A Single Intraperitoneal Injection of Endotoxin Changes Glial Cells in Rats as Revealed by Positron Emission Tomography Using [11C]PK11195

Miho Ota; Jun Ogura; Shintaro Ogawa; Koichi Kato; Hiroshi Matsuda; Hiroshi Kunugi

doi:10.1007/s13139-017-0510-9

A Single Intraperitoneal Injection of Endotoxin Changes Glial Cells in Rats as Revealed by Positron Emission Tomography Using [¹¹C]PK11195

Miho Ota
, Jun Ogura
, Shintaro Ogawa
, Koichi Kato
, Hiroshi Matsuda
, Hiroshi Kunugi

National Center of Neurology and Psychiatry Kodaira
National Center Hospital of Neurology and Psychiatry

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Purpose: Intracranial administration of lipopolysaccharide (LPS) is known to elicit a rapid innate immune response, activate glial cells in the brain, and induce depression-like behavior. However, no study has focused on the changes in glial cells induced by intraperitoneal injection of LPS in vivo. Methods: Ten adult male Fischer F344 rats underwent [¹¹C]PK11195 PET before and 2 days after intraperitoneal injection of LPS to evaluate the changes in glial cells. The difference in standardized uptake values (SUV) of [¹¹C]PK11195 between before and after injection was determined. Results: There was a cluster of brain regions that showed significant reductions in SUV. This cluster included the bilateral striata and bilateral frontal regions, especially the somatosensory areas. Conclusions: Changes in activity of glial cells induced by the intraperitoneal injection of LPS were detected in vivo by [¹¹C]PK11195 PET. Intraperitoneal injection of LPS is known to induce depression, and further studies with [¹¹C]PK11195 PET would clarify the relationships between neuroinflammation and depression.

Original language	English
Pages (from-to)	224-228
Number of pages	5
Journal	Nuclear Medicine and Molecular Imaging
Volume	52
Issue number	3
DOIs	https://doi.org/10.1007/s13139-017-0510-9
State	Published - 1 Jun 2018
Externally published	Yes

Keywords

Glial cells
Lipopolysaccharides
Positron emission tomography
Somatosensory area
[C]PK11195

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10.1007/s13139-017-0510-9

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title = "A Single Intraperitoneal Injection of Endotoxin Changes Glial Cells in Rats as Revealed by Positron Emission Tomography Using [11C]PK11195",

abstract = "Purpose: Intracranial administration of lipopolysaccharide (LPS) is known to elicit a rapid innate immune response, activate glial cells in the brain, and induce depression-like behavior. However, no study has focused on the changes in glial cells induced by intraperitoneal injection of LPS in vivo. Methods: Ten adult male Fischer F344 rats underwent [11C]PK11195 PET before and 2 days after intraperitoneal injection of LPS to evaluate the changes in glial cells. The difference in standardized uptake values (SUV) of [11C]PK11195 between before and after injection was determined. Results: There was a cluster of brain regions that showed significant reductions in SUV. This cluster included the bilateral striata and bilateral frontal regions, especially the somatosensory areas. Conclusions: Changes in activity of glial cells induced by the intraperitoneal injection of LPS were detected in vivo by [11C]PK11195 PET. Intraperitoneal injection of LPS is known to induce depression, and further studies with [11C]PK11195 PET would clarify the relationships between neuroinflammation and depression.",

keywords = "Glial cells, Lipopolysaccharides, Positron emission tomography, Somatosensory area, [C]PK11195",

author = "Miho Ota and Jun Ogura and Shintaro Ogawa and Koichi Kato and Hiroshi Matsuda and Hiroshi Kunugi",

note = "Publisher Copyright: {\textcopyright} 2018, Korean Society of Nuclear Medicine.",

year = "2018",

month = jun,

day = "1",

doi = "10.1007/s13139-017-0510-9",

language = "英語",

volume = "52",

pages = "224--228",

journal = "Nuclear Medicine and Molecular Imaging",

issn = "1869-3474",

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number = "3",

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TY - JOUR

T1 - A Single Intraperitoneal Injection of Endotoxin Changes Glial Cells in Rats as Revealed by Positron Emission Tomography Using [11C]PK11195

AU - Ota, Miho

AU - Ogura, Jun

AU - Ogawa, Shintaro

AU - Kato, Koichi

AU - Matsuda, Hiroshi

AU - Kunugi, Hiroshi

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Purpose: Intracranial administration of lipopolysaccharide (LPS) is known to elicit a rapid innate immune response, activate glial cells in the brain, and induce depression-like behavior. However, no study has focused on the changes in glial cells induced by intraperitoneal injection of LPS in vivo. Methods: Ten adult male Fischer F344 rats underwent [11C]PK11195 PET before and 2 days after intraperitoneal injection of LPS to evaluate the changes in glial cells. The difference in standardized uptake values (SUV) of [11C]PK11195 between before and after injection was determined. Results: There was a cluster of brain regions that showed significant reductions in SUV. This cluster included the bilateral striata and bilateral frontal regions, especially the somatosensory areas. Conclusions: Changes in activity of glial cells induced by the intraperitoneal injection of LPS were detected in vivo by [11C]PK11195 PET. Intraperitoneal injection of LPS is known to induce depression, and further studies with [11C]PK11195 PET would clarify the relationships between neuroinflammation and depression.

AB - Purpose: Intracranial administration of lipopolysaccharide (LPS) is known to elicit a rapid innate immune response, activate glial cells in the brain, and induce depression-like behavior. However, no study has focused on the changes in glial cells induced by intraperitoneal injection of LPS in vivo. Methods: Ten adult male Fischer F344 rats underwent [11C]PK11195 PET before and 2 days after intraperitoneal injection of LPS to evaluate the changes in glial cells. The difference in standardized uptake values (SUV) of [11C]PK11195 between before and after injection was determined. Results: There was a cluster of brain regions that showed significant reductions in SUV. This cluster included the bilateral striata and bilateral frontal regions, especially the somatosensory areas. Conclusions: Changes in activity of glial cells induced by the intraperitoneal injection of LPS were detected in vivo by [11C]PK11195 PET. Intraperitoneal injection of LPS is known to induce depression, and further studies with [11C]PK11195 PET would clarify the relationships between neuroinflammation and depression.

KW - Glial cells

KW - Lipopolysaccharides

KW - Positron emission tomography

KW - Somatosensory area

KW - [C]PK11195

UR - https://www.scopus.com/pages/publications/85048488022

U2 - 10.1007/s13139-017-0510-9

DO - 10.1007/s13139-017-0510-9

M3 - 記事

AN - SCOPUS:85048488022

SN - 1869-3474

VL - 52

SP - 224

EP - 228

JO - Nuclear Medicine and Molecular Imaging

JF - Nuclear Medicine and Molecular Imaging

IS - 3

ER -

A Single Intraperitoneal Injection of Endotoxin Changes Glial Cells in Rats as Revealed by Positron Emission Tomography Using [¹¹C]PK11195

Abstract

Keywords

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