TY - JOUR
T1 - Antisulfatide antibody in patients with chronic hepatitis C
T2 - its prevalence and clinical features of patients with the antibody
AU - Hashimoto, Naoaki
AU - Kashiwagi, Masuo
AU - Ikeda, Yusei
AU - Han, Katsuken
AU - Yamada, Haruki
AU - Maruyama, Toshiyuki
AU - Tanaka, Atsushi
AU - Kurokawa, Kiyoshi
AU - Toda, Gotaro
PY - 1994/11/1
Y1 - 1994/11/1
N2 - We investigated the prevalence of antisulfatide antibody, an antibody found in sera from patients with autoimmune hepatitis (AIH) type 1, in sera from 39 patients with chronic hepatitis C (CHC). The antibody was examined by enzyme-linked immunosorbent assay as reported previously and was detected in three cases (7.7%). These three patients were included in 18 patients carrying antinuclear antibody (ANA), measured using HEp-2 cell monolayers, and also included in 15 patients whose serum IgG concentration was over 2000 mg/100 ml. Antisulfatide antibody did not occur in 21 patients who were negative for ANA. On the contrary, antisulfatide antibody was detected in 22 of 24 patients (91.7%) with AIH type 1 whose markers of hepatitis virus C and B infection were negative. In conclusion, antisulfatide antibody was rare, but did occur in patients with CHC. This provides a clue for resolving autoimmune phenomena in patients with CHC.
AB - We investigated the prevalence of antisulfatide antibody, an antibody found in sera from patients with autoimmune hepatitis (AIH) type 1, in sera from 39 patients with chronic hepatitis C (CHC). The antibody was examined by enzyme-linked immunosorbent assay as reported previously and was detected in three cases (7.7%). These three patients were included in 18 patients carrying antinuclear antibody (ANA), measured using HEp-2 cell monolayers, and also included in 15 patients whose serum IgG concentration was over 2000 mg/100 ml. Antisulfatide antibody did not occur in 21 patients who were negative for ANA. On the contrary, antisulfatide antibody was detected in 22 of 24 patients (91.7%) with AIH type 1 whose markers of hepatitis virus C and B infection were negative. In conclusion, antisulfatide antibody was rare, but did occur in patients with CHC. This provides a clue for resolving autoimmune phenomena in patients with CHC.
KW - Antinuclear antibody
KW - Antisulfatide antibody
KW - Autoimmune hepatitis
KW - Chronic hepatitis
KW - Hepatitis C virus
UR - http://www.scopus.com/inward/record.url?scp=0028099163&partnerID=8YFLogxK
U2 - 10.1016/0928-4346(94)90038-8
DO - 10.1016/0928-4346(94)90038-8
M3 - 記事
AN - SCOPUS:0028099163
SN - 0928-4346
VL - 2
SP - 388
EP - 392
JO - International Hepatology Communications
JF - International Hepatology Communications
IS - 6
ER -
