - Byelyankacin

KW - Enterobacter sp.

KW - Melanogenesis inhibitor

KW - Mushroom tyrosinase

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DO - 10.1038/ja.2007.93

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Byelyankacin: A novel melanogenesis inhibitor produced by Enterobacter sp. B20

Abstract

Keywords

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