TY - JOUR
T1 - Adaptive Optics Fundus Camera to Examine Localized Changes in the Photoreceptor Layer of the Fovea
AU - Kitaguchi, Yoshiyuki
AU - Fujikado, Takashi
AU - Bessho, Kenichiro
AU - Sakaguchi, Hirokazu
AU - Gomi, Fumi
AU - Yamaguchi, Tatsuo
AU - Nakazawa, Naoki
AU - Mihashi, Toshifumi
AU - Tano, Yasuo
PY - 2008/10
Y1 - 2008/10
N2 - Purpose: To examine highly localized photoreceptor disruptions in the fovea by a high-resolution adaptive optics (AO) fundus camera combined with Fourier-domain optical coherence tomography (FD OCT). Design: Observational case series. Participants: Three eyes of 3 patients who showed dark foveal spots by slit-lamp biomicroscopy. Methods: Three patients who reported metamorphopsia but showed no changes in the retina in conventional fundus photographs were examined. High-resolution retinal images were obtained with the AO fundus camera and by FD OCT. The images were compared with the findings obtained by standard clinical tests, including Amsler charts and fluorescein angiography (FA). Main Outcome Measures: Quantitative measurements of the area of photoreceptor disruption. Results: Slit-lamp biomicroscopy revealed an irregularly shaped dark spot in the fovea centralis but no changes in FA in the 3 cases. The photoreceptor mosaic was absent in a highly localized area of the fovea in the images obtained by the AO fundus camera, and the photoreceptor outer segment was absent or disturbed at the corresponding area by FD OCT in all 3 cases. The horizontal and vertical sizes of the area of disturbance of the photoreceptor mosaic in the AO images in the 3 eyes were 400×200 μm, 300×120 μm, and 300×200 μm. These sizes were comparable to the photoreceptor outer segment disturbances in the OCT images which were 330×150 μm, 280×100 μm, 200×150 μm, respectively. Conclusions: Localized OS disturbances were able to be detected in eyes with a dark foveal spot by AO fundus camera 2-dimensionally and by FD OCT axially. The good correspondence of the sizes of the area of photoreceptor disturbances obtained by AO images to those by FD OCT images indicate that the AO images can be used to evaluate and follow the 2-dimensional area of focal changes of the photoreceptors in the fovea quantitatively. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references.
AB - Purpose: To examine highly localized photoreceptor disruptions in the fovea by a high-resolution adaptive optics (AO) fundus camera combined with Fourier-domain optical coherence tomography (FD OCT). Design: Observational case series. Participants: Three eyes of 3 patients who showed dark foveal spots by slit-lamp biomicroscopy. Methods: Three patients who reported metamorphopsia but showed no changes in the retina in conventional fundus photographs were examined. High-resolution retinal images were obtained with the AO fundus camera and by FD OCT. The images were compared with the findings obtained by standard clinical tests, including Amsler charts and fluorescein angiography (FA). Main Outcome Measures: Quantitative measurements of the area of photoreceptor disruption. Results: Slit-lamp biomicroscopy revealed an irregularly shaped dark spot in the fovea centralis but no changes in FA in the 3 cases. The photoreceptor mosaic was absent in a highly localized area of the fovea in the images obtained by the AO fundus camera, and the photoreceptor outer segment was absent or disturbed at the corresponding area by FD OCT in all 3 cases. The horizontal and vertical sizes of the area of disturbance of the photoreceptor mosaic in the AO images in the 3 eyes were 400×200 μm, 300×120 μm, and 300×200 μm. These sizes were comparable to the photoreceptor outer segment disturbances in the OCT images which were 330×150 μm, 280×100 μm, 200×150 μm, respectively. Conclusions: Localized OS disturbances were able to be detected in eyes with a dark foveal spot by AO fundus camera 2-dimensionally and by FD OCT axially. The good correspondence of the sizes of the area of photoreceptor disturbances obtained by AO images to those by FD OCT images indicate that the AO images can be used to evaluate and follow the 2-dimensional area of focal changes of the photoreceptors in the fovea quantitatively. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references.
UR - https://www.scopus.com/pages/publications/52949131358
U2 - 10.1016/j.ophtha.2008.03.026
DO - 10.1016/j.ophtha.2008.03.026
M3 - 記事
C2 - 18486223
AN - SCOPUS:52949131358
SN - 0161-6420
VL - 115
SP - 1771
EP - 1777
JO - Ophthalmology
JF - Ophthalmology
IS - 10
ER -