Antifungal drugs-low-susceptibility in aspergillus flavus isolated from a captively reared okinawa rail (Hypotaenidia okinawae)

Rui Kano; Meika Tsunoi; Yumiko Nakaya; Takashi Nagamine; Koji Ono

doi:10.1292/jvms.20-0380

Antifungal drugs-low-susceptibility in aspergillus flavus isolated from a captively reared okinawa rail (Hypotaenidia okinawae)

Rui Kano
, Meika Tsunoi
, Yumiko Nakaya
, Takashi Nagamine
, Koji Ono

Research output: Contribution to journal › Comment/debate

4 Scopus citations

Abstract

A four-month old female Okinawa rail (Hypotaenidia okinawae) presented with respiratory distress. Despite antifungal treatment with voriconazole (VRZ), micafungin (MCF), and itraconazole (ITZ), respiratory distress did not improve and the bird died 167 days after initiating treatment. Necropsy revealed multifocal pyogranulomatous necrotic nodular lesions with numerous whitish-green fungal hyphae in the left air sac. Aspergillus flavus was isolated from the left air sac lesion. Antifungal susceptibility tests indicated that the isolate showed low susceptibility to amphotericin B (AMB), fluconazole (FLZ), VRZ and MCF.

Original language	English
Pages (from-to)	28-30
Number of pages	3
Journal	Journal of Veterinary Medical Science
Volume	83
Issue number	1
DOIs	https://doi.org/10.1292/jvms.20-0380
State	Published - 2021
Externally published	Yes

Keywords

Antifungal susceptibility tests
Aspergillus flavus
Avian aspergillosis
Low-susceptibility
Okinawa rail

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10.1292/jvms.20-0380

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title = "Antifungal drugs-low-susceptibility in aspergillus flavus isolated from a captively reared okinawa rail (Hypotaenidia okinawae)",

abstract = "A four-month old female Okinawa rail (Hypotaenidia okinawae) presented with respiratory distress. Despite antifungal treatment with voriconazole (VRZ), micafungin (MCF), and itraconazole (ITZ), respiratory distress did not improve and the bird died 167 days after initiating treatment. Necropsy revealed multifocal pyogranulomatous necrotic nodular lesions with numerous whitish-green fungal hyphae in the left air sac. Aspergillus flavus was isolated from the left air sac lesion. Antifungal susceptibility tests indicated that the isolate showed low susceptibility to amphotericin B (AMB), fluconazole (FLZ), VRZ and MCF.",

keywords = "Antifungal susceptibility tests, Aspergillus flavus, Avian aspergillosis, Low-susceptibility, Okinawa rail",

author = "Rui Kano and Meika Tsunoi and Yumiko Nakaya and Takashi Nagamine and Koji Ono",

note = "Publisher Copyright: {\textcopyright} 2021 The Japanese Society of Veterinary Science.",

year = "2021",

doi = "10.1292/jvms.20-0380",

language = "英語",

volume = "83",

pages = "28--30",

journal = "Journal of Veterinary Medical Science",

issn = "0916-7250",

publisher = "Japanese Society of Veterinary Science",

number = "1",

}

TY - JOUR

T1 - Antifungal drugs-low-susceptibility in aspergillus flavus isolated from a captively reared okinawa rail (Hypotaenidia okinawae)

AU - Kano, Rui

AU - Tsunoi, Meika

AU - Nakaya, Yumiko

AU - Nagamine, Takashi

AU - Ono, Koji

PY - 2021

Y1 - 2021

N2 - A four-month old female Okinawa rail (Hypotaenidia okinawae) presented with respiratory distress. Despite antifungal treatment with voriconazole (VRZ), micafungin (MCF), and itraconazole (ITZ), respiratory distress did not improve and the bird died 167 days after initiating treatment. Necropsy revealed multifocal pyogranulomatous necrotic nodular lesions with numerous whitish-green fungal hyphae in the left air sac. Aspergillus flavus was isolated from the left air sac lesion. Antifungal susceptibility tests indicated that the isolate showed low susceptibility to amphotericin B (AMB), fluconazole (FLZ), VRZ and MCF.

AB - A four-month old female Okinawa rail (Hypotaenidia okinawae) presented with respiratory distress. Despite antifungal treatment with voriconazole (VRZ), micafungin (MCF), and itraconazole (ITZ), respiratory distress did not improve and the bird died 167 days after initiating treatment. Necropsy revealed multifocal pyogranulomatous necrotic nodular lesions with numerous whitish-green fungal hyphae in the left air sac. Aspergillus flavus was isolated from the left air sac lesion. Antifungal susceptibility tests indicated that the isolate showed low susceptibility to amphotericin B (AMB), fluconazole (FLZ), VRZ and MCF.

KW - Antifungal susceptibility tests

KW - Aspergillus flavus

KW - Avian aspergillosis

KW - Low-susceptibility

KW - Okinawa rail

UR - https://www.scopus.com/pages/publications/85100070246

U2 - 10.1292/jvms.20-0380

DO - 10.1292/jvms.20-0380

M3 - コメント/討論

C2 - 33191334

AN - SCOPUS:85100070246

SN - 0916-7250

VL - 83

SP - 28

EP - 30

JO - Journal of Veterinary Medical Science

JF - Journal of Veterinary Medical Science

IS - 1

ER -

Antifungal drugs-low-susceptibility in aspergillus flavus isolated from a captively reared okinawa rail (Hypotaenidia okinawae)

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Keywords

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