Antifungal susceptibility of Japanese isolates of Nannizia fulva (Formerly Microsporum fulvum)

Human and animal dermatophytoses are most commonly treated with systemic antifungal drugs such as itraconazole (ITZ) and terbinafine (TRF). The antifungal susceptibility of Nannizia fulva, however, remains poorly documented. In the present study, we investigated the in vitro susceptibility of N. fulva to ITZ and TRFusing the CLSI M38-A2 test. The mean MICs for the 12 tested strains were 0.6542 mg/L (range: 0.0625-1 mg/L) for ITZ and 0.15625 mg/L (range: < 0.003125-0.5 mg/L) for TRF. These results indicate that ITZ and TRFat standard veterinary doses should be efficacious against N. fulva.