Adult rats exposed to low-doses of di-n-butyl phthalate during gestation exhibit decreased grooming behavior

Hideo Hoshi; Teruya Ohtsuka

doi:10.1007/s00128-009-9729-1

Adult rats exposed to low-doses of di-n-butyl phthalate during gestation exhibit decreased grooming behavior

Hideo Hoshi, Teruya Ohtsuka

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Developmental neurotoxicity of low-dose di-n-butyl phthalate (DBP) to rats was studied. Pregnant rats were orally given DBP at doses less than 1.0 mg/kg/day during gestation period. The body weight of all dams and their offspring as well as the offspring's motor function showed no significant adverse effect. At 21 weeks, behaviors of male rats were examined by placing into a test cage. The rats born from dams exposed to 10 μg DBP/kg/day exhibited a significant decrease of grooming. This indicates low-dose DBP adversely affects emotional stability in a novel environment.

Original language	English
Pages (from-to)	62-66
Number of pages	5
Journal	Bulletin of Environmental Contamination and Toxicology
Volume	83
Issue number	1
DOIs	https://doi.org/10.1007/s00128-009-9729-1
State	Published - Jul 2009
Externally published	Yes

Keywords

DBP
Grooming
Low-dose effect
Rat

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10.1007/s00128-009-9729-1

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abstract = "Developmental neurotoxicity of low-dose di-n-butyl phthalate (DBP) to rats was studied. Pregnant rats were orally given DBP at doses less than 1.0 mg/kg/day during gestation period. The body weight of all dams and their offspring as well as the offspring's motor function showed no significant adverse effect. At 21 weeks, behaviors of male rats were examined by placing into a test cage. The rats born from dams exposed to 10 μg DBP/kg/day exhibited a significant decrease of grooming. This indicates low-dose DBP adversely affects emotional stability in a novel environment.",

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author = "Hideo Hoshi and Teruya Ohtsuka",

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N2 - Developmental neurotoxicity of low-dose di-n-butyl phthalate (DBP) to rats was studied. Pregnant rats were orally given DBP at doses less than 1.0 mg/kg/day during gestation period. The body weight of all dams and their offspring as well as the offspring's motor function showed no significant adverse effect. At 21 weeks, behaviors of male rats were examined by placing into a test cage. The rats born from dams exposed to 10 μg DBP/kg/day exhibited a significant decrease of grooming. This indicates low-dose DBP adversely affects emotional stability in a novel environment.

AB - Developmental neurotoxicity of low-dose di-n-butyl phthalate (DBP) to rats was studied. Pregnant rats were orally given DBP at doses less than 1.0 mg/kg/day during gestation period. The body weight of all dams and their offspring as well as the offspring's motor function showed no significant adverse effect. At 21 weeks, behaviors of male rats were examined by placing into a test cage. The rats born from dams exposed to 10 μg DBP/kg/day exhibited a significant decrease of grooming. This indicates low-dose DBP adversely affects emotional stability in a novel environment.

KW - DBP

KW - Grooming

KW - Low-dose effect

KW - Rat

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JO - Bulletin of Environmental Contamination and Toxicology

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ER -

Adult rats exposed to low-doses of di-n-butyl phthalate during gestation exhibit decreased grooming behavior

Abstract

Keywords

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